Review of OCT Angiography Findings in Diabetic Retinopathy: Insights and Perspectives

Moir, John; Khanna, Saira; Skondra, Dimitra

doi:10.3390/ijtm1030017

Cited by 12 publications

(6 citation statements)

References 172 publications

(239 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moir et al [ 29 ] stated that quantitative angiography indices including FAZ and VD parameters, fractal dimension (FD), vessel tortuosity (VT), and areas of flow deficits or non-perfusion within the CC are possible biomarkers for the detection and progression of both DM and DR. However, these have been inconsistently used in the literature, on account of limitations in software packages incorporated in equipment.…”

Section: Discussionmentioning

confidence: 99%

The Association of Neovascularization With Optical Coherence Tomography Angiography Parameters in Proliferative Diabetic Retinopathy

Sodhi¹,

Shaw²,

Gautam³

et al. 2023

Cureus

View full text Add to dashboard Cite

Aim: We aim to find an association between neovascularization (NVn) and optical coherence tomography angiography (OCTA) parameters in proliferative diabetic retinopathy (PDR).Methods: In a prospective study, 41 subjects including 28 (68%) males and 13 (32%) females having PDR were examined for neovascularization disc (NVD) and neovascularization elsewhere (NVE) clinically and with fundus fluorescein angiography (FFA). A total of 79 eyes were found to be involved. We examined OCTA parameters including foveal avascular zone (FAZ) size, perimeter and circularity, and vessel density (VD) in the superficial capillary plexus (SCP), deep capillary plexus (DCP), outer retina (OR), outer retinal choriocapillaries (ORCC), chorio-capillaries (CC), and choroid (C) in these subjects.Results: In eyes with NVD, the central foveal thickness (CFT) (p=0.83) and sub-foveal choroidal thickness (SFCT) (p=0.08) were higher, the FAZ area was significantly larger (p=0.005), and the VD was lower in all retino-choroidal layers. However, it was significantly lower in SCP foveal (p=0.005) and ORCC foveal (p=0.05) than in eyes not having NVD. For NVE, the CFT (p=0.03) and SFCT (p=0.01) were more in affected eyes. The eyes without NVE had a better circularity index (p=0.07) and the highest VD in OR slab (p=0.02) than those eyes that had NVE < ½ disc area (DA) and NVE > ½ DA. On comparing eyes without NVE, NVE < ½ DA, and NVE > ½ DA, the latest had the highest VD in SCP (p=0.59) and lowest VD in DCP (p=0.43) and OR (p=0.02). The VD in ORCC, CC, and choroid was highest in the no NVE group, followed by the NVE > ½ DA and NVE < ½ DA groups in that order. The subjects having vitreous hemorrhage (VH) and intra-retinal microvascular abnormalities (IRMA) had higher values for CFT and SFCT than eyes without these.Conclusions: An increased CFT and SFCT are associated with the appearance of NVD, NVE, VH, and IRMA. The presence of NVD, VH, and IRMA is associated with a larger FAZ area, while that of IRMA and NVE is associated with reduced FAZ circularity. Eyes with NVD, VH, and IRMA had lesser VD in all the retinochoroidal layers. Eyes with NVE > ½ DA had the highest VD in SCP and lowest in DCP and OR; this pattern of VD foretells severer affection in NVE. IRMA was associated with a larger FAZ area, larger FAZ perimeter, and lesser circularity, indicating the presence of central ischemia.

show abstract

Section: Discussionmentioning

confidence: 99%

The Association of Neovascularization With Optical Coherence Tomography Angiography Parameters in Proliferative Diabetic Retinopathy

Sodhi¹,

Shaw²,

Gautam³

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

“…With the assistance of OCT-A, it becomes possible to accurately identify the capillary networks within the retinal or choroidal plexus where diabetic changes may occur (Moir et al, 2021). Three vascular networks are located in the structure of the human retina: the superficial networks in the neurofibrillary and ganglion layers, the intermediate networks in the inner plexiform and nuclear layers, and the deep networks in the inner nuclear and outer plexiform layers (Balaratnasingam et al, 2018;Chan et al, 2012).…”

