Review of the validated HPLC and LC‐MS/MS methods for determination of drugs used in clinical practice for Alzheimer's disease

Sulochana, Suresh P.; Sharma, Kuldeep; Mullangi, Ramesh; Kumar, S. Sathesh

doi:10.1002/bmc.3116

Cited by 28 publications

(11 citation statements)

References 63 publications

(246 reference statements)

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“…This period covered the time to reach steady-state plasma concentration of donepezil. The steady-state plasma concentration of donepezil was determined by using reversed-phase ultra performance liquid chromatography with photo diode array (UPLC-PDA) detection with a minor modification 23. Diphenhydramine was used as an internal standard 24.…”

Section: Methodsmentioning

confidence: 99%

Influence of CYP2D6, CYP3A5, ABCB1, APOE polymorphisms and nongenetic factors on donepezil treatment in patients with Alzheimer’s disease and vascular dementia

Yaowaluk¹,

Senanarong²,

Limwongse³

et al. 2019

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Purpose This study aims to evaluate the influence of genetic polymorphisms of CYP2D6, CYP3A5, ABCB1 , and APOE genes and nongenetic factors on steady-state plasma concentrations (Cpss) of donepezil and therapeutic outcomes in Thai patients with Alzheimer’s disease (AD) and vascular dementia (VAD). Patients and methods Eighty-five dementia patients who received donepezil for at least six months were recruited. CYP2D6, CYP3A5, ABCB1 , and APOE polymorphisms were genotyped. Cpss of donepezil was measured. Association of genetic and non-genetic factors with Cpss and clinical outcomes of donepezil (cognitive function as measured by the Thai Mental State Examination score; TMSE) were determined by using univariate and multivariate analysis. Results Both univariate and multiple linear regression analysis indicated that only CYP2D6*10 allele was associated with higher Cpss ( p -value =0.029 and B =0.478, p -value =0.032, respectively) that might influence the clinical outcomes of donepezil. ie, TMSE ( p -value =0.010 and B =4.527, p -value =0.001) and ΔTMSE ( p -value =0.023 and B =4.107, p -value =0.002), especially in patients with AD. Interestingly, concomitant use of memantine was found to be associated with increased Cpss of donepezil ( p -value =0.007 and B =0.511, p -value =0.014). Whereas, co-medication with antidepressant drugs attenuated clinical responses in patients with AD (TMSE: B =−2.719, p -value =0.013 and ΔTMSE: B =−2.348, p -value =0.028). Age was a significant predictor of donepezil response in VAD patients. No significant association of CYP3A5*3, ABCB1 3435C>T or ABCB1 1236C>T, and APOE ε4 genotypes with Cpss or clinical outcomes of donepezil was found in this study. Conclusion Our results suggests that CYP2D6*10 strongly influences Cpss and there is a trend toward better outcomes of donepezil in patients with AD. Nongenetic factors including concomitant drugs treatment might alter Cpss of donepezil or clinical outcomes.

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Section: Methodsmentioning

confidence: 99%

Influence of CYP2D6, CYP3A5, ABCB1, APOE polymorphisms and nongenetic factors on donepezil treatment in patients with Alzheimer’s disease and vascular dementia

Yaowaluk¹,

Senanarong²,

Limwongse³

et al. 2019

PGPM

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“…Donepezil and rivastigmine are two main oral drugs approved by US Drug Administration, which are used for the treatment of Alzheimer's disease. Quantitation of these drugs in various biological matrixes and monitoring them in a long‐term treatment are essential to titer the dose of these drugs and ensure the patient's compliance . On the other hand, nowadays certain pharmaceuticals are attracting attention as a potentially new class of water pollutants.…”

Section: Introductionmentioning

confidence: 99%

Simple determination of some antidementia drugs in wastewater and human plasma samples by tandem dispersive liquid–liquid microextraction followed by high‐performance liquid chromatography

