Review of polysaccharide particle-based functional drug delivery

Barclay, Thomas G.; Day, Candace M.; Petrovsky, Nikolai; Garg, Sanjay

doi:10.1016/j.carbpol.2019.05.067

Cited by 294 publications

(179 citation statements)

References 209 publications

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“…Mucoadhesiveness of polysaccharides can be advantageous for drug uptake via the prolonged contact between the mucosal surface and drug delivery carriers. Polysaccharide-based delivery systems also have some additional advantages including availability at large scale, relatively low cost, low toxicity and immunogenicity, high biocompatibility, and biodegradability [55,59]. Consequently, the polysaccharide-based, microbiota-triggered system is promising strategy for colon-specific drug delivery.…”

Section: Polysaccharide-based Systemsmentioning

confidence: 99%

“…Consequently, the polysaccharide-based, microbiota-triggered system is promising strategy for colon-specific drug delivery. However, polysaccharides-based delivery systems also have some potential drawbacks, which include broad range of molecular weights and variable chemistry of polysaccharides [59,60]. In addition, low solubility in most organic solvents limits the chemical modification of polysaccharides, while hydrophilicity and excessive aqueous solubility of polysaccharides may cause the early and undesirable drug release in the upper GI tract [60,61].…”

Section: Polysaccharide-based Systemsmentioning

confidence: 99%

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Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements

et al. 2020

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Colon targeted drug delivery systems have gained a great deal of attention as potential carriers for the local treatment of colonic diseases with reduced systemic side effects and also for the enhanced oral delivery of various therapeutics vulnerable to acidic and enzymatic degradation in the upper gastrointestinal tract. In recent years, the global pharmaceutical market for biologics has grown, and increasing demand for a more patient-friendly drug administration system highlights the importance of colonic drug delivery as a noninvasive delivery approach for macromolecules. Colon-targeted drug delivery systems for macromolecules can provide therapeutic benefits including better patient compliance (because they are pain-free and can be self-administered) and lower costs. Therefore, to achieve more efficient colonic drug delivery for local or systemic drug effects, various strategies have been explored including pH-dependent systems, enzyme-triggered systems, receptor-mediated systems, and magnetically-driven systems. In this review, recent advancements in various approaches for designing colon targeted drug delivery systems and their pharmaceutical applications are covered with a particular emphasis on formulation technologies.

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Section: Polysaccharide-based Systemsmentioning

confidence: 99%

Section: Polysaccharide-based Systemsmentioning

confidence: 99%

Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements

et al. 2020

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“…The phenomena in which TAM can be used as a targeting vector, is illustrated in Figure 7. TAM-guided nanosystems can actively recognise and bind selectively to membrane-localized-ER, initiating receptor-mediated cellular internalisation processes [132][133][134]. By using TAM as a targeting vector, nanosystems can achieve dual functions, allowing TAM to act synergistically with other therapeutic agents to kill cancer cells and to induce internalisation of the system into ER+ cancer cells.…”

Section: Tam As a Targeting Vectormentioning

confidence: 99%

“…By conjugating TAM at the distal end of various nanosystems containing other therapeutic materials (including different drugs), selective delivery and receptor-mediated cellular internalisation of incorporated materials can be initiated [132][133][134]. Image adapted from Barclay et al [134]. The ability of TAM to be a targeting agent was first proven by its ability to deliver fluorescent dyes into tumours, through the conjugation of TAM with various fluorophores, as seen in Figure 8.…”

Section: Tam As a Targeting Vectormentioning

confidence: 99%

Novel Tamoxifen Nanoformulations for Improving Breast Cancer Treatment: Old Wine in New Bottles

et al. 2020

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Breast cancer (BC) is one of the leading causes of death from cancer in women; second only to lung cancer. Tamoxifen (TAM) is a hydrophobic anticancer agent and a selective estrogen modulator (SERM), approved by the FDA for hormone therapy of BC. Despite having striking efficacy in BC therapy, concerns regarding the dose-dependent carcinogenicity of TAM still persist, restricting its therapeutic applications. Nanotechnology has emerged as one of the most important strategies to solve the issue of TAM toxicity, owing to the ability of nano-enabled-formulations to deliver smaller concentrations of TAM to cancer cells, over a longer period of time. Various TAM-containing-nanosystems have been successfully fabricated to selectively deliver TAM to specific molecular targets found on tumour membranes, reducing unwanted toxic effects. This review begins with an outline of breast cancer, the current treatment options and a history of how TAM has been used as a combatant of BC. A detailed discussion of various nanoformulation strategies used to deliver lower doses of TAM selectively to breast tumours will then follow. Finally, a commentary on future perspectives of TAM being employed as a targeting vector, to guide the delivery of other therapeutic and diagnostic agents selectively to breast tumours will be presented.

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“…They have ability for chemical modification and enable easy constructions of particles and hydrogel for delivery purposes. These can also increase the aqueous solubility of the drug and enhances the stability of drugs and other unstable therapeutics such as proteins [4]. Gums have a property of film-forming and used in the preparation of breath films, cough strips, transdermal film, buccal film and sore throat strips.…”

Section: Introductionmentioning

confidence: 99%

Non-invasive drug delivery system for the delivery of protein/peptide using neem gum and its derivatives

2020

Biointerface Res Appl Chem

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The present investigation is continuation of author’s previous work. In previous work, the author was prepared acrylamide grafted copolymer of neem gum and carboxymethylatedneem gum derivatives. Neem gum polysaccharide (NGP) and its derivatives viz. acrylamide grafted neem gum (NGP-g-Am) and carboxymethylated neem gum (CMNGP) were explored as film forming agent for transdermal delivery of protein/peptide drug (albumin). It was observed that films were not prepared at all the concentrations of NGP with a given concentration range. Studies show that film cannot be prepared using CMNGP even at ahigher concentration of polymer (2 % w/v solution). So only acrylamide grafted neem gum based film were prepared and evaluated. Transdermal films were prepared by using solvent casting method. The developed films were evaluated for various parameters such as drug content, folding endurance, thickness, weight variation, surface pH, moisture uptake, in vitro drug release study and ex-vivo permeation study. The films showed more than 300 folding endurance which demonstrated the good mechanical strength of film. It was also observed that after permeation studies small cracks were also formed in the films. Fabricated films were able to deliver drug upto 7 h. Drug release study and drug permeation studies showed that formulations followed zero order and KorsmeyerPepass model of kinetics. It can be concluded from the findings of the results that acrylamide graft copolymers of neem gum were able to deliver protein/peptide drugs through transdermal route.

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Review of polysaccharide particle-based functional drug delivery

Cited by 294 publications

References 209 publications

Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements

Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements

Novel Tamoxifen Nanoformulations for Improving Breast Cancer Treatment: Old Wine in New Bottles

Non-invasive drug delivery system for the delivery of protein/peptide using neem gum and its derivatives

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