Review of zirconia-based biomimetic scaffolds for bone tissue engineering

Weng, Wenxian; Wu, Weiwei; Hou, Mengdie; Liu, Taotao; Wang, Tianlin; Yang, Haw

doi:10.1007/s10853-021-05824-2

Cited by 25 publications

(15 citation statements)

References 132 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Very recently, Weng et.al summarized the properties and construction of ZrO 2 and its composite materials [107]. Moreover, we have observed substantial development that has been lately accomplished in this theme.…”

Section: Hybrid Techniquesmentioning

confidence: 73%

Three-Dimensional Zirconia-Based Scaffolds for Load-Bearing Bone-Regeneration Applications: Prospects and Challenges

et al. 2021

View full text Add to dashboard Cite

The design of zirconia-based scaffolds using conventional techniques for bone-regeneration applications has been studied extensively. Similar to dental applications, the use of three-dimensional (3D) zirconia-based ceramics for bone tissue engineering (BTE) has recently attracted considerable attention because of their high mechanical strength and biocompatibility. However, techniques to fabricate zirconia-based scaffolds for bone regeneration are in a stage of infancy. Hence, the biological activities of zirconia-based ceramics for bone-regeneration applications have not been fully investigated, in contrast to the well-established calcium phosphate-based ceramics for bone-regeneration applications. This paper outlines recent research developments and challenges concerning numerous three-dimensional (3D) zirconia-based scaffolds and reviews the associated fundamental fabrication techniques, key 3D fabrication developments and practical encounters to identify the optimal 3D fabrication technique for obtaining 3D zirconia-based scaffolds suitable for real-world applications. This review mainly summarized the articles that focused on in vitro and in vivo studies along with the fundamental mechanical characterizations on the 3D zirconia-based scaffolds.

show abstract

Section: Hybrid Techniquesmentioning

confidence: 73%

Three-Dimensional Zirconia-Based Scaffolds for Load-Bearing Bone-Regeneration Applications: Prospects and Challenges

et al. 2021

View full text Add to dashboard Cite

show abstract

“…As well, both PCL–PLA‐3 and PCL–PLA‐5 showed almost equal metabolic activity, and increasing n‐ZrO 2 content from 3% to 5% did not significantly impact cell viability. Other researchers have also reported improvement in cell viability by adding n‐ZrO 2 within the system 18 . For instance, Chan et al 55 prepared PLLA nanocomposite scaffolds containing various oxide ceramics, including hafnium dioxide, titanium dioxide, silicon dioxide, and zirconium dioxide.…”

Section: Resultsmentioning

confidence: 99%

“…In regenerative medicine and tissue engineering fields, using nZrO 2 remarkably improved the hydrophilicity, biological, antibacterial activity, thermal, and mechanical properties of scaffolds and provided various functions according to the application. [15][16][17][18] For instance, n-ZrO 2 has shown promising results in bone 19 and cartilage 20 tissue engineering. Wang et al 17 The development of advanced materials by combining biodegradability and conductivity is a hot topic in tissue engineering and regenerative medicine due to their up-and-coming applications.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Conductive poly(ε‐caprolactone)/polylactic acid scaffolds for tissue engineering applications: Synergy effect of zirconium nanoparticles and polypyrrole

Jafari

Mirzaei

Shafiei

et al. 2022

Polymers for Advanced Techs

View full text Add to dashboard Cite

Biocompatible and electrically conductive porous scaffolds with a desirable hydrophilicity and degradation rate and suitable mechanical performance are highly favorable for tissue engineering and regenerative medicine applications. In this study, we fabricated three-dimensional (3D) porous bioscaffolds from poly(ε-caprolactone) and polylactic acid containing different concentrations of zirconia nanoparticles (n-ZrO 2 ) through freeze-drying technique. Afterward, the surface of the scaffolds was coated with an electrically conductive layer through in situ polymerization of polypyrrole (PPy) on the samples. Bioscaffolds exhibited a favorable range of mechanical properties and electrical conductivity, meeting the required mechanical performances and conductivity for a broad range of tissue engineering applications. Coating PPy on the scaffolds resulted in significantly higher hydrophilicity and faster biodegradation rate, as well as a noticeable enhancement on the in vitro cell attachment, proliferation, and viability. Our findings indicated that the simultaneous presence of n-ZrO 2 and PPy in the system presents a noticeable synergistic effect in overall properties and introduces the fabricated 3D porous scaffolds as promising candidates for tissue engineering and regenerative medicine applications.

show abstract

“…Monoclinic phase is an important factor to estimate the stability of YSZ ceramic materials. XRD is often used to detect the existence of m phase according to Garvie and Nicholson’s equation 34 , 35 : where is the area of the diffraction peak related to the (hkl) crystal plane.…”

Section: Resultsmentioning

confidence: 99%

Effect of thermal treatment at high temperature on phase stability and transformation of Yb2O3 and Y2O3 co-doped ZrO2 ceramics

Cao

Song

2022

Sci Rep

View full text Add to dashboard Cite

Y2O3 doped ZrO2 (YSZ) ceramic material is used to protect alloy components worked in high-temperature. But its phase transformation between tetragonal phase and monoclinic phase occurred at 1150 °C leads to YSZ invalid. Therefore, enhancing the phase stability of YSZ is necessary for meeting the demands of the development of thermal barrier coatings (TBC). In this study, X-ray diffraction and Raman spectra were used to explore the phase stability and phase transformation of Yb2O3 and Y2O3 co-doped ZrO2 (YbYSZ) ceramics after heat treatment at 1300 °C with different times. The stability of tetragonal phase is improved by tetragonality decreasing with Yb3+ doped. Simultaneously, the incorporation of Yb3+ leads to O–O coupling, which is beneficial for increasing the concentration of oxygen vacancies near the substituted ions, thereby improving the stability of the crystal. The 6.5YbYSZ ceramic has the best stability after heat treatment at 1300 °C for different times.

show abstract

Review of zirconia-based biomimetic scaffolds for bone tissue engineering

Cited by 25 publications

References 132 publications

Three-Dimensional Zirconia-Based Scaffolds for Load-Bearing Bone-Regeneration Applications: Prospects and Challenges

Three-Dimensional Zirconia-Based Scaffolds for Load-Bearing Bone-Regeneration Applications: Prospects and Challenges

Conductive poly(ε‐caprolactone)/polylactic acid scaffolds for tissue engineering applications: Synergy effect of zirconium nanoparticles and polypyrrole

Effect of thermal treatment at high temperature on phase stability and transformation of Yb2O3 and Y2O3 co-doped ZrO2 ceramics

Contact Info

Product

Resources

About