Review on the biomedical and sensing applications of nanomaterial-incorporated hydrogels

Kailasa, Suresh Kumar; Joshi, Dharaben J.; Kateshiya, Mehul R.; Koduru, Janardhan Reddy; Malek, Naved I.

doi:10.1016/j.mtchem.2021.100746

Cited by 60 publications

(42 citation statements)

References 181 publications

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“…Hydrogels are well-known soft materials, three-dimensional designed polymeric networks that have the capability to retain a large amount of water without losing their structural integrity [ 1 ]. Holding a variety of adaptable chemical, physical, and biological properties, hydrogels have been extensively studied as versatile materials for specific applications [ 1 , 2 , 3 ]. A biocompatible, transparent, malleable, bioinert polymer, commonly used as a hydrogel in pharmaceutical applications is poly(vinyl-alcohol) (PVA) [ 4 , 5 , 6 ] ( Figure 1 ).…”

Section: Introductionmentioning

confidence: 99%

Tunable Properties via Composition Modulations of Poly(vinyl alcohol)/Xanthan Gum/Oxalic Acid Hydrogels

Enache

Serbezeanu²,

Vlad‐Bubulac³

et al. 2022

Materials

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The design of hydrogel networks with tuned properties is essential for new innovative biomedical materials. Herein, poly(vinyl alcohol) and xanthan gum were used to develop hydrogels by the freeze/thaw cycles method in the presence of oxalic acid as a crosslinker. The structure and morphology of the obtained hydrogels were investigated by means of scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, and swelling behavior. The SEM analysis revealed that the surface morphology was mostly affected by the blending ratio between the two components, namely, poly(vinyl alcohol) and xanthan gum. From the swelling study, it was observed that the presence of oxalic acid influenced the hydrophilicity of blends. The hydrogels based on poly(vinyl alcohol) without xanthan gum led to structures with a smaller pore diameter, a lower swelling degree in pH 7.4 buffer solution, and a higher elastic modulus. The antimicrobial activity of the prepared hydrogels was tested and the results showed that the hydrogels conferred antibacterial activity against Gram positive bacteria (Staphylococcus aureus 25923 ATCC) and Gram negative bacteria (Escherichia coli 25922 ATCC).

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Section: Introductionmentioning

confidence: 99%

Tunable Properties via Composition Modulations of Poly(vinyl alcohol)/Xanthan Gum/Oxalic Acid Hydrogels

Enache

Serbezeanu²,

Vlad‐Bubulac³

et al. 2022

Materials

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“…It may be due to the optimized degree of cross-linking that tailored physicochemical properties of the composite hydrogels that interact with pathogens differently. The role of GO cannot be denied; the sharp edges of GO may rupture the bacterial membrane to hinder its activity and replication ( Liang et al, 2021 ; Duan et al, 2022 ; Kailasa et al, 2022 ). The polymeric part of the composite hydrogel may interact with the bacterial membrane due to different functional groups and transfer its electrostatic charge.…”

Section: Resultsmentioning

confidence: 99%

Multifunctional Arabinoxylan-functionalized-Graphene Oxide Based Composite Hydrogel for Skin Tissue Engineering

Khan

Razak

Hassan

et al. 2022

Front. Bioeng. Biotechnol.

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Wound healing is an important physiological process involving a series of cellular and molecular developments. A multifunctional hydrogel that prevents infection and promotes wound healing has great significance for wound healing applications in biomedical engineering. We have functionalized arabinoxylan and graphene oxide (GO) using the hydrothermal method, through cross-linking GO-arabinoxylan and polyvinyl alcohol (PVA) with tetraethyl orthosilicate (TEOS) to get multifunctional composite hydrogels. These composite hydrogels were characterized by FTIR, SEM, water contact angle, and mechanical testing to determine structural, morphological, wetting, and mechanical behavior, respectively. Swelling and biodegradation were also conducted in different media. The enhanced antibacterial activities were observed against different bacterial strains (E. coli, S. aureus, and P. aeruginosa); anticancer activities and biocompatibility assays were found effective against U-87 and MC3T3-E1 cell lines due to the synergic effect of hydrogels. In vivo activities were conducted using a mouse full-thickness skin model, and accelerated wound healing was found without any major inflammation within 7 days with improved vascularization. From the results, these composite hydrogels might be potential wound dressing materials for biomedical applications.

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“…Starting from nanomaterial-incorporated hydrogels, Kailasa et al reviewed the synthesis methods of nanomaterial-integrated hydrogels, and elaborated their applications in biomedical sciences and in sensing of various target analytes. 44 Taking hydrogel adhesives as a starting point, Liu et al reviewed various hydrogel adhesives in the last decade, from design strategy to final application. 45 In addition, the review work by Janarthanan et al focused on the tissue engineering applications of hydrogels composed of metal ions such as Fe 3+ and Zn 2+ .…”

Section: Introductionmentioning

confidence: 99%

A review of recent advances in metal ion hydrogels: mechanism, properties and their biological applications

et al. 2022

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Review on the biomedical and sensing applications of nanomaterial-incorporated hydrogels

Cited by 60 publications

References 181 publications

Tunable Properties via Composition Modulations of Poly(vinyl alcohol)/Xanthan Gum/Oxalic Acid Hydrogels

Tunable Properties via Composition Modulations of Poly(vinyl alcohol)/Xanthan Gum/Oxalic Acid Hydrogels

Multifunctional Arabinoxylan-functionalized-Graphene Oxide Based Composite Hydrogel for Skin Tissue Engineering

A review of recent advances in metal ion hydrogels: mechanism, properties and their biological applications

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