Review of Noninvasive Continuous Glucose Monitoring in Diabetics

Li, Yilin; Chen, Yueyue

doi:10.1021/acssensors.3c01538

Cited by 21 publications

(3 citation statements)

References 144 publications

(324 reference statements)

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“…Glucose concentrations in sweat typically lag changes in the blood, resulting in lower postexercise correlation multiples than in the other two states (Figure S7). 60 These results indicate that the biosensor has a potential application prospect in the detection of glucose in human sweat.…”

Section: ■ Introductionmentioning

confidence: 86%

Carboxymethyl Cellulose Sodium Nanocomposite Hydrogels for Flexible Sensors of Human Motion and Glucose Levels in Sweat

Zhou,

Liu,

Liu

et al. 2024

ACS Appl. Polym. Mater.

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In recent years, there has been an increasing interest in the use of biomass-based nanocomposite hydrogels for wearable flexible sweat sensors. In this manuscript, the design of a dual-network hydrogel using sodium carboxymethyl cellulose (CMC-Na) to develop a high-performance nanocomposite hydrogel flexible sensor is considered to be an effective method for accurate monitoring of human movement and continuous noninvasive measurement of glucose levels in sweat. The gel has a measurement gauge factor (GF) of 1.34 and a toughness of 4.18 MJ/m 3 , exhibiting excellent mechanical properties and self-healing capabilities (92.6%). As a flexible motion sensor, it can accurately identify various human movements. By incorporating glucose oxidase-thioglycolic acid-gold nanoparticles (GTAN) nanomaterials into the hydrogel, stable and excellent electrocatalytic activity for sweat glucose measurement was achieved. The sensor has a detection limit (LOD) of 0.28 μM and a wide operating range. Additionally, different testing methods show good linear relationships, indicating the sensor's universality in measurement. By analyzing daily physical activities and levels of glucose in sweat, monitoring of individual health can be achieved, thereby expanding the potential of next-generation noninvasive multifunctional sensing systems.

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Section: ■ Introductionmentioning

confidence: 86%

Carboxymethyl Cellulose Sodium Nanocomposite Hydrogels for Flexible Sensors of Human Motion and Glucose Levels in Sweat

Zhou,

Liu,

Liu

et al. 2024

ACS Appl. Polym. Mater.

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show abstract

“…In addition to the above detection indicators, real-time detection of changes in individual indicators such as ROS and glucose is also important for the timely adjustment of treatment planning to lower unnecessary side effects and improve treatment outcomes. 107,108…”

Section: Smart Hydrogels For Wound Monitoringmentioning

confidence: 99%

Recent advances of hydrogels as smart dressings for diabetic wounds

Wang,

Yang,

Zhao

et al. 2024

J. Mater. Chem. B

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“…Therefore, there is a crucial need to accurately and quantitatively monitor glucose levels in human body fluids for effective clinical management. The standard method for glucose monitoring involves analyzing blood samples, for which sample collection is invasive and can be distressing for the patient . In contrast, urine samples offer a more convenient and noninvasive alternative.…”

Section: Introductionmentioning

confidence: 99%

Dual-Probe SERS Nanosensor: A Promising Approach for Sensitive and Ratiometric Detection of Glucose in Clinical Settings

Li,

Zhang,

Sun

et al. 2024

ACS Appl. Bio Mater.

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Diabetes is a major global health concern, with millions of annual deaths. Monitoring glucose levels is vital for clinical management, and urine samples offer a noninvasive alternative to blood samples. Optical techniques for urine glucose sensing have gained notable traction due to their cost-effectiveness and portability. Among these methods, surface-enhanced Raman spectroscopy (SERS) has attracted considerable attention thanks to its remarkable sensitivity and multiplexing capabilities. However, challenges remain in achieving reliable quantification through SERS. In this study, an alternative approach is proposed to enhance quantification involving the use of dual probes. Each probe is encoded with unique SERS signatures strategically positioned in the biologically silent region. One probe indicates the glucose presence, while the other acts as an internal reference for calibration. This setup enables ratiometric analysis of the SERS signal, directly correlating it with the glucose concentration. The fabrication of the sensor relies on the prefunctionalization of Fe sheets using an aryl diazonium salt bearing a –CCH group (internal reference), followed by the immobilization of Ag nanoparticles modified with an aryl diazonium salt bearing a –B(OH)2 group (for glucose capture). A secondary probe bearing a –B(OH)2 group on one side and a –CN group on the other side enables the ratiometric analysis by forming a sandwich-like structure in the presence of glucose (glucose indicator). Validation studies in aqueous solutions and artificial urine demonstrated the high spectral stability and the potential of this dual-probe nanosensor for sensitive glucose monitoring in clinical settings.

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Review of Noninvasive Continuous Glucose Monitoring in Diabetics

Abstract: application. This presents us with a serious challenge. With our joint efforts and ongoing technological advancements, noninvasive CGM systems are demonstrating significant promise and are expected to overtake current blood glucose monitoring practices in the future.

Cited by 21 publications

References 144 publications

Carboxymethyl Cellulose Sodium Nanocomposite Hydrogels for Flexible Sensors of Human Motion and Glucose Levels in Sweat

Carboxymethyl Cellulose Sodium Nanocomposite Hydrogels for Flexible Sensors of Human Motion and Glucose Levels in Sweat

Recent advances of hydrogels as smart dressings for diabetic wounds

Dual-Probe SERS Nanosensor: A Promising Approach for Sensitive and Ratiometric Detection of Glucose in Clinical Settings

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