Review on Biocompatibility of ZnO Nano Particles

Barman, Ananya

doi:10.1007/978-81-322-2256-9_32

Cited by 17 publications

(11 citation statements)

References 43 publications

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“…However, among various NPs, the ZnO NP, a semiconductor metal oxide, is extensively used in the medicinal industry and believed to be a biosafe, biocompatible, and non-toxic nanomaterial (Ali et al, 2018). Biocompatibility studies revealed no significant toxicity of ZnO NPs either in cell lines or during topical application for skin infection (Pati et al, 2014;Barman, 2015;Yusof et al, 2019). In addition to having excellent antimicrobial activity and preventing microbial biofilm deposition on implants, ZnO NPs also promoted proliferation of normal cells and angiogenesis (Memarzadeh et al, 2015;Oleshko et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…In addition to having excellent antimicrobial activity and preventing microbial biofilm deposition on implants, ZnO NPs also promoted proliferation of normal cells and angiogenesis (Memarzadeh et al, 2015;Oleshko et al, 2020). Hence, ZnO NPs were used for incorporation in implant and scaffold development (Pati et al, 2014;Barman, 2015;Yusof et al, 2019). Moreover, ZnO NPs displayed the potential for use as a supplement of Zn (essential micronutrient) in diet for regulation of innate and adaptive immune responses, enhancement of growth and development, prevention of local and systemic candidiasis, etc.…”

Section: Introductionmentioning

confidence: 99%

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Synergism of Zinc Oxide Quantum Dots with Antifungal Drugs: Potential Approach for Combination Therapy against Drug Resistant Candida albicans

Chand

Kumari

Mondal

et al. 2021

Front. Nanotechnol.

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Candidiasis caused by Candida albicans is one of the most common microbial infections. Azoles, polyenes, allylamines, and echinocandins are classes of antifungals used for treating Candida infections. Standard drug doses often become ineffective due to the emergence of multidrug resistance (MDR). This leads to the use of higher drug doses for prolonged duration, resulting in severe toxicity (nephrotoxicity and liver damage) in humans. However, combination therapy using very low concentrations of two or more antifungal agents together, can lower such toxicity and limit evolution of drug resistance. Herein, 4–6 nm zinc oxide quantum dots (ZnO QDs) were synthesized and their in vitro antifungal activities were assessed against drug-susceptible (G1, F1, and GU4) and resistant (G5, F5, and GU5) isolates of C. albicans. In broth microdilution assay, ZnO QDs exhibited dose dependent growth inhibition between 0 – 200 µg/ml and almost 90% growth was inhibited in all Candida strains at 200 µg/ml of ZnO QDs. Synergy between ZnO QDs and antifungal drugs at sub-inhibitory concentrations of each was assessed by checkerboard analysis and expressed in terms of the fractional inhibitory concentration (FIC) index. ZnO QDs were used with two different classes of antifungals (azoles and polyenes) against Candida isolates: combination 1 (with fluconazole); combination 2 (with ketoconazole); combination 3 (with amphotericin B), and combination 4 (with nystatin). Results demonstrated that the potency of combinations of ZnO QDs with antifungal drugs even at very low concentrations of each was higher than their individual activities against the fungal isolates. The FIC index was found to be less than 0.5 for all combinations in the checkerboard assay, which confirmed synergism between sub-inhibitory concentrations of ZnO QDs (25 µg/ml) and individual antifungal drugs. Synergism was further confirmed by spot assay where cell viabilities of Candida strains were significantly reduced in all combinations, which was clearly evident from the disappearance of fungal cells on agar plates containing antifungal combinations. For safer clinical use, the in vitro cytotoxic activity of ZnO QDs was assessed against HeLa cell line and it was found that ZnO QDs were non-toxic at 25 µg/ml. Results suggested that the combination of ZnO QDs with drugs potentiate antimicrobial activity through multitargeted action. ZnO QDs could therefore offer a versatile alternative in combination therapy against MDR fungal pathogens, wherein lowering drug concentrations could reduce toxicity and their multitargeted action could limit evolution of fungal drug resistance.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synergism of Zinc Oxide Quantum Dots with Antifungal Drugs: Potential Approach for Combination Therapy against Drug Resistant Candida albicans

Chand

Kumari

Mondal

et al. 2021

Front. Nanotechnol.

