Review of low-cost self-driving laboratories in chemistry and materials science: the “frugal twin” concept

Lo, Stanley; Baird, Sterling G.; Schrier, Joshua; Blaiszik, Ben; Carson, Nessa; Foster, Ian; Aguilar-Granda, Andrés; Kalinin, Sergei V.; Maruyama, Benji; Politi, Maria; Tran, Helen; Sparks, Taylor D.; Aspuru-Guzik, Alán

doi:10.1039/d3dd00223c

Cited by 8 publications

(2 citation statements)

References 141 publications

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“…Open source hardware and more accessible frugal twins aim to similarly “democratize” physical experiments. 24 We note that while open source is the gold standard and should remain a priority to the community—especially for academic and prototyping research—we expect that well-documented and well-supported proprietary tools will become a practical alternative in many labs.…”

Section: Discussionmentioning

confidence: 99%

Autonomous laboratories for accelerated materials discovery: a community survey and practical insights

Hung,

Yager,

Monteverde

et al. 2024

Digital Discovery

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Section: Discussionmentioning

confidence: 99%

Autonomous laboratories for accelerated materials discovery: a community survey and practical insights

Hung,

Yager,

Monteverde

et al. 2024

Digital Discovery

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“…39 Moreover, open hardware for lab automation has been proposed to lower the financial barrier to building a SDL. 40 In this subsection, we will review the various automated hardware modules, and provide a brief discussion on the development of general-purpose chemistry robotics platforms. (Figure 2) A summary of the distinctions between the hardware types are shown in Table 1.…”

Section: Hardwarementioning

confidence: 99%

Self-Driving Laboratories for Chemistry and Materials Science

Tom,

Schmid,

Baird

et al. 2024

Preprint

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Self-driving laboratories (SDLs) promise an accelerated application of the scientific method. Through the automation of experimental workflows, along with the autonomization of experiment planning, SDLs hold the potential to greatly accelerate research in chemistry and materials discovery. This review article provides an in-depth analysis of the state-of-the-art in SDL technology, its applications across various scientific disciplines, and the potential implications for research, and industry. This review additionally provides an overview of the enabling technologies for SDLs, including their hardware, software, and integration with laboratory infrastructure. Most importantly, this review explores the diverse range of scientific domains where SDLs have made significant contributions, from drug discovery and materials science to genomics and chemistry. We provide a comprehensive review of existing real-world examples of SDLs, their different levels of automation, and the challenges and limitations associated with each domain.

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Self-Driving Laboratories for Chemistry and Materials Science

Tom,

Schmid,

Baird

et al. 2024

Chem. Rev.

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Self-driving laboratories (SDLs) promise an accelerated application of the scientific method. Through the automation of experimental workflows, along with autonomous experimental planning, SDLs hold the potential to greatly accelerate research in chemistry and materials discovery. This review provides an in-depth analysis of the state-of-the-art in SDL technology, its applications across various scientific disciplines, and the potential implications for research and industry. This review additionally provides an overview of the enabling technologies for SDLs, including their hardware, software, and integration with laboratory infrastructure. Most importantly, this review explores the diverse range of scientific domains where SDLs have made significant contributions, from drug discovery and materials science to genomics and chemistry. We provide a comprehensive review of existing real-world examples of SDLs, their different levels of automation, and the challenges and limitations associated with each domain.

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Review of low-cost self-driving laboratories in chemistry and materials science: the “frugal twin” concept

Abstract: This review proposes the concept of a “frugal twin,” similar to a digital twin, but for physical experiments. Frugal twins range from simple toy examples to low-cost surrogates of high-cost...

Cited by 8 publications

References 141 publications

Autonomous laboratories for accelerated materials discovery: a community survey and practical insights

Autonomous laboratories for accelerated materials discovery: a community survey and practical insights

Self-Driving Laboratories for Chemistry and Materials Science

Self-Driving Laboratories for Chemistry and Materials Science

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