Review of surgical treatment of insular gliomas: challenges and opportunities

Pitskhelauri, D I; Bykanov, Andrey; Zhukov, V Yu; Kachkov, I A; Буклина, С Б; Tonoyan, A S

doi:10.17116/neiro2015792111-116

Cited by 8 publications

(4 citation statements)

References 34 publications

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“…The specific treatment modalities for glioma are surgery, radiation, and chemotherapy. Although surgery has made some progress [ 1 ], it is challenging to eradicate glioma because of its aggressiveness and high recurrence rate; radiotherapy is not sensitive to most glioma tumors, and some sensitizers need to be added to assist in treatment. Although traditional chemotherapy is not as fast as surgery and radiotherapy, chemotherapy is still essential.…”

Section: Introductionmentioning

confidence: 99%

HDAC2 Induces DNA Methyltransferase DNMT3B Expression to Regulate the Wnt Signaling Pathway and Thus Promotes Glioma Development and Progression

Ren

Jin

2022

Evidence-Based Complementary and Alternative Medicine

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Purpose. To investigate the role and molecular mechanism of HDAC2 in glioma. Methods. GSE16011, GSE31262, and GSE90598 datasets were used to identify co-expressed genes, GO analysis, and KEGG analysis to identify gene enrichment pathways, and PPI networks were constructed to identify gene interrelationships. HDAC2 enrichment on DNMT3B promoter and DNMT3B enrichment on Bcl2 CpG island was detected by a ChIP assay. The expression, prognosis, and hierarchical distribution of HDAC2, DNMT3B, and Bcl2 were examined in the CGGA database, and the correlation between HDAC2 and DNMT3B, Bcl2, and DNMT3B and Bcl2 was assessed. Results. The HDAC2-DNMT3B-Bcl2 axis is differentially expressed and interacts in gliomas. HDAC2 activates the transcriptional activity of DNMT3B, and DNMT3B inhibits the expression of Bcl2. HDAC2 and DNMT3B are highly expressed in gliomas and have a poor prognosis, while Bcl2 is lowly expressed in gliomas and has a good prognosis. Conclusion. HDAC2 promotes DNMT3B transcriptional repression of Bcl2 expression and Wnt pathway activity, thereby activating glioma cell activity in vitro and in vivo.

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Section: Introductionmentioning

confidence: 99%

HDAC2 Induces DNA Methyltransferase DNMT3B Expression to Regulate the Wnt Signaling Pathway and Thus Promotes Glioma Development and Progression

Ren

Jin

2022

Evidence-Based Complementary and Alternative Medicine

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“…The median residual tumor volume was 6.72 cm 3 (0-55 cm 3 ). Using our classification, a statistically significant association was revealed between the EOR and tumor location (P = .02).…”

Section: Extent Of Tumor Removal-volumetric Analysismentioning

confidence: 99%

“…Three main approaches can be used to the tumors of the insular lobe: transsylvian, transcortical, and combined transcortical-transsylvian approach. 3,5 The recent studies showed that the selection of a surgical approach is still controversial regarding to safety and adequate exposure for maximum tumor resection. 2,3,5,6 There are several classification systems of tumors of the insular lobe.…”

mentioning

confidence: 99%

“…3,5 The recent studies showed that the selection of a surgical approach is still controversial regarding to safety and adequate exposure for maximum tumor resection. 2,3,5,6 There are several classification systems of tumors of the insular lobe. [7][8][9] It has to be mentioned that the prognostic value of Berger-Sanai tumor classification system was applied to patients operated only via the transcortical approach.…”

mentioning

confidence: 99%

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Transsylvian Insular Glioma Surgery: New Classification System, Clinical Outcome in a Consecutive Series of 79 Cases

Pitskhelauri¹,

Bykanov²,

Konovalov³

et al. 2021

Operative Surg.

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BACKGROUND Surgery of insular glial tumors remains a challenge because of high incidence of postoperative neurological deterioration and the complex anatomy of the insular region. OBJECTIVE To explore the prognostic role of our and Berger-Sanai classifications on the extent of resection (EOR) and clinical outcome. METHODS From 2012 to 2017, a transsylvian removal of insular glial tumors was performed in 79 patients. The EOR was assessed depending on magnetic resonance imaging scans performed in the first 48 h after surgery. RESULTS The EOR ≥90% was achieved in 30 (38%) cases and <90% in 49 (62.0%) cases. In the early postoperative period, the new neurological deficit was observed in 31 (39.2%) patients, and in 5 patients (6.3%), it persisted up to 3 mo. We proposed a classification of insular gliomas based on its volumetric and anatomical characteristics. A statistically significant differences were found between proposed classes in tumor volume before and after surgery (P < .001), EOR (P = .02), rate of epileptic seizures before the surgical treatment (P = .04), and the incidence of persistent postoperative complications (P = .03). In the logistic regression model, tumor location in zone II (Berger-Sanai classification) was the predictor significantly related to less likely EOR of ≥90% and the maximum rate of residual tumor detection (P = .02). CONCLUSION The proposed classification of the insular gliomas was an independent predictor of the EOR and persistent postoperative neurological deficit. According to Berger-Sanai classification, zone II was a predictor of less EOR through the transsylvian approach.

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Complication avoidance: resection of the insular glioma complicated by iatrogenic injury to the lenticulostriate artery

Pitskhelauri

Bykanov²

2021

Acta Neurochir

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Review of surgical treatment of insular gliomas: challenges and opportunities

Cited by 8 publications

References 34 publications

HDAC2 Induces DNA Methyltransferase DNMT3B Expression to Regulate the Wnt Signaling Pathway and Thus Promotes Glioma Development and Progression

HDAC2 Induces DNA Methyltransferase DNMT3B Expression to Regulate the Wnt Signaling Pathway and Thus Promotes Glioma Development and Progression

Transsylvian Insular Glioma Surgery: New Classification System, Clinical Outcome in a Consecutive Series of 79 Cases

Complication avoidance: resection of the insular glioma complicated by iatrogenic injury to the lenticulostriate artery

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