Review on Assessment of Response of Neo-Adjuvant Chemotherapy in Patients of Carcinoma Breast by High Frequency Ultrasound

Background: Breast cancer is the highly prevalent malignancy and is a major killer in women around world. In India, there is substantial statistically significant increase in breast cancer incidence patterns. Women from under developed areas(883000 cases) have a significantly higher no. of cases than those from developed areas (794,000) [1]. There are various risk factors associated with breast malignancy. A variety of bio-chemical markers have been tested to determine the malignancy, for the early detection of carcinoma of different origin. LDH is the easiest and cheapest to calculate of all of these indicators. Objectives: To study the clinical profile of patient with breast To study the prognostic significance of LDH as tumor marker in breast To compare post-operative LDH level in patient undergoing surgery for carcinoma breast v/s patient undergoing neoadjuvant chemotherapy. Compare variation in preoperative baselines LDH levels and post-operative LDH levels. Methodology: It is a prospective observational study done on patients with breast cancer. It will be conducted at Dept. of General Surgery , J.N.M.C and AVBRH, Sawangi (Meghe), Wardha. The study will be conducted on patients with Carcinoma Breast. Results: To be assessed after the study. Conclusion: Serum LDH is a good prognostic marker of breast cancer.

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“…al. reported on assessment of response of neo-adjuvant chemotherapy in patients of carcinoma breast by high frequency ultrasound [14]. Jaggi et.…”

Section: Discussionmentioning

confidence: 99%

Study of Clinical Profile of Carcinoma Breast and Prognostic Significance of Serum Lactate Dehydrogenase as Tumor Marker in Carcinoma Breast

Malhotra

Wagh

Yeola

2021

JPRI

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“…They concluded that spectral color doppler is a reliable technique in predicting malignancy of BI-RADS 3 breast masses. Few of the related studies on breast malignancies were reviewed [25][26][27][28].…”

Section: Discussionmentioning

confidence: 99%

Doppler Indıces Evaluatıon In Malıgnant Breast Lesıons: A Revıew

Jain

Phatak

Dhande

et al. 2021

JPRI

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The incidence of breast malignancy has displayed a rapid rise in recent times. It is one of the most common malignancies found in women. Women should be educated and made aware about self breast examination in order to detect malignancies at an early stage so that the prognosis can be improved. Breast pathologies can be classified into malignant and benign ones on the basis of signs and symptoms and by ultrasonography but can be confirmed on histopathology which remains the gold standard. Breast ultrasonography is the most common non ionizing radiological investigation used to assess breast lesions especially in women with dense or painful breasts. Breast carcinomas appear irregularly shaped hypoechoic lesions with non-circumscribed margins, but these features can rarely be manifested by benign lesions as well. Recent introduction of doppler ultrasound has led to an increase in the sensitivity of detecting breast carcinoma since most of the breast malignancies are hyper vascular and they show high resistivity index on spectral analysis. Angiogenesis in malignant lesions lead to formation of structurally abnormal and tortuous vessels with increased resistive index. Several studies on doppler analysis of breast malignancies have shown Doppler ultrasound to be a safe and effective modality showing acceptable diagnostic accuracy for non-invasive characterization of malignant breast lesions. Therefore, it can be employed as an alternative to histopathology in patients who present with breast lesions.

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“…A well prepared guidelines for carcinoma breast detection and management which are evidence based have been well developed and disseminated in several developed nations [12]. A number of studies on breast carcinoma were reported [13][14][15][16][17] 24] were reviewed. Breast imaging with ultrasonography or diagnostic mammography, followed by core needle biopsy forms a diagnostic basis for carcinoma breast.…”

Section: Discussionmentioning

confidence: 99%

Study of Clinical Profile and Management of LABC- our Experience

Nikhade

Rinait

Akulwar

et al. 2021

JPRI

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Introduction and Objective: Worldwide, breast carcinoma is among the most common carcinoma in females. It is commonly seen site-specific carcinoma in females. Due to lack of education, breast carcinoma patients present in later stages of the disease to healthcare facilities, especially in developing nations. Patients with Locally advanced carcinoma breast (LABC) are commonly seen in developing nations and its treatment multidisciplinary approach. This study is our experience of clinical profile and LABC in a rural setup. Methodology: This is a retrospective and prospective study done in the medical college. Data was taken from 72 cases that were operated on at the institute from July 2018 to June 2021 and diagnosed with LABC. Patients who had histological evidence of malignancy were undergone surgery and other treatment modalities like neoadjuvant chemotherapy, adjuvant chemoradiation, and hormonal therapy. Results: Seventy-two patients diagnosed with LABC over three years were included in the study. The mean age was 51 years. The tumor size was more than 5cm in 60 (83.3%) patients. Involvement of axilla was present in 62 (86.1%) patients. All patients were diagnosed with histopathology after core needle biopsy. Neoadjuvant chemotherapy was given to 62 (86.1%) patients. Most of the patients (65) were undergone MRM as surgery, while the remainder (7) were undergone breast conservation therapy. Very few patients had postoperative complications, but with limited follow-up until this study, 5 (6.9%) patients had a recurrence of their study. Conclusion: In developing nations high percentage of Locally advanced breast carcinoma at presentation result in poor prognosis, high rate of metastasis, and mortality. Awareness and education about breast health and multimodality treatment of LABC will have long-term effects to decrease morbidity and mortality and improve outcomes.

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Review on Assessment of Response of Neo-Adjuvant Chemotherapy in Patients of Carcinoma Breast by High Frequency Ultrasound

Cited by 9 publications

References 50 publications

Study of Clinical Profile of Carcinoma Breast and Prognostic Significance of Serum Lactate Dehydrogenase as Tumor Marker in Carcinoma Breast

Study of Clinical Profile of Carcinoma Breast and Prognostic Significance of Serum Lactate Dehydrogenase as Tumor Marker in Carcinoma Breast

Doppler Indıces Evaluatıon In Malıgnant Breast Lesıons: A Revıew

Study of Clinical Profile and Management of LABC- our Experience

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