Mirparizi

Rajabi

Asghari

2018

J of Separation Science

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In this work, a simple method, namely, tandem dispersive liquid-liquid microextraction, with a high sample clean-up is applied for the rapid determination of the antidementia drugs rivastigmine and donepezil in wastewater and human plasma samples. This method, which is based on two consecutive dispersive microextractions, is performed in 7 min. In the method, using a fast back-extraction step, the applicability of the dispersive microextraction methods in complicated matrixes is conveniently improved. This step can be performed in less than 2 min, and very simple tools are required for this purpose. To achieve the best extraction efficiency, optimization of the variables affecting the method was carried out. Under the optimized experimental conditions, the relative standard deviations for the method were in the range of 6.9-8.7%. The calibration curves were obtained in the range of 2-1100 ng/mL with good correlation coefficients, higher than 0.995, and the limits of detection ranged between 0.5 and 1.0 ng/mL.

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“…In addition, identification of normal physiological functions of Aβ is an extremely important emerging issue, as many therapeutic strategies used for the treatment of AD point to prevent Aβ production or to increase Aβ clearance from the brain. Consistently, it cannot be, so far, ruled out that these strategies does not interfere with important physiological functions ( Abramov et al, 2009 ; Kang et al, 2013 ; Bukanova et al, 2014 ; Mizoi et al, 2014 ; Ponnayyan Sulochana et al, 2014 ).…”

Section: Alzheimer’s Diseasementioning

confidence: 99%

Osteoporosis and alzheimer pathology: Role of cellular stress response and hormetic redox signaling in aging and bone remodeling

et al. 2014

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Alzheimer’s disease (AD) and osteoporosis are multifactorial progressive degenerative disorders. Increasing evidence shows that osteoporosis and hip fracture are common complication observed in AD patients, although the mechanisms underlying this association remain poorly understood. Reactive oxygen species (ROS) are emerging as intracellular redox signaling molecules involved in the regulation of bone metabolism, including receptor activator of nuclear factor-κB ligand-dependent osteoclast differentiation, but they also have cytotoxic effects that include lipoperoxidation and oxidative damage to proteins and DNA. ROS generation, which is implicated in the regulation of cellular stress response mechanisms, is an integrated, highly regulated, process under control of redox sensitive genes coding for redox proteins called vitagenes. Vitagenes, encoding for proteins such as heat shock proteins (Hsps) Hsp32, Hsp70, the thioredoxin, and the sirtuin protein, represent a systems controlling a complex network of intracellular signaling pathways relevant to life span and involved in the preservation of cellular homeostasis under stress conditions. Consistently, nutritional anti-oxidants have demonstrated their neuroprotective potential through a hormetic-dependent activation of vitagenes. The biological relevance of dose–response affects those strategies pointing to the optimal dosing to patients in the treatment of numerous diseases. Thus, the heat shock response has become an important hormetic target for novel cytoprotective strategies focusing on the pharmacological development of compounds capable of modulating stress response mechanisms. Here we discuss possible signaling mechanisms involved in the activation of vitagenes which, relevant to bone remodeling and through enhancement of cellular stress resistance provide a rationale to limit the deleterious consequences associated to homeostasis disruption with consequent impact on the aging process.

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Review of the validated HPLC and LC‐MS/MS methods for determination of drugs used in clinical practice for Alzheimer's disease

Cited by 28 publications

References 63 publications

<p>Influence of <em>CYP2D6, CYP3A5, ABCB1, APOE</em> polymorphisms and nongenetic factors on donepezil treatment in patients with Alzheimer’s disease and vascular dementia</p>

<p>Influence of <em>CYP2D6, CYP3A5, ABCB1, APOE</em> polymorphisms and nongenetic factors on donepezil treatment in patients with Alzheimer’s disease and vascular dementia</p>

Simple determination of some antidementia drugs in wastewater and human plasma samples by tandem dispersive liquid–liquid microextraction followed by high‐performance liquid chromatography

Osteoporosis and alzheimer pathology: Role of cellular stress response and hormetic redox signaling in aging and bone remodeling

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