Review of the botany, traditional uses, pharmacology, threats and conservation of Zanthoxylum armatum (Rutaceae)

Agnihotri, Saumya; Dobhal, Preeti; Ashfaqullah, Sayyed; Chauhan, Harsh Kumar; Tamta, Sushma

doi:10.1016/j.sajb.2022.08.038

Cited by 8 publications

(6 citation statements)

References 53 publications

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“…There are more than 250 species of the genus Zanthoxylum L. in the world, including 45 species and 13 varieties in China [ 1 ]. Worldwide, the genus is found mainly in Asia, including Central, South, Southeast, and East Asia, but also in Himalayas, Americas, and Africa [ 2 ]. In China, Z. armatum are mainly distributed in the southwestern region, such as Sichuan, Chongqing, Yunnan, and Guangxi [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

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Chemical Composition Variation in Essential Oil and Their Correlation with Climate Factors in Chinese Prickly Ash Peels (Zanthoxylum armatum DC.) from Different Habitats

Qian,

Zhuo,

Peng

et al. 2024

Molecules

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Essential oils are secondary metabolites in plants with a variety of biological activities. The flavor and quality of Zanthoxylum armatum DC. are mainly determined by the essential oil components in the Chinese prickly ash peels. In this study, the correlation between climate change in different regions and the content of essential oils of Z. armatum was investigated using gas chromatography–mass spectrometry (GC/MS) and multivariate statistical analysis. The Z1–24 refers to 24 batches of samples from different habitats. A total of 145 essential oils were detected in 24 batches of samples, with the highest number of terpene species and the highest content of alcohol. The relative odor activity (ROAV) values identified nine main flavor compounds affecting the odor of Z. armatum. Linalool, decanal, and d-limonene were the most critical main flavor compounds, giving Z. armatum a spicy, floral, oily, and fruity odor. The results of hierarchical cluster analysis (HCA) and principal component analysis (PCA) classified Z5 into a separate group, Z2 and Z7 were clustered into one group, and the rest of the samples were classified into another group. Correlation analysis and path analysis showed that temperature and precipitation were the main climatic factors affecting essential oils. Comparisons can be made with other plants in the genus Zanthoxylum to analyze differences in essential oil type and content. This study contributes to the identification of Z. armatum quality, promotes the accumulation of theories on the effects of climatic factors on essential oils, and enriches the site selection and breeding of Z. armatum under similar climatic conditions.

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Section: Introductionmentioning

confidence: 99%

“…Z. armatum peels, as an herbal medicine, can relieve fever, appetite, toothache, rheumatism, diabetes, etc. [ 2 , 5 ]. It is commonly used as an edible spice for making kimchi, hot pot seasoning, and cooking traditional Chinese dishes and is one of the “Eight Major Seasonings” in China.…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition Variation in Essential Oil and Their Correlation with Climate Factors in Chinese Prickly Ash Peels (Zanthoxylum armatum DC.) from Different Habitats

Qian,

Zhuo,

Peng

et al. 2024

Molecules

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“…citral, b-myrcene and geraniol) in different in vitro and in vivo systems (Aboagye et al, 2021;Cheel et al, 2005;Faheem et al, 2022;Mitić-Ćulafić et al, 2009;Pereira et al, 2009;Rabbani et al, 2006;Tapia et al, 2007). Moreover, geraniol has been found to reduce the proliferative activity of Caco-2 human colon and MCF-7 human breast cancer cells lines (Agnihotri et al, 2022;Zhi et al, 2021). In addition, lemongrass ethanolic extract given orally to male Fischer 344 rats inhibited both colonic aberrant crypt foci (ACF) and hepatic glutathione S-transferase placental form (GST-P) positive foci development induced by carcinogens azoxymethane and diethylnitrosamine, respectively (Nomier et al, 2021;Okada et al, 2021;Zhi et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Protective effects of lemongrass (Cymbopogon citratus STAPF) extract mediated mitochondrial fission and glucose uptake inhibition in SW1417

Alwaili

2023

Food Sci. Technol

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This study investigated the anticarcinogenic effect of lemongrass extract on human SW1417 colon cancer cells. SW1417 cells were cultured and allocated into five groups to apply the treatment with the lemongrass extract using 5 separate fluctuated concentrations: 0, 50, 100, 150 and 200 μg/mL for 24 h. The mRNA expressions of the oxidative pressure genes (HO-1 and NQO1) were measured using the RT-PCR technique. Additionally, mitochondrial morphology was evaluated using Biotium (100 nM MitoView™ 405-Blue) within a free culture. The antitumor activity value (IC 50 ) in SW1417 cells was done at 150 µg/mL. Besides, the changes of mitochondrial morphology in the treated SW1417 cells at all the concentrations of lemongrass extract were markedly observed as mitochondrial fission, which increased with increasing the concentrations and led to an apoptotic effect. For more validation, mRNA levels of the oxidative pressure genes HO-1 and NQO1 were confirmed the obtained data, HO-1 and NQO1 genes expressions recorded significant (P < 0.05) increase which associated with increasing the concentrations of lemongrass extract standardized to β-actin housekeeping gene and contrasted to untreated cells (0 μg/mL). In conclusion, our findings indicate that lemongrass extract provided an anticarcinogenic action against the cell proliferation of human colon cancer cells.

