Review of -omics studies on mosquito-borne viruses of the Flavivirus genus

Peinado, Rafaela dos S.; Eberle, Raphael J.; Pacca, Carolina Colombelli; Arni, R.K.; Coronado, Mônika A.

doi:10.1016/j.virusres.2021.198610

Cited by 8 publications

(3 citation statements)

References 187 publications

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“…The genus Flavivirus encompasses 53 enveloped positive-sense single RNA viruses. The virion consists of the three structural proteins (capsid (C), membrane (M), and envelope (E)) and seven nonstructural proteins presented in infected cells (NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5) [ 1 , 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

The Importance of Epigallocatechin as a Scaffold for Drug Development against Flaviviruses

et al. 2023

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Arboviruses such as Dengue, yellow fever, West Nile, and Zika are flaviviruses vector-borne RNA viruses transmitted biologically among vertebrate hosts by blood-taking vectors. Many flaviviruses are associated with neurological, viscerotropic, and hemorrhagic diseases, posing significant health and socioeconomic concerns as they adapt to new environments. Licensed drugs against them are currently unavailable, so searching for effective antiviral molecules is still necessary. Epigallocatechin molecules, a green tea polyphenol, have shown great virucidal potential against flaviviruses, including DENV, WNV, and ZIKV. The interaction of EGCG with the viral envelope protein and viral protease, mainly identified by computational studies, describes the interaction of these molecules with viral proteins; however, how the viral NS2B/NS3 protease interacts with epigallocatechin molecules is not yet fully deciphered. Consequently, we tested the antiviral potential of two epigallocatechin molecules (EGC and EGCG) and their derivative (AcEGCG) against DENV, YFV, WNV, and ZIKV NS2B/NS3 protease. Thus, we assayed the effect of the molecules and found that a mixture of the molecules EGC (competitive) and EGCG (noncompetitive) inhibited the virus protease of YFV, WNV, and ZIKV more effectively with IC50 values of 1.17 ± 0.2 µM, 0.58 ± 0.07 µM, and 0.57 ± 0.05 µM, respectively. As these molecules fundamentally differ in their inhibitory mode and chemical structure, our finding may open a new line for developing more effective allosteric/active site inhibitors to combat flaviviruses infection.

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Section: Introductionmentioning

confidence: 99%

The Importance of Epigallocatechin as a Scaffold for Drug Development against Flaviviruses

et al. 2023

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“…In a study on hepatitis B virus (HBV) transgenic mice, the HBV antigen was found to interfere with lipid metabolism in the liver ( 5 ). The HBV viral envelope was found to absorb external lipids from host cells to meet the needs of the viral lipid membranes ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

Plasma metabonomics of classical swine fever virus-infected pigs

Liao,

Hu,

Wang

et al. 2023

Front. Vet. Sci.

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Classical swine fever (CSF) is an infectious disease caused by Classical swine fever virus (CSFV), which is characterized by depression, high fever, extensive skin bleeding, leukopenia, anorexia, alternating constipation, and diarrhea. Hemorrhagic infarction of the spleen is the main characteristic pathological change following CSFV infection. Large-scale outbreaks of CSF are rare in China and are mainly distributed regionally. The clinical symptoms of CSF are not obvious, and show variation from typical to atypical symptoms, which makes diagnosis based on clinical symptoms and pathology challenging. In recent years, the incidence of CSF-immunized pig farms in China has increased and new CSFV gene subtypes have appeared, posing new challenges to the prevention and control of CSF in China. Changes in metabolites caused by viral infection reflect the pathogenic process. Metabonomics can reveal the trace metabolites of organisms; however, plasma metabonomics of CSFV-infected pigs have rarely been investigated. Therefore, we used an established pig CSFV infection model to study changes in plasma metabolites. The results showed significant differences in forty-five plasma metabolites at different time periods after CSFV infection in pigs, with an increase in twenty-five metabolites and a decrease in twenty metabolites. These changed metabolites were mainly attributed to the tricarboxylic acid cycle, amino acid cycle, sugar metabolism, and fat metabolism. Thirteen metabolic pathways changed significantly in CSFV-infected pigs, including tricarboxylic acid cycle, inositol phosphate metabolism, glycine, serine and threonine metabolism,lysine degradation, alanine, aspartate and glutamic acid metabolism, pantothenate and CoA biosynthesis, β-alanine metabolism, lysine degradation, arginine and proline metabolism, glycerolipid metabolism, phenylalanine metabolism, arachidonic acid metabolism, linoleic acid metabolism. Among these, changes in fatty acid biosynthesis and metabolism occurred at all time periods post-infection. These results indicate that CSFV infection in pigs could seriously alter metabolic pathways.

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“…The pathogenesis of febrile seizures involves an intricate interplay between immune-inflammatory processes, activation of cytokines, and genetic factors [6] . The regulation of febrile responses is significantly influenced by cytokines with proinflammatory and anti-inflammatory properties, such as interleukin-1, interleukin-6, and tumor necrosis factor [7] .…”

Section: Introductionmentioning

confidence: 99%

Serum Level of Interleukin 6 in Children with Febrile Seizures

Ahmed,

Elsayed,

Abd-Elmotalp

et al. 2023

International Journal of Medical Arts

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Article informationBackground: Febrile seizures [FSs] are frequently observed seizure occurrences during childhood, making them the most prevalent form of seizures in this age group. The activation of the cytokine network is known to play a substantial role in the development of febrile seizures. It is hypothesized that the activation and subsequent release of Interleukin [IL]-6 may be responsible for the induction of fever in individuals experiencing febrile seizures. Interleukin-6 [IL-6] is widely recognized as a pivotal cytokine in the pathogenesis of febrile seizures.

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Review of -omics studies on mosquito-borne viruses of the Flavivirus genus

Cited by 8 publications

References 187 publications

The Importance of Epigallocatechin as a Scaffold for Drug Development against Flaviviruses

The Importance of Epigallocatechin as a Scaffold for Drug Development against Flaviviruses

Plasma metabonomics of classical swine fever virus-infected pigs

Serum Level of Interleukin 6 in Children with Febrile Seizures

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