“…• Clinical feature: Variola is characterized by a prodromal period with fever, chills, vomiting, abdominal pain, malaise, and backache (Diven 2001), followed by the occurrence of a rash. Lesions appear initially on the palms, soles, and oral mucosa with centrifugal extension (Morand et al 2017), start as macules and evolve to papules, deep vesicles, pustules, and crusts that heal with scars. Characteristically, lesions are in the same stage of development at any time (Diven 2001).…”