Review of fungal skin infections and their invasion

Hilles, Ayah Rebhi; Mahmood, Syed; Kaderi, Mohd Arifin; Hashim, Rosnani

doi:10.36547/ft.2019.2.2.3-5

Cited by 4 publications

(1 citation statement)

References 12 publications

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“…The numerous fungi that colonise the surface of the skin, including those generally innocuous (e.g., genera Malassezia ) and those that are pathogenic (e.g., dermatophytes, genera Candida ), are characterised by phylogenetic divergence [ 10 , 11 , 16 , 17 , 18 ]. Despite their differences, they all have a structurally complex hallmark feature known as the cell wall, which is primarily made of a variety of polysaccharides (e.g., glucans, chitin) and (glyco)proteins (e.g., NO-linked oligosaccharides) [ 19 ].…”

Section: Introduction: the Human Skin And Fungal Infectionsmentioning

confidence: 99%

Emerging Trends in the Use of Topical Antifungal-Corticosteroid Combinations

Mijaljica¹,

Spada²,

Harrison³

2022

JoF

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A broad range of topical antifungal formulations containing miconazole or terbinafine as actives are commonly used as efficacious choices for combating fungal skin infections. Their many benefits, owing to their specific mechanism of action, include their ability to target the site of infection, enhance treatment efficacy and reduce the risk of systemic side effects. Their proven efficacy, and positioning in the treatment of fungal skin infections, is enhanced by high patient compliance, especially when appropriate vehicles such as creams, ointments and gels are used. However, inflammation as a result of fungal infection can often impede treatment, especially when combined with pruritus (itch), an unpleasant sensation that elicits an urge to scratch. The scratching that occurs in response to pruritus frequently accelerates skin damage, ultimately aggravating and spreading the fungal infection. To help overcome this issue, a topical antifungal-corticosteroid combination consisting of miconazole or terbinafine and corticosteroids of varying potencies should be used. Due to their inherent benefits, these topical antifungal-corticosteroid combinations can concomitantly and competently attenuate inflammation, relieve pruritus and treat fungal infection.

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Section: Introduction: the Human Skin And Fungal Infectionsmentioning

confidence: 99%

Emerging Trends in the Use of Topical Antifungal-Corticosteroid Combinations

Mijaljica¹,

Spada²,

Harrison³

2022

JoF

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Advances in Antimicrobial Microneedle Patches for Combating Infections

et al. 2020

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Skin infections caused by bacteria, viruses and fungi are difficult to treat by conventional topical administration because of poor drug penetration across the stratum corneum. This results in low bioavailability of drugs to the infection site, as well as the lack of prolonged release. Emerging antimicrobial transdermal and ocular microneedle patches have become promising medical devices for the delivery of various antibacterial, antifungal, and antiviral therapeutics. In the present review, skin anatomy and its barriers along with skin infection are discussed. Potential strategies for designing antimicrobial microneedles and their targeted therapy are outlined. Finally, biosensing microneedle patches associated with personalized drug therapy and selective toxicity toward specific microbial species are discussed.

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