Review of Therapeutic Procedures for Removal of Inhaled Radioactive Materials

Tombropoulos, Elias G.

doi:10.1097/00004032-196412000-00047

Cited by 8 publications

(4 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar results were obtained for DTPA whether administered in a lavage solution or intr<ivenously. For 144Ce0, prepared by calcination at 40O0C, Tombropoulos (1964) reported less effectiveness for rcmoval by IITPA than seen for 14*CeO, prepared by peroxide precipitation.…”

Section: Introductionmentioning

confidence: 73%

Removal of 144Ce in Fused Clay Particles from the Beagle Dog Lung by Bronchopulmonary Lavage

Bb¹,

Ba²,

Ro³

et al. 1974

Health Physics

View full text Add to dashboard Cite

The effectiveness of repeated bronchopulmonary lavage for removing inhaled l4We fused clay particles from the lungs of Beagle dogs was investigated. Twelve Beagle dogs were exposed to a 144Ce fused clay aerosol resulting in initial lung burdens ranging from 47-64 pCi/kg body weight. Eight received 10 saline lavage treatments, five on each lung over a 56-day period. At the end of each lavage, they also received 50 mg of calcium diethylenetriaminepentaacetic acid (DTPA) intravenously. Four dogs received no treatment. A second group of four dogs was exposed to an aeorsol of fused clay only and given 10 lung lavages over a 56-day period. I n the eight treated dogs, an average of 44% of initial lung burden was removed by the 10 lavage procedures. Recovery from two of these eight dogs was considerably lower, 23 and 27%, than the average of the remaining 6, 51%. The reason for this has not been established. Examination of the urinary excretion showed that although the DTPA injections increased urinary excretion 10 fold, this difference between the treated and untreated dogs accounted for only 1.6% of the initial lung burden. Thus, for 144Ce inhaled in this form, the lavage procedure was 28 times more effective in removing '44Ce from the body than were the DTPA injections. The reduction in initial lung burden over a 56-day treatment period resulted in a decrease of the cumulative radiation dose to the lung, at 90 days and infinity, to 53 and 57%, respectively, of that found for the untreated dogs. No significant clinical changes due to treatment were observed in these animals. All of the dogs in this study were alive at 90 days post-exposure and are now under observation in the colony.

show abstract

Section: Introductionmentioning

confidence: 73%

Removal of 144Ce in Fused Clay Particles from the Beagle Dog Lung by Bronchopulmonary Lavage

Bb¹,

Ba²,

Ro³

et al. 1974

Health Physics

View full text Add to dashboard Cite

show abstract

“…The remaining cerium and tuthenium were retainT wit biological half-lives of several years. Calcined Ce 4-Pr 4402 translocated to the liver and skeleton more slowly than Ce -Pr 02 precipitated with peroxide; calcined 144 144…”

Section: Discussionmentioning

confidence: 99%

“…hundred to 300 tiCi.of calcined Ce -Pr 02 (dogs 10 through 15) lowered lymphocyte levels markedly, but neutrophil levels, in exposed dogs were at least as high as in controls. The comparatively small amounts of initi- lated more rapidly in the liver and skeleton than is calcined Ce -Pr 0 2' 144 144…”

mentioning

confidence: 99%

See 1 more Smart Citation

Hanford Biology Research Annual Report for 1964

Thompson¹,

Woods²

1965

View full text Add to dashboard Cite

BNWL-122 Results are reported from a third survey of radioactivity in northern 137 Alaskan natives and their foods. Eskimo Cs levels in the summer of 1964 were about double those measured in 1963, but still well below any J level which should be cause for concern. Seasonal fluctuations as determined by caribou hunting patterns, and caribou feeding patterns can now be fairly clearly defined. Food chain, precipitation, and radionuclide deposition interrelationships are also described for a continuing general survey in the State of Washington and in a carefully studied chdatgrass-community. Looking toward a broadened study of the dynamic balance of radionuclides in the Columbia River, preliminary results are reported on the 32 role of plankton and periphyton in the accumulation and transport of P 65 and Zn. Further studies of the economically important columnaris disease in fish have led to the demonstration of anti-columnaris titers in fish exposed to the organism. A sampling program showed that such titers exist in the majority of Columbia River fish. Application of immunological techniques in this area opens many exciting possibilities for study and control. The third Hanford Biology Symposium, on Inhaled Radioactive Particles and Gases, was held on May 4-6, 1964, and was attended by some 170 visitors, 20 representing seven foreign countries: The complete proceedings of this symposium were published as the December 1964 issue of Health Physics. The 1965 symposium will be on Radiation and Terrestrial Ecosystems, and planned for 1966 is a symposium on Gastrointestinal Radiation Effects.

show abstract