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“…[33] However, the biological activities of the essential oils from the leaves and stems of this plant have been poorly studied, while the essential oils from the leaves and other parts of the species Z. armatum of the same genus have been extensively studied with many remarkable activity. [34][35][36][37] Considering that this plant is widely distributed in Vietnam, we conducted this study with the aim to elucidate and compare the composition of essential oils in leaves and stems of Z. acanthopodium collected in Bidoup-Nui Ba National Park, Lam Dong Province, Vietnam. Their antibacterial (on six bacterial strains), antifungal (on Candida albican), NO production inhibition in LPS-stimulated RAW 264.7 cells, and cytotoxic activity against three cancer cell lines (SK-LU-1, MCF-7, and HepG2) were evaluated.…”

Section: Introductionmentioning

confidence: 99%

“…Terpenoids are known to be the main constituent of the essential oil from its leaves collected in India [32] and from the aerial parts of the plant in China [33] . However, the biological activities of the essential oils from the leaves and stems of this plant have been poorly studied, while the essential oils from the leaves and other parts of the species Z. armatum of the same genus have been extensively studied with many remarkable activity [34–37] . Considering that this plant is widely distributed in Vietnam, we conducted this study with the aim to elucidate and compare the composition of essential oils in leaves and stems of Z. acanthopodium collected in Bidoup‐Nui Ba National Park, Lam Dong Province, Vietnam.…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition, Antimicrobial, Nitric Oxide Inhibition and Cytotoxic Activity of Essential Oils from Zanthoxylum acanthopodium DC. Leaves and Stems from Vietnam

Diep,

Dung,

Trung

et al. 2023

Chemistry & Biodiversity

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This study was aimed to investigate the chemical composition and biological activities of leaf and stem essential oils of Zanthoxylum acanthopodium DC. from Vietnam. Their chemical composition was analyzed by GC/MS. Antimicrobial activities were evaluated by microdilution broth assay. Anti‐inflammatory activity was evaluated by the ability to inhibit nitric oxide production in macrophage cells. Cytotoxic activity was evaluated using the sulforhodamine B assay on three human cancer cell lines. Forty‐four compounds were identified in the leaf oil, among which dehydroaromadendrane (23.4 %), (E)‐carpacin (17.6 %), 2‐tridecanone (12.2 %), and 9‐methyl‐2‐decanone (11.8 %) were the most abundant. The stem oil contained fifty‐five identified constituents, mainly γ‐gurjunene (51.1 %) and butyl acetate (11.8 %). Both oils exhibited inhibitory effects on three bacterial strains, namely S. aureus, E. coli, P. aeruginosa and a fungal strain C. albican, while showed insignificant effects on B. subtilis, L. fermentum, and S. enterica. Both oils showed weak NO production inhibition in LPS‐induced RAW264.7 cells, but exhibited potent cytotoxic activity against all three tested cell lines SK‐LU‐1, MCF‐7, and HepG2 with the IC50 values ranging from 16.03±0.77 to 35.60±1.62 μg/mL. This is the first report on the antimicrobial, anti‐inflammatory and cytotoxic activities of essential oils from the leaves and stems of Z. acanthopodium.

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Review of the botany, traditional uses, pharmacology, threats and conservation of Zanthoxylum armatum (Rutaceae)

Cited by 8 publications

References 53 publications

Chemical Composition Variation in Essential Oil and Their Correlation with Climate Factors in Chinese Prickly Ash Peels (Zanthoxylum armatum DC.) from Different Habitats

Chemical Composition Variation in Essential Oil and Their Correlation with Climate Factors in Chinese Prickly Ash Peels (Zanthoxylum armatum DC.) from Different Habitats

Protective effects of lemongrass (Cymbopogon citratus STAPF) extract mediated mitochondrial fission and glucose uptake inhibition in SW1417

Chemical Composition, Antimicrobial, Nitric Oxide Inhibition and Cytotoxic Activity of Essential Oils from Zanthoxylum acanthopodium DC. Leaves and Stems from Vietnam

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