Review on microfluidic paper-based analytical devices towards commercialisation

Akyazi, Tuğçe; Basabe‐Desmonts, Lourdes; Benito‐Lopez, Fernando

doi:10.1016/j.aca.2017.11.010

Cited by 423 publications

(235 citation statements)

References 289 publications

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“…Electrochemical paper‐based microfluidic devices is a growing trend, shown to be successful for the detection of DNA, metals,, immunoassays,, neurotransmitters, as well as for biological sensing and environmental monitoring ,,. The electrochemical response in paper is fast with high sensitivity and selectivity …”

Section: Introductionmentioning

confidence: 99%

“…In 2007, the Whitesides group introduced the first paper‐based analytical devices (PADs) for use in biomedical research and clinical diagnostics . Researchers expanded upon this concept, showing that microfluidic paper‐based devices can be used to assess water quality, be used as detection devices with fluorescence, chemiluminescence, and electrochemiluminescense . Electrochemical PADs (ePADs), emerged by screen‐printing electrodes on paper for the detection of glucose, lactate, and uric acid in biological samples ,.…”

Section: Introductionmentioning

confidence: 99%

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Spectro‐Electrochemical Microfluidic Platform for Monitoring Multi‐Step Cascade Reactions

et al. 2018

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Benefits of utilizing cascade reactions for chemical synthesis include minimizing waste and decreasing experimentation times. However, these complex systems lack an efficient screening platform for evaluating their progression. A paper‐based microfluidic platform was developed to monitor cascade systems without the need for off‐line product verification. Two types of paper‐based platforms were fabricated to facilitate this study: electrochemical and spectro‐electrochemical. Electrochemical platforms were integrated with stencil‐printed electrodes and used to perform electrochemical alcohol oxidation reactions with two derivatives of the organocatalyst TEMPO (TEMPO=2,2,6,6‐tetramethylpiperidinyl‐N‐oxyl). The catalyst 4‐amino‐TEMPO (TEMPO‐NH2) was used as a model catalyst that was studied not immobilized and immobilized (pyrene‐amido‐TEMPO) on electrochemical platforms. These platforms were designed to provide quasi‐stationary flow allowing constant electrochemical data collection as catalytic reactions proceeded. TEMPO‐NH2 and pyrene‐amido‐TEMPO were evaluated for the partial oxidation of glycerol and its intermediates. In comparison to TEMPO‐NH2, the pyrene‐amido‐TEMPO catalyst produced higher current outputs. Spectro‐electrochemical platforms were integrated with stencil‐printed electrodes, and a surface enhanced Raman spectroscopy (SERS) detection zone. The spectro‐electrochemical platforms allowed for catalytic conversions at the electrodes and subsequent delivery of catalytically transformed analytes to a SERS detection zone for product analysis. This platform was demonstrated for pyrene‐amido‐TEMPO and was shown to convert glycerol to mesoxalic acid. The experimental procedures for making components of the spectro‐electrochemical device were described and include: preparation of the paper‐based platform, construction of stencil‐printed electrodes, and fabrication of SERS detection zones. These platforms provide an approach to analyzing multi‐step cascade chemical reactions.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Spectro‐Electrochemical Microfluidic Platform for Monitoring Multi‐Step Cascade Reactions

et al. 2018

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“…μPADs introduce an innovative platform technology for fluid handling and analysis with wide range of applications including diagnostic biosensing, food safety and environmental monitoring (Tomazelli Coltro et al, 2014;Fernandes et al, 2017;Ghaderinezhad et al, 2017;K.etisen et al, 2013;Ma et al, 2018;Qi et al, 2017;Weng et al, 2018;Weng and Neethirajan, 2018a, 2017Xia et al, 2016;, due to the advantages of portability, simplicity, economic affordability and minimal sample consumption (Akyazi et al, 2017;Cate et al, 2014;Gong and Sinton, 2017;He et al, 2016;Hu et al, 2014;Yamada et al, 2017). However, the low mechanical strength and surface tension as well as the requirement of hydrophobic barriers still limit their practical applications in making microfluidic analytical devices (Agustini et al, 2016;Akyazi et al, 2017;Dou et al, 2015;.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in thread-based microfluidics for diagnostic applications

