Review on the role of Nanotechnology in Dentistry and Medicine

Sriram, Kadambari; Vishnupriya,; Gayathri, R

doi:10.5958/0974-360x.2016.00236.5

Cited by 8 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nanodentistry deals with diagnosing, treating, preventing dental diseases and improving oral health by using nanomaterials. Synthesis of biomaterials incorporated with nanoparticles is the latest research being undertaken with coverage of nano-related articles and patent applications (Sriram et al, 2016). Nanodentistry is based on the four novel approaches, which include topdown approach, bottom-down approach, functional approach and biomimetic approach (Jimbo et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Awareness of Use of Implant Coated with Nanoparticles with Antimicrobial Properties

Somasundaram

et al. 2020

ijrps

View full text Add to dashboard Cite

Nanoparticles are nowadays widely used in dentistry. They have an essential role in the prevention diagnosis and treatment of the patients. There are different types of novel approaches in the use of nanoparticles in dentistry. Introduction of nanorobots has wider benefits and has consequently led to other major uses of nanoparticles in different aspects of dentistry. Nanomaterials have further been used in delivering oral fluid or drugs, preventing and curing some oral disease and maintaining oral health care up to a great extent. The objective was to review their use in nanocomposites, implant coatings, its antimicrobial activity against cariogenic pathogens, periodontal biofilm, fungal pathogens and endodontic bacteria and other applications such as treatment of oral cancer and local anaesthesia. This survey consisted of 200 participants, and the structured questionnaire was circulated through online access. A set of 15 questions about the basic idea, knowledge and awareness about the implant coated with nanoparticles was prepared and circulated, and the results were analyzed. Development of modified nanoparticles is surely going to help in our practice. Therefore it is essential to create awareness about the implant coated with nanoparticles with antimicrobial activity. This article summarises the benefits of using implants coated with nanoparticles over the conventional implants and its awareness among the practitioners.

show abstract

Section: Introductionmentioning

confidence: 99%

Awareness of Use of Implant Coated with Nanoparticles with Antimicrobial Properties

Somasundaram

et al. 2020

ijrps

View full text Add to dashboard Cite

show abstract

“…Hydroxyapatite is widely used in medicine for artificial bone and to fill the osteoporosis bone. Despite its biocompatible, non-toxic, and osteoconductive characteristics, HA shows a limitation in the bone repair process as it has higher crystallinity than human bone apatite 14,15 . According to previous studies, the addition of carbonate elements to hydroxyapatite could improve its characteristics, such as increasing the solubility, decreasing the crystallinity, and changing the morphology of the crystal 16 .…”

mentioning

confidence: 99%

The Characteristics and Potency of Limestone-based carbonate hydroxyapatite to Viability and Proliferation of Human Umbilical Cord Mesenchymal Stem Cell

Rianti

Wahyudi²,

Damayanti³

et al. 2022

RJPT

View full text Add to dashboard Cite

Background: Limestone primarily consists of CaCO3 (calcium carbonate), which have a similarity to one of human bone component, hydroxyapatite (HA), an element of apatite group (Ca10(PO4)6(OH)2). There were several setbacks in the use of artificial hydroxyapatite in the bone repair process; one of them was its relatively higher crystallinity level compared to those of human bone apatite. The addition of carbonate element to hydroxyapatite could improve its characteristics, such as increasing the solubility, decreasing the crystallinity, and changing the morphology of the crystal. That caused carbonate hydroxyapatite is preferable to help in the bone repair process. Aims: This study aimed to find the effect of limestone-based CHA on viability and proliferation of hUMSCs, thus discovering the potential of CHA as a bone graft biomaterial candidate derived from limestone. Methods: This study used FTIR, EDX, and XRD assays to CHA powder sample derived from limestone found in Padalarang and Cirebon extracted by BBK. Two grams of the sample were placed in the sample holder and examined by computer software. EDX assay was conducted three times in three different points, and the means were recorded. In the XRD assay, a carbon tip was put to the sample holder to allow sample attachment. The recorded data was compared to JCPDS data. Toxicity and proliferation examination of CHA were conducted through MTT assay in human umbilical cord mesenchymal stem cell (hUCMSC) cell lines with four different doses: 50µg/ml, 25µg/ml, 12,5µg/ml, and 6,25µg/ml. Results: Limestone-based CA has hydroxyl (OH-), phosphate (PO42-), and carbonate (CO32-) functional groups. It has crystal particle formation and consists of O, Ca, and P elements. The result of the MTT assay showed limestone-based CHA is not toxic in all concentrations and has the proliferative ability. There were significant differences between the control and treatment groups. Conclusion: CHA has OH-, PO42-, and CO32- function group. It has crystal particle formation and O, Ca, and P elements as its composition, with a Ca/P ratio of 1,67. It shows no toxicity to hUCMSC in all doses and has the ability to stimulate hUCMSC proliferation.

show abstract

Enhanced Antibacterial Effect of Titanium Dioxide Nanoparticles Mediated Grape Seed Extract on Oral Pathogens - Streptococcus mutans and Lactobacillus

Ramya¹,

Rajasekar²

2021

jemds

View full text Add to dashboard Cite

BACKGROUND Streptococcus mutans is the primary pathogen responsible for initiating dental caries and decay. Lactobacilli present in caries lesions is a major contributor to caries progression. Titanium dioxide nanoparticles have been found to have a large spectrum of activity against microorganisms. The grape seed extract has been shown to have inhibitory effects against several clinically important microbes. This study was conducted to assess the enhanced antibacterial effect of titanium dioxide nanoparticles mediated grape seed extract against oral pathogens, S. mutans and lactobacillus. METHODS This experimental study was done by preparing the grape seed extract, synthesising titanium dioxide (TiO2) nanoparticles, preparing the nanoparticles powder, and then evaluating the antibacterial activity of nanoparticles against lactobacillus species and Streptococcus mutans. RESULTS The peak found in the spectroscopy indicates the formation of titanium dioxide nanoparticles. The zone of inhibition for antibiotics enhanced with 50 μl, 100 μl, 150 μl of grape seed mediated TiO2 nanoparticles were 16 mm, 18 mm and 19 mm in Streptococcus mutans. In lactobacillus species the zone of inhibition for standard antibiotics enhanced with 50 μl, 100 μl, 150 μl of grape seed mediated TiO2 nanoparticles remained constant at 35 mm. CONCLUSIONS The titanium dioxide nanoparticle mediated grape-seed extract showed excellent antimicrobial activity against lactobacillus and Streptococcus mutans. This proves that in future it can be used for treating these bacterial infections in the oral cavity after further in vivo studies. KEY WORDS Nanotechnology, Titanium Dioxide Nanoparticles, Grape Seed Extract, Lactobacillus, Enhanced Antibacterial, S. mutans

show abstract

Review on the role of Nanotechnology in Dentistry and Medicine

Cited by 8 publications

References 0 publications

Awareness of Use of Implant Coated with Nanoparticles with Antimicrobial Properties

Awareness of Use of Implant Coated with Nanoparticles with Antimicrobial Properties

The Characteristics and Potency of Limestone-based carbonate hydroxyapatite to Viability and Proliferation of Human Umbilical Cord Mesenchymal Stem Cell

Enhanced Antibacterial Effect of Titanium Dioxide Nanoparticles Mediated Grape Seed Extract on Oral Pathogens - Streptococcus mutans and Lactobacillus

Contact Info

Product

Resources

About