Review of twelve West Africa medicinal plants: Active phytochemical combinations in direct biochemically wound healing process

Edefia, Akpalo; Tété‐Bénissan, Amivi; Awaga, Kwami Lumo; Akpagana, Koffi

doi:10.5897/jmpr2015.5849

Cited by 9 publications

(6 citation statements)

References 50 publications

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“…This study has shown that S. longiflora possess some analgesic properties using the force gauge machine on experimental cutaneous wounds which was due to the flavonoids component of the secondary metabolites as described by Akpalo et al (2015), Fakhim et al (2015) and Christian et al (2016). Flavonoids are free radical scavengers due to their high reactivity as hydrogen or electron donors.…”

Section: Analgesic Propertiesmentioning

confidence: 69%

Analgesic effect of Sansevieria longiflora (Sim) water extract and xylocaine cream on surgical wound incision in rats

Kilani

Hassan

Fadason

et al. 2020

Bangladesh J. Sci. Ind. Res.

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Analgesic effect of Sansevieria longiflora (S. longiflora) on surgically created wound was studied. Phytochemical screening of the crude water extracts was carried out following standard procedures. Sansevieria longiflora leaves was heated and the sap was squeezed into a sample bottle to be used as it was traditional believed. Its water extract was also prepared following standard procedure. Four (4) albino rats consisting of 2 males and 2 females were used for the study. One centimeter full thickness skin incision was created on 4 different locations at the dorsal region of each rat under anaesthesia. Each of the 4 wounds created was topically treated once daily with S. longiflora sap (E), S. longiflora water extract (F), Physiological saline solution (C) and xylocaine cream (G). The treatment regimen was rotated in a clockwise direction on each rat. Pain perception was evaluated with an algometer at 6:00 GMT (morning) and 18:00 GMT (evening) from day 1 post surgery for 5 days. The phytochemical studies revealed that S. longiflora contains carbohydrates, glycoside, saponins, steroids, triterpenes, flavonoids, alkaloids and tannins. Day1 after the surgery, the mean morning value of force (N) required to elicit pain in xylocaine treated wounds (5.2 ± 0.79) were significantly higher (p<0.001) than that of physiological saline solution (2.8 ± 0.29) whereas, not different from that of S. longiflora sap (4.48 ± 0.57) and water extract (4.2 ± 0.6). Similarly, on the day 5 after the surgery, the mean morning value of force (N) required to elicit pain in xylocaine treated wounds were significantly higher (p<0.0001) than that of physiological saline solution (PSS) treated wounds and not different from that of S. longiflora sap and water extract. This showed that S. longiflora sap and water extract possess analgesic effect on incisional wounds. This study serves as a preliminary study on this plant towards searching for potent analgesics that could be used for procedural pain management. Bangladesh J. Sci. Ind. Res.55(2), 99-106, 2020

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Section: Analgesic Propertiesmentioning

confidence: 69%

Analgesic effect of Sansevieria longiflora (Sim) water extract and xylocaine cream on surgical wound incision in rats

Kilani

Hassan

Fadason

et al. 2020

Bangladesh J. Sci. Ind. Res.

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“…Senyawa tanin terkandung dalam EEKBJ dapat menghambat terjadinya nekrosis dengan cara meningkatkan glikogenesis sehingga dapat mencegah penimbunan glukosa dalam darah dan stres oksidatif (Anwar et al, 2022). Tanin juga memiliki kemampuan untuk meningkatkan regenerasi dan organisasi jaringan baru yang rusak akibat nekrosis (Edefia et al, 2015). Adapun efektivitas PLGA-EEKBJ dalam menurunkan jumlah sel nekrosis diduga karena kemampuan nanopartikel PLGA yang dapat mengantarkan berbagai agen terapetik langsung menuju ke sitoplasma sel target tanpa mengalami degradasi selama di dalam tubuh dan memengaruhi sel non-target (Ahmad et al, 2018;Li et al, 2019).…”

Section: Jumlah Sel Nekrosis Tikus Model Diabetesunclassified

Perbaikan Profil Kolesterol dan HistologisJantung Tikus Model Diabetes dengan Nanopartikel Poly(Lactic-Co-Glycolic Acid) -Ekstrak Etanol Kulit Buah Jengkol

