Background: Non-communicable diseases (NCDs) are the leading causes of death worldwide. In the UAE, NCDs account for nearly 77% of all deaths. There is limited empirical research on this topic in the UAE. We aim to examine this association among the adult population in the Emirate of Dubai.Method: This study used data from the Dubai Household Health Survey (DHHS), 2019. In this survey, 2,247 families were interviewed and only adults aged 18+ were included for the analysis. The self-reported chronic disease was defined as reporting any chronic morbidities occurred during the past year that required ongoing medical attention and medical care. Sociodemographic characteristics covariates were age group, marital status, nationality, gender, education and working status. The quasi-binomial distribution was used to identify factors associated with chronic disease.Results: The prevalence of chronic diseases among the adult population of Dubai was 15.01%. Individuals aged 60+, local Arabs (Emirati), divorced and widowed individuals, and individuals who were not currently working reported a chronic disease more than the other groups. In the regression analysis, age (years) was the strongest predictor (OR 3.6, 95% CI: 2.8, 4.7). Males were more likely to report a chronic disease (OR 1.61, 95% CI: 1.277, 2.035). Unmarried individuals were less likely to report a chronic disease (OR 0.11, 95% CI: 0.02, 0.70). However, older individuals who were unmarried were more likely to report a chronic disease compared to the reference group (OR 2.8, 95% CI: 1.2, 6.1). Emiratis were more likely to report a chronic disease (OR 2.08, 95% CI: 1.62, 2.67).Conclusion: The self-reported rate of chronic disease was shown to be higher in older individuals, males, Emiratis, and older individuals who were unmarried. This is one of the few studies related to chronic diseases in Dubai. It is important to translate the current study findings into policies to help reduce the incidence of chronic diseases in Dubai and to minimize the negative impact of these illnesses, particularly among those with the sociodemographic risk factors identified here. In addition, healthcare services and resources should be reallocated to the population groups with greater health needs.