Review of renal cell carcinoma with rhabdoid features with focus on clinical and pathobiological aspects

Karashima, Takashi; Inoue, Keiji; Kasajima, Atsuko; Ohe, Chisato; Kawakami, Fumi; Mikami, Shuji; Matsuura, Keiko; Moriyama, Masatsugu; Nagashima, Yoji; Petersson, Fredrik; López, José I.; Cohen, Ronald J.; Michal, Michal; Hes, Ondřej

doi:10.5114/pjp.2015.51147

Cited by 64 publications

(97 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In contrast, chromophobe RCC (5%) and the benign oncocytoma (3%-7%) arise from the intercalating cells of the collecting ducts of the kidney. 1 The clinical outcome of RCC patients is highly variable. Due to the lack of symptoms approximately one-third RCC patients have already an advanced disease at the time of diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Immune signature of tumor infiltrating immune cells in renal cancer

et al. 2015

View full text Add to dashboard Cite

Tumor-associated immune cells have been discussed as an essential factor for the prediction of the outcome of tumor patients. Lymphocyte-specific genes are associated with a favorable prognosis in colorectal cancer but with poor survival in renal cell carcinoma (RCC). Flow cytometric analyses combined with immunohistochemistry were performed to study the phenotypic profiles of tumor infiltrating lymphocytes (TIL) and the frequency of T cells and macrophages in RCC lesions. Data were correlated with clinicopathological parameters and survival of patients. Comparing oncocytoma and clear cell (cc)RCC, T cell numbers as well as activation-associated T cell markers were higher in ccRCC, whereas the frequency of NK cells was higher in oncocytoma. An intratumoral increase of T cell numbers was found with higher tumor grades (G1:G2:G3/4 D 1:3:4). Tumor-associated macrophages slightly increased with dedifferentiation, although the macrophage-to-T cell ratio was highest in G1 tumor lesions. A high expression of CD57 was found in T cells of early tumor grades, whereas T cells in dedifferentiated RCC lesions expressed higher levels of CD69 and CTLA4. TIL composition did not differ between older (>70 y) and younger (<58 y) patients. Enhanced patients' survival was associated with a higher percentage of tumor infiltrating NK cells and Th1 markers, e.g. HLA-DRC and CXCR3C T cells, whereas a high number of T cells, especially with high CD69 expression correlated with a worse prognosis of patients. Our results suggest that immunomonitoring of RCC patients might represent a useful tool for the prediction of the outcome of RCC patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Immune signature of tumor infiltrating immune cells in renal cancer

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Большин-ство обнаруженных очагов -простые паренхиматоз-ные кисты почки. МКПННЗП составляют от 4 до 15 % всех случаев ПКР [9]. В настоящем исследовании она зарегистрирована в 32 (5,44 %) из 588 случаев ПКР.…”

Section: Discussionunclassified

“…Большинство случаев МКПННЗП диагностируют случайно при профилактическом обследовании, так как симптомы, характерные для других неоплазий ПКР (боль, гематурия и артериальная гипертензия), описа-ны в литературе довольно редко [4,5,9]. В настоящем исследовании только 8 (25 %) больных имели клини-ческие симптомы в виде тянущей боли в пояснице на стороне опухолевого поражения, что могло быть связано с проявлением сопутствующей мочекамен-ной болезни, которую нам удалось диагностировать у 9 (28,12 %) пациентов.…”

Section: Discussionunclassified

“…В литера-туре не описаны случаи развития рецидива или мета-стазов МКПННЗП [15]. Кроме того, при анализе гисто-логического материала не обнаруживаются сосудистая или экстракапсулярная инвазия, саркоматоидные из-менения, низкая дифференцировка опухоли, что под-тверждается и в нашем исследовании [9]. Заключение Таким образом, больные МКПННЗП обладают наилучшим онкологическим прогнозом среди пациен-тов с ПКР.…”

Section: Discussionunclassified

See 1 more Smart Citation

Multilocular cystic renal neoplasm of low malignant potential: experience of N.N. Lopatkin Scientific Research Institute of Urology and Interventional Radiology

Алексеев¹,

Shevchuk²,

Ефремов³

et al. 2017

Cancer Urology

View full text Add to dashboard Cite

show abstract

“…They suggested that the sarcomatoid portion is derived from metaplastic transformation of carcinoma. Sarcomatoid RCCs have also been referred to as metaplastic carcinomas or spindle cell carcinomas 2 . SRCC is currently defined in the 2004 World Health Organization (WHO) classification of renal tumors as any histologic type of RCC containing foci of high grade malignant spindle cells 3 .…”

Section: Introductionmentioning

confidence: 99%

Report of a Rare Case of Sarcomatoid Renal Cell Carcinoma

Hossain

Ahmed

Bhattacharjee

et al. 2014

Chatt Maa Shi Hosp Med Coll J

View full text Add to dashboard Cite

A 50 years old non-smoker female with the history of right flank pain and hematuria surgically treated with right sided radical nephrectomy. Macroscopically it showed a large growth located at the lower pole of the right kidney. Histologically the tumor was composed of exuberant sarcomatous elements predominantly malignant fibrous histiocytoma like pattern and diagnosed as sarcomatoid renal cell carcinoma. There was no scope for immunohistological analysis of that tumor in our setup. It is important to recognize the sarcomatoid component in the renal tumors because of its aggressive behavior and adverse prognosis. We report herein a case of sarcomatoid renal cell carcinoma histomorphogically.

show abstract

Review of renal cell carcinoma with rhabdoid features with focus on clinical and pathobiological aspects

Cited by 64 publications

References 40 publications

Immune signature of tumor infiltrating immune cells in renal cancer

Immune signature of tumor infiltrating immune cells in renal cancer

Multilocular cystic renal neoplasm of low malignant potential: experience of N.N. Lopatkin Scientific Research Institute of Urology and Interventional Radiology

Report of a Rare Case of Sarcomatoid Renal Cell Carcinoma

Contact Info

Product

Resources

About