Malini,

Firdous,

Madihah

et al. 2023

jveteriner

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Diabetes mellitus merupakan penyakit kelainan metabolisme glukosa akibat defisiensi atau penurunan efektivitas insulin. Kondisi ini memicu terjadinya hiperlipidemia yang ditandai dengan kadar low density lipoprotein (LDL) yang tinggi dan high density lipoprotein (HDL_ rendah serta meningkatkan risiko terkena penyakit jantung. Penelitian ini bertujuan untuk menguji efektivitas nanopartikel poly(lactic-co-glycolic acid) atau PLGA-ekstrak etanol kulit buah jengkol (EEKBJ) dalam memperbaiki profil kolesterol dan kerusakan struktur histologis jantung tikus (Rattus Norvegicus) Wistar model diabetes. Tikus yang digunakan sebanyak 30 ekor yang dibagi menjadi enam kelompok yaitu satu kelompok normal dan lima kelompok diabetes. Induksi model tikus diabetes dilakukan dengan injeksi intravena streptozotocin (STZ) dosis 65 mg/kg BB. Perlakuan yang diberikan adalah KN (Carboxy Methyl Cellulose (CMC) 0,5%), kontrol positif (KP) (STZ+CMC 0,5%), pembanding (Pb) (STZ+Glibenklamid dosis 10 mg/kg BB), P1 (STZ+EEKBJ 770 mg/kg BB), P2 (STZ+EEKBJ 110 mg/kg BB), dan P3 (STZ+nanopartikel PLGA-EEKBJ 110 mg/kg BB) selama 14 hari berturut-turut. Parameter yang diamati adalah kadar kolesterol HDL dan LDL, jumlah sel nekrosis, dan derajat kerusakan pada sel miokardium (degenerasi hidropik, degenerasi lemak, dan infiltrasi sel radang). Uji analisis statistika menggunakan sidik ragam, dilanjutkan dengan uji Kruskal Wallis dan uji jarak berganda Duncan. Hasil penelitian menunjukkan bahwa pemberian nanopartikel PLGA-EEKBJ menurunkan kadar LDL, jumlah sel nekrosis, derajat kerusakan histologis dan meningkatkan kadar kolesterol HDL secara signifikan (p>0,05), Simpulan dari penelitian ini adalah nanopartikel PLGA-EEKBJ dosis 110 mg/kg BB efektif memperbaiki profil kolesterol danstruktur histologis jantung tikus model diabetes.

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“…Alkaloids, flavonoids and saponins are present as well as triterpenes and glycosides [79,88]. The leaf extract of M. excelsa is reported to be safe in rodents [79,89,90].…”

Section: Milicia Excelsa (Welw) CC Bergmentioning

confidence: 99%

Medicinal Plants Used as Galactagogues

Bekoe¹,

Kitcher²,

Gyima³

et al. 2019

Pharmacognosy - Medicinal Plants

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The recommended diet for human infants within the first 6 months of life is breast milk. No other natural or artificial formulation has been able to match up to this gold standard. Mothers who have attempted to pursue exclusive breastfeeding can, however, attest to numerous nutritional and non-nutritional challenges mainly resulting in insufficient milk production (hypogalactia) or the absence of milk production (agalactia). There are very few and officially recommended orthodox drugs to increase lactation. The most widely used galactagogues being chlorpromazine, sulpiride, metoclopramide and domperidone are associated with very high incidences of unpleasant side effects including their extra-pyramidal effects in both mother and infant. There is therefore a need to keep searching for more acceptable galactagogues. This section reviews current literature on medicinal plants used within the local Ghanaian community to enhance lactation. Various electronic databases such as PubMed, Science Direct, SciFinder and Google Scholar as well as published books on Ghanaian medicinal plants were searched. A total of 22 plants belonging to 13 families were reviewed with regards to their medicinal values, information on lactation and toxicity.

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Review of twelve West Africa medicinal plants: Active phytochemical combinations in direct biochemically wound healing process

Cited by 9 publications

References 50 publications

Analgesic effect of Sansevieria longiflora (Sim) water extract and xylocaine cream on surgical wound incision in rats

Analgesic effect of Sansevieria longiflora (Sim) water extract and xylocaine cream on surgical wound incision in rats

Perbaikan Profil Kolesterol dan HistologisJantung Tikus Model Diabetes dengan Nanopartikel Poly(Lactic-Co-Glycolic Acid) -Ekstrak Etanol Kulit Buah Jengkol

Medicinal Plants Used as Galactagogues

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