Review on recent and advanced applications of monoliths and related porous polymer gels in micro-fluidic devices

Fast Fabrication Process of Microfluidic Devices Based on Cyclic Olefin Copolymer

“…Since the first fabrication of a polymer monolithic column inside a microfluidic channel [28], monolithic materials have been widely used in microfluidic platforms as separation columns, electrospray emitters, micro-valves, microreactors, and even micro-mixers [24]. UV-initiated polymerization of porous polymer monoliths has actually become a rather popular approach for integration of monoliths within microchannels.…”

“…In order to promote the covalent attachment of the monolithic structure to the channel walls, those were grafted with a thin layer of BMA polymer following a two-step procedure described elsewhere [24].…”

Immunodiagnostics and immunosensor design (IUPAC Technical Report)

“…These materials have been engineered to meet key criteria such as low autofluorescence, ease of fabrication, and manipulation. Importantly for microfluidics development, they also have excellent mouldability and good machinability to form complex microfluidic features such as channels [106,107], valves [108], and other features enabling samples to be preprocessed with relative ease: dilution or concentration in an appropriate buffered solution, filtration, purification, and the interaction with other bulk or surface-confined reagents.…”

Current Developments and Future Trends in Solid-phase Microextraction Techniques for Pharmaceutical and Biomedical Analyses

“…This new device promises a reduced analysis time and reagent consumption, low cost, short reaction time, the ability to integrate multiple functions onto a single device, easy automation and the potential for high-throughput analysis. [139][140][141][142] The chip-based microfluidic concept has greatly promoted the use of nanotechnology in laboratories and hospitals. 140 Many microfluidic systems have been developed to handle multiple procedures for miniaturized analysis, including nucleic acid purification, polymerase chain reaction (PCR), and electrophoretic separation.…”

“…These chip-based microfluidic systems can be widely employed for the purification and enrichment of biological molecules, including DNA, proteins, and peptides, to determine metabolic profiles and genetic transformation. [139][140][141][142][143][144][145][146][147][148] Recently, a microfluidic blood-sampling device using a double-layer PDMS chip was developed for automated collection of nL-size blood samples from mice, and applied to in vivo quantitative small-animal PET analysis. 145 The challenges in this technology are the design of the chip and the incorporation of proper materials for diverse purposes.…”