Weng

Kang

Guo

et al. 2019

Biosensors and Bioelectronics

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Keywords:Thread-based microfluidics Point-of-care Cotton Colorimetric Electrochemical A B S T R A C T Over the past decades, researchers have been seeking attractive substrate materials to keep microfluidics improving to outbalance the drawbacks and issues. Cellulose substrates, including thread, paper and hydrogels are alternatives due to their distinct structural and mechanical properties for a number of applications. Thread have gained considerable attention and become promising powerful tool due to its advantages over paper-based systems thus finds numerous applications in the development of diagnostic systems, smart bandages and tissue engineering. To the best of our knowledge, no comprehensive review articles on the topic of thread-based microfluidics have been published and it is of significance for many scientific communities working on Microfluidics, Biosensors and Lab-on-Chip. This review gives an overview of the advances of thread-based microfluidic diagnostic devices in a variety of applications. It begins with an overall introduction of the fabrication followed by an in-depth review on the detection techniques in such devices and various applications with respect to effort and performance to date. A few perspective directions of thread-based microfluidics in its development are also discussed. Thread-based microfluidics are still at an early development stage and further improvements in terms of fabrication, analytical strategies, and function to become low-cost, low-volume and easy-to-use pointof-care (POC) diagnostic devices that can be adapted or commercialized for real world applications.

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“…Microfluidics may be considered as a multidisciplinary science that has been used in several fields and applications such as chemistry , microelectronics , molecular and clinical diagnostics , environmental monitoring , food control and engineering , and detection and screening of residues of explosives . It is already a well‐established research topic and has also attracted attention of industry due to novel methods and products developed using this technology .…”

Section: Introductionmentioning

confidence: 99%

Rapid and inexpensive method for the simple fabrication of PDMS‐based electrochemical sensors for detection in microfluidic devices

2019

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The fabrication of PDMS microfluidic structures through soft lithography is widely reported. While this well‐established method gives high precision microstructures and has been successfully used for many researchers, it often requires sophisticated instrumentation and expensive materials such as clean room facilities and photoresists. Thus, we present here a simple protocol that allows the rapid molding of simple linear microchannels in PDMS substrates aiming microfluidics‐based applications. It might serve as an alternative to researchers that do not have access to sophisticated facilities such as clean rooms. The method developed here consists on the use of pencil graphite leads as template for the molding of PDMS channels. It yields structures that can be used for several applications, such as housing support for electrochemical sensors or channels for flow devices. Here, the microdevices produced through this protocol were employed for the accommodation of carbon black paste, which was utilized for the first time as amperometric sensor in microchip electrophoresis. This platform was successfully used for the separation and detection of model analytes. Ascorbic acid and iodide were separated within 45 s with peak resolution of 1.2 and sensitivities of 198 and 492 pA/μM, respectively. The background noise was ca. 84 pA. The analytical usefulness of the system developed was successfully tested through the quantification of iodide in commercial pharmaceutical formulations. It demonstrates good efficiency of the microfabrication protocol developed and enables its use for the easy and rapid prototyping of PDMS structures over a low fabrication cost.

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Review on microfluidic paper-based analytical devices towards commercialisation

Cited by 423 publications

References 289 publications

Spectro‐Electrochemical Microfluidic Platform for Monitoring Multi‐Step Cascade Reactions

Spectro‐Electrochemical Microfluidic Platform for Monitoring Multi‐Step Cascade Reactions

Recent advances in thread-based microfluidics for diagnostic applications

Rapid and inexpensive method for the simple fabrication of PDMS‐based electrochemical sensors for detection in microfluidic devices

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