Review Paper: Role of Nitric Oxide on Dopamine Release and Morphine-Dependency

Motahari, Amir Arash; Sahraei, Hedayat; Meftahi, Gholam Hossein

doi:10.15412/j.bcn.03070401

Cited by 21 publications

(18 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At molecular level, the side effects of morphine have been shown by activating lipid per oxidation, increasing the free radicals such as reactive oxygen species (ROS) and releasing nitric oxide (NO). The release of NO could also be considered as a part of dependency on morphine (Motahari et al, 2016). These data indicate the role of oxidation and inflammation processes during morphine interaction with tissues.…”

Section: Introductionmentioning

confidence: 79%

Therapeutic Effect of Resveratrol on Morphine-Induced Damage in Male Reproductive System of Mice by Reducing Nitric Oxide Serum Level

et al. 2017

View full text Add to dashboard Cite

JALILI, C.; SALAHSHOOR, M. R. ; JALILI, F; KAKABARAEI, S.; AKRAMI, A.; SOHRABI, M.; AHOOKHASH, M. & GHANBARI, A.Therapeutic effect of resveratrol on morphine-induced damage in male reproductive system of mice by reducing nitric oxide serum level. Int. J. Morphol., 35(4):1342Morphol., 35(4): -1347Morphol., 35(4): , 2017. SUMMARY:Morphine is one of the naturally occurring phenanthrene alkaloids of opium that induces adverse effects on male reproductive system. Resveratrol is a phytoestrogen and antioxidant of red grape. The main goal is to investigate whether resveratrol could inhibit adverse effects of morphine on sperm cell viability, count, motility as well as testis histology, testosterone hormone and nitric oxide levels in mice. In the present study, 48 male rats were randomly divided into 8 groups (n=6) and were treated intraperitoneally for 14 days with normal saline, resveratrol (2, 8, 20 mg/kg/day), morphine (20 mg/kg/day) and morphine (20 mg/kg/day) + resveratrol (2, 8, 20 mg/kg/day). At the end of experiments, sperm parameters (sperm cell viability, count, motility and morphology), testis weight, the diameter of seminiferous tubules, testosterone hormone level and nitric oxide were analyzed. The data were analyzed by SPSS software for windows (version 20) using one-way ANOVA test followed by Tukey's post hoc test, and P<0.05 was considered significant. The results indicated that morphine administration significantly decreased testosterone level, count, viability and motility of sperm cells and testis weight and increased nitric oxide compared to the saline group (P=0.000). Administration of resveratrol and resveratrol plus morphine significantly increased motility, count and viability of sperm cells, somniferous tubule diameter and testosterone, while it decreased nitric oxide level compared to morphine group (P=0.025). It seems that resveratrol administration could increase the quality of spermatozoa and prevented morphine-induced adverse effects on sperm parameters.

show abstract

Section: Introductionmentioning

confidence: 79%

Therapeutic Effect of Resveratrol on Morphine-Induced Damage in Male Reproductive System of Mice by Reducing Nitric Oxide Serum Level

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Additionally, it has been reported that NO in the nucleus accumbens contributes to the acquisition and expression of morphine-induced CPP [27]. These data suggest that NO in other brain areas may be associated with addictive drug-induced CPP formation.…”

Section: Discussionmentioning

confidence: 80%

Nitric oxide in the medial prefrontal cortex contributes to the acquisition of cocaine place preference and synaptic plasticity in the laterodorsal tegmental nucleus

Kamii

Taoka

Minami

et al. 2017

Neuroscience Letters

View full text Add to dashboard Cite

Nitric oxide (NO), a gaseous neurotransmitter, is involved in a variety of brain functions, including drug addiction. Although previous studies have suggested that NO plays an important role in the development of cocaine addiction, the brain region(s) in which NO acts and how it contributes to cocaine addiction remain unclear. In this study, we examined these issues using a cocaine-induced conditioned place preference (CPP) paradigm and ex vivo electrophysiological recordings in rats. Specifically, we focused on the medial prefrontal cortex (mPFC) and laterodorsal tegmental nucleus (LDT), brain regions associated with cocaine CPP development and cocaine-induced plasticity. Intra-mPFC injection of the non-selective NO synthase (NOS) inhibitor L-NAME or the neuronal NOS (nNOS) selective inhibitor L-NPA during the conditioning phase disrupted cocaine CPP. Additionally, intra-mPFC injection of L-NPA prior to each cocaine injection prevented the induction of presynaptic plasticity, induced by repeated cocaine administration, in LDT cholinergic neurons. These findings indicate that NO generated in the mPFC contributes to the acquisition of cocaine CPP and the induction of neuroplasticity in LDT cholinergic neurons. Together with previous studies showing that NO induces membrane plasticity in mPFC neurons, that mPFC neurons project to the LDT, and that LDT activity is critical for the acquisition of cocaine CPP, the present findings suggest that NO-mediated neuroplasticity induced in the mPFC-LDT circuitry is critical for the development of cocaine addiction.

show abstract

“…Nevertheless, it has been indicated that a direct relationship between the central region of the amygdala and nicotine dependence (Salín-Pascual and Basañez-Villa, 2003). Considering the fact that different effects of nicotine have been shown in animals, the effects of nicotine are related to species, age, gender, previous history of receiving nicotine, and genetic factors (Neal et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Effect of amygdaloid complex inhibition on nicotine-induced conditioned place preference in rats

2017

J App Pharma Sci

View full text Add to dashboard Cite

Nicotine dependence is the major cause of cigarette smoking. The dependence occurred in the brain mesolimbic system and the amygdala has an important role in its initiation. Nicotine can activate dopaminergic neurons within the amygdaloid complex However, there is no evidence about complete inhibition of amygdala on nicotine dependence, thus in the present study we used conditioned-place preference (CPP) method to study the effect of transient inhibition of left and/or right side of the amygdala by lidocain e on nicotine reward properties in male Wistar rats. One week after two side cannulation and recovery the rats were conditioned to nicotine. Lidocaine hydrochloride (2%) was injected in amygdaloid complex, five min before each nicotine intraperitoneal (IP) injection for transient inhibition. On the test day, the animals were placed in the apparatus and their behaviors were recorded by a camera for 600 seconds. Then the records were analysis off line for sniffing, rearing, locomotion and compartment crossing. Three-way analysis of variance (ANOVA) was performed for statistical analysis. Our results showed that intra-peritoneal injection of nicotine (1 and 1.5 mg/kg) induced place preference. Transient inhibition of left or /and right side of the amygdaloid co mplex reduces nicotine place conditioning. In addition, rearing and compartment crossing also were reduced. However, when left side of the nucleus was inhibited, sniffing was increased, but when the right side was inhibited the sniffing was decreased. In conclusion, these results confirmed the involvement of both left and right sides of the amygdaloid complex in nicotine place conditioning.

show abstract

Review Paper: Role of Nitric Oxide on Dopamine Release and Morphine-Dependency

Cited by 21 publications

References 66 publications

Therapeutic Effect of Resveratrol on Morphine-Induced Damage in Male Reproductive System of Mice by Reducing Nitric Oxide Serum Level

Therapeutic Effect of Resveratrol on Morphine-Induced Damage in Male Reproductive System of Mice by Reducing Nitric Oxide Serum Level

Nitric oxide in the medial prefrontal cortex contributes to the acquisition of cocaine place preference and synaptic plasticity in the laterodorsal tegmental nucleus

Effect of amygdaloid complex inhibition on nicotine-induced conditioned place preference in rats

Contact Info

Product

Resources

About