Review on the Bioactive Peptides from Marine Sources: Indication for Health Effects

Ghanbari, Raheleh

doi:10.1007/s10989-018-9766-x

Cited by 27 publications

(14 citation statements)

References 107 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ROS can also be suppressed by metal binding proteins, endogenous and exogenous antioxidants (Aitken, 2017a; MacLeod, 1943a; Sobhani et al, 2015b). H. parva coelom extract contains vitamins, co‐enzymes as well as superoxide dismutase, glutathione reductase and catalase (Ghanbari, 2018). Hence, it seems that unlike former studies that inhibited only one pathway, H. parva extract could be able to restrain action on all three pathways.…”

Section: Discussionmentioning

confidence: 99%

Novel additive for sperm cryopreservation media: Holotheria parva coelomic cavity extract protects human spermatozoa against oxidative stress—A pilot study

Khashavi¹,

Homaei

Koohnavard

et al. 2020

Andrologia

View full text Add to dashboard Cite

Cryopreservation is the most effective method for preserving semen for a long period of time. However, during the freeze–thaw process, production of reactive oxygen species (ROS) leads to a steep reduction in sperm fertility indices. In this study, we tested the effects of the extract of the coelomic cavity of five Holotheria parva, a marine organism rich in antioxidants, for its ROS‐scavenging activity and cryoprotective effects on oxidative stress. Using a total of 50 semen samples, our results demonstrated that doses of 250 and 500 µg/ml of H. parva coelomic cavity extract significantly increased sperm vitality as compared to the control (p < .05). The addition of 250 µg/ml of the extract exerted a significant positive effect on sperm motility. Moreover, sperm DNA damage and ROS production were significantly reduced at extract concentrations of 250 and 500 µg/ml (p < .05). To the best of our knowledge, the results of this study represent the first demonstration of the possibility of improving sperm parameters and reducing ROS production and DNA damage by supplementing sperm freezing media with H. parva coelomic extract. Our results suggested that H. parva coelomic extract could be useful for improving the fertilising ability of frozen‐thawed human semen.

show abstract

Section: Discussionmentioning

confidence: 99%

Novel additive for sperm cryopreservation media: Holotheria parva coelomic cavity extract protects human spermatozoa against oxidative stress—A pilot study

Khashavi¹,

Homaei

Koohnavard

et al. 2020

Andrologia

View full text Add to dashboard Cite

show abstract

“…Studies of the BPs found in proteins derived from marine sources have revealed a number of useful biological qualities, with antioxidative, antidiabetic and hypolipidemic properties reported alongside the inhibition of angiotensin-converting enzymes (ACE), and signs of immunomodulatory activity. 8,9 The spotted babylon snail, which is the subject of this study, is identied as Babylonia areolata Link, 1807, and is classied under the phylum Mollusca, class Neogastropoda, order Neogastropoda, and family Buccinidae. There are more than 5000 members of the order Neogastropoda, the vast majority of which comprise marine benthic species and carnivores.…”

Section: Introductionmentioning

confidence: 99%

The antioxidant potential of peptides obtained from the spotted babylon snail (Babylonia areolata) in treating human colon adenocarcinoma (Caco-2) cells

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Likewise, peptide rich egg hydrolysates reduce AT1R expression as well ( Jahandideh et al, 2016 ). Multiple peptides from other sources like meat ( Bhat et al, 2017 ), marine organisms ( Ghanbari, 2019 ), and plants ( Lee and Hur, 2017 ) have been reported to modulate the ACE/AT1R axis. Their ability to control ACE and AT1R expression possibly depends on the presence of positively charged amino acids along with hydrophobic tryptophan, that can bind to Zn 2+ at the enzyme active site, controlling its expression ( Liao et al, 2018 ).…”

Section: Peptides: Where Do They Fit?mentioning

confidence: 99%

Translating bioactive peptides for COVID-19 therapy

Bhullar

Drews

2021

European Journal of Pharmacology

View full text Add to dashboard Cite

COVID-19 (Coronavirus disease 2019) is a global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a positive-sense RNA virus. This virus has emerged as a threat to global health, social stability, and the global economy. This pandemic continues to cause rampant mortality worldwide with the dire urgency to develop novel therapeutic agents. To meet this task, this article discusses advances in the research and potential application of bioactive peptides for possible mitigation of infection by SARS-CoV-2. Growing insight into the molecular biology of SARS-CoV-2 has revealed potential druggable targets for bioactive peptides. Bioactive peptides with unique amino acid sequences can mitigate such targets including, type II transmembrane serine proteases (TMPRSS2) inhibition, furin cleavage, and renin-angiotensin-aldosterone system (RAAS) members. Based on current evidence and structure-function analysis, multiple bioactive peptides present potency to neutralize the virus. To date, no SARS-CoV-2-explicit drug has been reported, but we here introduce bioactive peptides in the perspective of their potential activity against SARS-CoV-2 infection.

show abstract

Review on the Bioactive Peptides from Marine Sources: Indication for Health Effects

Cited by 27 publications

References 107 publications

Novel additive for sperm cryopreservation media: Holotheria parva coelomic cavity extract protects human spermatozoa against oxidative stress—A pilot study

Novel additive for sperm cryopreservation media: Holotheria parva coelomic cavity extract protects human spermatozoa against oxidative stress—A pilot study

The antioxidant potential of peptides obtained from the spotted babylon snail (Babylonia areolata) in treating human colon adenocarcinoma (Caco-2) cells

Translating bioactive peptides for COVID-19 therapy

Contact Info

Product

Resources

About