Section: Research Articlementioning

confidence: 99%

Vascular and perfusion density in superficial capillary plexus of macula as a biomarker for appearance of diabetic retinopathy

Koseva,

Hristova,

Zlatarova

2023

SEHS

View full text Add to dashboard Cite

Diabetic alteration of the retinal microenvironment causes damage to the retinal vessels. Biomarkers such as vessel density and perfusion density, measured using optical coherence tomography angiography (OCT-A), may help detect early signs of diabetic retinopathy (DR) and track disease progression. In our study, we categorized 212 individuals into 2 groups: Group I (75 healthy individuals) and Group II (137 people with diabetes). All participants underwent comprehensive eye examinations, including OCT-A with AngioPlex™ system. The measurements taken of the superficial retinal capillary plexus included vessel and perfusion density. Our findings showed that vessel and perfusion densities in the central, inner, and outer ETDRS fields, as well as the full macular area, decreased with age. Notably, vessel and perfusion densities in the inner, outer, and full ETDRS macular areas in diabetic patients with mild DR were significantly lower, compared to those in healthy subjects. In conclusion, this study emphasizes the importance of vessel and perfusion densities as biomarkers for early diabetic retinopathy. However, it is important to note that their reduction does not precede clinical signs of diabetic retinopathy.

show abstract

“…The 3D visualization provided by OCTA images is useful for analyzing MAs and their spatial orientation [5]. MAs appear as saccular or fusiform in these images [41]. Some previous studies have compared FA and OCTA imaging and concluded that FA detects a higher number of MAs than OCTA [42][43][44].…”

Section: Fundusmentioning

confidence: 99%

Automatic Detection of Microaneurysms in OCT Images Using Bag of Features

Kazeminasab

Almasi

Shoushtarian

et al. 2022

Computational and Mathematical Methods in Medicine

View full text Add to dashboard Cite

Diabetic retinopathy (DR) caused by diabetes occurs as a result of changes in the retinal vessels and causes visual impairment. Microaneurysms (MAs) are the early clinical signs of DR, whose timely diagnosis can help detecting DR in the early stages of its development. It has been observed that MAs are more common in the inner retinal layers compared to the outer retinal layers in eyes suffering from DR. Optical coherence tomography (OCT) is a noninvasive imaging technique that provides a cross-sectional view of the retina, and it has been used in recent years to diagnose many eye diseases. As a result, this paper attempts to identify areas with MA from normal areas of the retina using OCT images. This work is done using the dataset collected from FA and OCT images of 20 patients with DR. In this regard, firstly fluorescein angiography (FA) and OCT images were registered. Then, the MA and normal areas were separated, and the features of each of these areas were extracted using the Bag of Features (BOF) approach with the Speeded-Up Robust Feature (SURF) descriptor. Finally, the classification process was performed using a multilayer perceptron network. For each of the criteria of accuracy, sensitivity, specificity, and precision, the obtained results were 96.33%, 97.33%, 95.4%, and 95.28%, respectively. Utilizing OCT images to detect MAs automatically is a new idea, and the results obtained as preliminary research in this field are promising.

show abstract

Review of OCT Angiography Findings in Diabetic Retinopathy: Insights and Perspectives

Cited by 12 publications

References 172 publications

The Association of Neovascularization With Optical Coherence Tomography Angiography Parameters in Proliferative Diabetic Retinopathy

The Association of Neovascularization With Optical Coherence Tomography Angiography Parameters in Proliferative Diabetic Retinopathy

Vascular and perfusion density in superficial capillary plexus of macula as a biomarker for appearance of diabetic retinopathy

Automatic Detection of Microaneurysms in OCT Images Using Bag of Features

Contact Info

Product

Resources

About