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“…On the other hand, highly doped ZnO nanowires are considered as promising for transparent electronics thanks to its good light transmittance, metalliclike conductivity, and good adhesion to the flexible substrates 16 . The other advantages of ZnO nanowires also include chemical inertness and biocompatibility 17 .…”

Section: Introductionmentioning

confidence: 99%

Evidence of Piezoelectric Potential and Screening Effect in Single Highly Doped ZnO:Ga and ZnO:Al Nanowires by Advanced Scanning Probe Microscopy

et al. 2021

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A complete study based on advanced atomic force microscopy (AFM) electrical mode called scanning spreading resistance microscopy (SSRM) is carried out on a series of samples of zinc oxide (ZnO) nanowires grown by chemical bath deposition (CBD) with different doping concentrations using gallium (Ga). The concentration of free charge carriers determined through SSRM signal calibration with a specific molecular beam epitaxy (MBE) grown multilayer structure with variation in each layer of electrically active Ga doping ranges from 1×10 17 to 7×10 20 at/cm 3 . The concentration of free charge carriers found changes in every nanowire sample with a different ratio of the doping precursor. It increases from 3×10 18 at/cm 3 in non-intentionally doped (NiD) nanowires to 7.6×10 19 at/cm 3 in samples grown with a doping precursor concentration [Ga(NO3)3]/[Zn(NO3)2] of more than 2%, which makes it possible to gradually dope the nanowires with more accurate regulation of the precursor concentration. A similar electrical activity for aluminum (Al) doped nanowires is found. Piezoresponse force microscopy (PFM) in dualfrequency resonance tracking (DFRT) mode reveals a stable piezoelectric activity of highly doped nanowires that is presumably attributed to the increased surface trap density causing a Fermi level pinning when ZnO nanowires are grown at a high pH value favorable for the intentional doping.It also shows the degradation of piezoelectric properties caused by the "screening effect," which directly correlates with the increase of free charge carrier concentration in nanowires. PFM in DFRT mode is eventually proposed as an original direct method for analyzing the electrical properties of a single piezoelectric nanowire.

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“…ZnO nanoparticles are non-toxic, photooxidant and photocatalyst, and have skin-friendly properties. Besides, due to the antimicrobial properties of materials in nanostructure nature, therefore, in case of MOF production, they will find not only desirable properties, but also considerable physicochemical properties, which can be used in various fields [23,24].Zhang and coworkers have synthesized two dimensional pillar-layered Zn MOF by solvothermally which can selectively adsorb carbon di oxide over nitrogen and methane [25].…”

Section: Introductionmentioning

confidence: 99%

A novel synthesis of new antibacterial nanostructures based on Zn-MOF compound: design, characterization and a high performance application

Akbarzadeh

Motaghi

Chauhan³

et al. 2020

Heliyon

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In this study, the novel zinc metal-organic frameworks (MOF) nanostructure has been employed, which was developed using an affordable, environmental friendly, efficient and fast method of ultrasound-assisted reverse micelle (UARM). These nanostructures were identified with various techniques such as FT-IR, XRD, BET, SEM, TG-DSC, TEM and EDS. It was found that the Zn-MOF samples have favorable physicochemical properties. The impact of experimental parameters of the UARM method is effective on the resulting properties, such as high surface area of the products that increases the interactions between the Zn-MOF nanostructure and bacteria.Their antibacterial activities were investigated using diffusion methods in agar and also with dilutions of Zn-MOF samples. Antibiotics (tetracycline and ampicillin) and their anti-biofilm effects were evaluated using microplate method. Obtained results revealed that the Zn-MOF nanostructures have high antibacterial properties which, could be due to the nature of the applied Zn-MOF as well as the optimization process. The Zn-MOF nanostructures could be a novel antibacterial material as biocatalyst processes.

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Review on Biocompatibility of ZnO Nano Particles

Cited by 17 publications

References 43 publications

Synergism of Zinc Oxide Quantum Dots with Antifungal Drugs: Potential Approach for Combination Therapy against Drug Resistant Candida albicans

Synergism of Zinc Oxide Quantum Dots with Antifungal Drugs: Potential Approach for Combination Therapy against Drug Resistant Candida albicans

Evidence of Piezoelectric Potential and Screening Effect in Single Highly Doped ZnO:Ga and ZnO:Al Nanowires by Advanced Scanning Probe Microscopy

A novel synthesis of new antibacterial nanostructures based on Zn-MOF compound: design, characterization and a high performance application

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