Review of meningioma histopathology

Commins, Deborah; Atkinson, Roscoe; Burnett, Margaret

doi:10.3171/foc-07/10/e3

Cited by 145 publications

(87 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The specific changes in the criteria have been described in detail elsewhere. 4 Briefly, classification criteria were vague prior to 2000; for example, 1 criterion for atypical disease was the presence of "frequent mitoses," although what con- 2 Unfortunately, our study was insufficiently powered to compare overall survival and progression-free survival between Grade I tumors based on WHO classification scheme. While it appears that Grade II tumors were more common in our series with the 2000 and 2007 schemes, there is likely a selection bias as patients treated prior to 2000 were much less likely to undergo SRS, especially if they had known atypical or malignant disease.…”

Section: Role Of Histology In Disease Progressionmentioning

confidence: 99%

Patterns of recurrence after stereotactic radiosurgery for treatment of meningiomas

Kuhn¹,

Taksler

Dayton

et al. 2013

FOC

View full text Add to dashboard Cite

Object The purpose of this study was to evaluate patterns of failure after stereotactic radiosurgery (SRS) for meningiomas and factors that may influence these outcomes. Methods Based on a retrospective chart review, 279 patients were treated with SRS for meningiomas between January 1999 and March 2011 at Wake Forest Baptist Health. Disease progression was determined using serial imaging, with a minimum follow-up of 6 months (median 34.2 months). Results The median margin dose was 12.0 Gy (range 8.8–20 Gy). Local control rates for WHO Grade I tumors were 96.6%, 84.4%, and 75.7% at 1, 3, and 5 years, respectively. WHO Grade II and III tumors had local control rates of 72.3%, 57.7%, and 52.9% at 1, 3, and 5 years, respectively. Tumors without pathological grading had local control rates of 98.7%, 97.6%, and 94.2% at 1, 3, and 5 years, respectively. Of the local recurrences, 63.1% were classified as marginal (within 2 cm of treatment field). The 1-, 3-, and 5-year rates of distant failure were 6.5%, 10.3%, and 16.6%, respectively, for Grade I tumors and 11.4%, 17.2%, and 22.4%, respectively, for Grade II/III tumors. Tumors without pathological grading had distant failure rates of 0.7%, 3.2%, and 6.5% at 1, 3, and 5 years, respectively. Wilcoxon analysis revealed that multifocal disease (p < 0.001) and high-grade histology (WHO Grade II or III; p < 0.001) were significant predictors of local recurrence. Additionally, male sex was a significant predictor of distant recurrence (p = 0.04). Multivariate analysis also showed that doses greater than or equal to 12 Gy were associated with improved local control (p = 0.015). Conclusions In this patient series, 12 Gy was the minimum sufficient margin dose for the treatment of meningiomas. Male sex is a risk factor for distant failure, whereas high-grade histology and multifocal disease are risk factors for local failure.

show abstract

Section: Role Of Histology In Disease Progressionmentioning

confidence: 99%

Patterns of recurrence after stereotactic radiosurgery for treatment of meningiomas

Kuhn¹,

Taksler

Dayton

et al. 2013

FOC

View full text Add to dashboard Cite

show abstract

“…Some studies show a significant correlation between high mitotic index and negative progesterone receptor or positive strogen receptor status, but the efficacy of antiprogesterone agents and the progesterone receptor status of meningiomas remains inadequately explained. 3,7) In this review, almost all meningiomas were World Health Organization grade I meningoendothelial, psammomatous, and transitional types. However, no correlation between high grade meningioma and male sex could be demonstrated by the present data.…”

Section: Demographic Datamentioning

confidence: 99%

“…Higher grade meningiomas do not receive gross total removal and still show high recurrence and mortality levels. 3,15) Surgical morbidity and mortality are usually associated with the damage to the LCNs, FN, or brain stem. Successful surgery consists of preservation of the LCN functions, hearing, and FN status, as well as gross total tumor extirpation.…”

Section: Surgical Outcomementioning

confidence: 99%

Jugular Foramen Meningiomas: Review of the Major Surgical Series

Bakar

2010

Neurol. Med. Chir.(Tokyo)

View full text Add to dashboard Cite

Primary jugular foramen meningiomas are uncommon, with 96 previous cases published between 1992 and 2007. Exact location and extent of tumor were determined on the basis of radiologic and operative findings and used to develop a staging system. The mean age of patients was 39.4 years. The lesion was located on the right in 14 patients and on the left in 11 patients. The series identified 23 males and 58 females. The most common presenting clinical symptoms were hearing loss and tinnitus. Most clinical findings were middle ear mass and neck mass. Most meningiomas were World Health Organization grade I. The most common postoperative complications were lower cranial nerve paresis and facial nerve paresis. Surgical planning should consider that meningiomas usually invade the dura mater, cranial nerves, and surrounding bone. The surgeon should carefully collect detailed data about the tumor, and consult an otolaryngologist preoperatively for lower cranial nerve functions and hearing levels.

show abstract

“…11 The extent of resection and WHO histopathological grade are the most important factors in determining clinical outcome. 6,29 Identifying meningiomas with advanced histopathological grade using preoperative MRI is important. This maneuver could achieve more appropriate tumor resection and even underlying dura substitution in treating advanced meningiomas.…”

mentioning

confidence: 99%

Correlation between magnetic resonance imaging grading and pathological grading in meningioma

Lin

Chou

Kao³

et al. 2014

JNS

100

View full text Add to dashboard Cite

Object This study investigated the specific preoperative MRI features of patients with intracranial meningiomas that correlate with pathological grade and provide appropriate preoperative planning. Methods From 2006 to 2012, 120 patients (36 men and 84 women, age range 20–89 years) with newly diagnosed symptomatic intracranial meningiomas undergoing resection were retrospectively analyzed in terms of radiological features of preoperative MRI. There were 90 WHO Grade I and 30 WHO Grade II or III meningiomas. The relationships between MRI features and WHO histopathological grade were analyzed and scored quantitatively. Results According to the results of multivariate logistic regression analysis, age ≥ 75 years, indistinct tumorbrain interface, positive capsular enhancement, and heterogeneous tumor enhancement were identified factors in the prediction of advanced histopathological grade. The prediction model was quantified as a scoring scale: 2 × (age) + 5 × (tumor-brain interface) + 3 × (capsular enhancement) + 2 × (tumor enhancement). The calculated score correlated positively with the probability of high-grade meningioma. Conclusions This scoring approach may be useful for clinicians in determining therapeutic strategy and in surgical planning for patients with intracranial meningiomas.

show abstract

Review of meningioma histopathology

Cited by 145 publications

References 46 publications

Patterns of recurrence after stereotactic radiosurgery for treatment of meningiomas

Patterns of recurrence after stereotactic radiosurgery for treatment of meningiomas

Jugular Foramen Meningiomas: Review of the Major Surgical Series

Correlation between magnetic resonance imaging grading and pathological grading in meningioma

Contact Info

Product

Resources

About