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Background: Cancer is a biggest burden of modern society. Gastric cancer is the second leading cause of cancer death in the world. The objective of study was to study the clinico pathological features and management and outcome of gastric cancer patients admitted to hospital. Methodology: A prospective descriptive study was conducted in 50 diagnosed patients of gastric adenocarcinoma using pre-designed questionnaire collecting information on demographics, stage and site of tumor, clinical history, duration of stay etc. Results: There were 50 patients with male to female ratio 2.5: 1 with mean age of 62+/-7.89 SD. 88% patients had tumor at antrum region. 25 (50%) and 28 (56%) patients gave h/o smoking and alcohol consumption respectively with 23 (46%) had biopsy positive for H. pylori. Of the gastrectomies, 41 (82%) study subjects were managed by curative surgeries. The overall hospital stay in stage II gastric adenocarcinoma was 6-8 days and 7-8 days in stage III (p=0.16). Conclusion: systematic population screening program of upper gastrointestinal endoscopy should be established to detect early cases of gastric cancer show that treatment may be initiated early which has impact on survival for this dreaded diseases.

Introduction and Objective: Worldwide, breast carcinoma is among the most common carcinoma in females. It is commonly seen site-specific carcinoma in females. Due to lack of education, breast carcinoma patients present in later stages of the disease to healthcare facilities, especially in developing nations. Patients with Locally advanced carcinoma breast (LABC) are commonly seen in developing nations and its treatment multidisciplinary approach. This study is our experience of clinical profile and LABC in a rural setup. Methodology: This is a retrospective and prospective study done in the medical college. Data was taken from 72 cases that were operated on at the institute from July 2018 to June 2021 and diagnosed with LABC. Patients who had histological evidence of malignancy were undergone surgery and other treatment modalities like neoadjuvant chemotherapy, adjuvant chemoradiation, and hormonal therapy. Results: Seventy-two patients diagnosed with LABC over three years were included in the study. The mean age was 51 years. The tumor size was more than 5cm in 60 (83.3%) patients. Involvement of axilla was present in 62 (86.1%) patients. All patients were diagnosed with histopathology after core needle biopsy. Neoadjuvant chemotherapy was given to 62 (86.1%) patients. Most of the patients (65) were undergone MRM as surgery, while the remainder (7) were undergone breast conservation therapy. Very few patients had postoperative complications, but with limited follow-up until this study, 5 (6.9%) patients had a recurrence of their study. Conclusion: In developing nations high percentage of Locally advanced breast carcinoma at presentation result in poor prognosis, high rate of metastasis, and mortality. Awareness and education about breast health and multimodality treatment of LABC will have long-term effects to decrease morbidity and mortality and improve outcomes.

Cholelithiasis is very common problem affecting humans. Laparoscopic cholecystectomy (LC) has become gold standard for the management of symptomatic cholelithiasis [2]. Approximately 2% to 14% of patients may require conversion to open surgery for various factors and complications [2,4]. It would be very useful if there is established criteria to know the chances or risk of conversion to open surgery preoperatively. This study is to predict difficult laparoscopic cholecystectomy by clinical, pathological, and radiological assessment. Methodology: In this multi-center prospective study all patients require surgery in the form of cholecystectomy for reasons like acute and chronic cholecystitis. Sixty patients who underwent laparoscopic cholecystectomy between July 2020 and June 2021 met the inclusion criteria. Findings during surgery were divided into categories like easy, difficult, and very difficult laparoscopic cholecystectomy based on operative parameters like total time for surgery, injury to cystic duct or artery, spillage of stones of gallbladder, frozen Callot’s Triangle, and convert to open surgery. Results: Patients included in the study were divided into three groups, easy, difficult, and very difficult, in each parameter taken into account for surgery. All patients of the very difficult group were converted to open surgery eventually. Mean conversion rate in our study was 6.7%.

Amoebic liver abscess (ALA) is the commonest extra-intestinal manifestation of amoebic infection. Unfortunately, there is confusion among medical community regarding management of amoebic liver abscess. Aims: To assess outcome of patients with uncomplicated ALA treated using conservative approach. Methodology: Prospective, observational study was carried out over period of 2 year. Amoebic liver abscess was diagnosed on clinical, ultra sonographic, and serological features. All patients were treated with metronidazole. The indication for ultrasound guided aspiration of abscess was failure to improve clinically within 48 -72 hours Complications and outcome of patients were noted. Results: 80 (80%) patients were managed conservatively and 20 (20%) patients were managed by aspiration. 32% in 31-40 years of age group. 93% were male. We found the study participants who required intervention as a line of management had more deranged liver functions and that to found statistically significant. Conclusion:Conservative medical management of amoebic liver abscess is safe and effective.