Review on Microspheres as Drug Carriers for Controlled Drug Delivery

Abstract

Microspheres are organic or inorganic spherical particles with a diameter of 1–1000 μm. These materials can encapsulate drugs or bioactive molecules and release them in a controlled way. Biodegradable polymers are frequently used for the development of microsphere matrixes such as polylactic acid and copolymer of lactic acid and glycolic acid. Apart from them, there is an extensive range of microspheres prepared from albumin, albumin dextran sulfate, and fibrinogen. Administration of medication via micro particulate systems is advantageous because microspheres can be ingested or injected; they can be tailored for desired release profiles and used for site-specific delivery of drugs and in some cases can even provide organ-targeted release. Microspheres in drug delivery are used for targeted as well as prolonged drug release in the diseased area. It also protects the unstable or pH-sensitive drugs before and after the administration. In this review we have discussed about advantages, disadvantages, methods of preparations and evaluation and types of microspheres. Keywords: Microsphere, Biodegradable polymers, Polymer Microsphere, Drug Release

Formulation and Evaluation of Sustained Release Solid Dispersed Nifedipine Microcapsules

“…The type of solid dispersion formed depends on both the carrier-drug combination and the method of manufacture 10 . Hydrophilic polymers like polyethylene glycols (PEG) [11][12][13] . Polyvinyl pyrrolidone (PVP) 14,15 and hydroxyl propyl methyl cellulose (HPMC) 16 are among the popular carriers commonly used to prepare solid dispersions.…”