Review: Solid Dispersion of Fenofibrate Using Poly Ethylene Glycol 6000

Abstract

This review aimed to find information about the solubility of the fenofibrate solid dispersion system using PEG 6000. Fenofibrate is an antihyperlipidemic drug that belongs to the Biopharmaceutical Classification System Class II (BCS II) with low solubility. To find information was by conducting a literature search in national and international journals in the last ten years (2010-2020) through websites, namely Google Scholar, Science Direct, NCBI, ResearchGate, and other trusted journals. Several keywords were used as follows: fenofibrate, solid dispersion, PEG 6000, and dissolution rate. The results of several research journals showed that the solid dispersion of fenofibrate using PEG 6000 made by various methods causes a reduction in particle size to increase the solubility and dissolution rate of fenofibrate. The solid dispersions system was made using several methods, namely fusion (melting), solvent evaporation, dropping, and co-grinding, which is a technique used to increase the solubility of a drug. PEG 6000 was chosen as the carrier because it has high hydrophilicity, is non-toxic, inert, economical, has a low melting point, and is dense at melting temperature to withstand crystallization. Thus it can be concluded that the manufacture of solid dispersion of fenofibrate using PEG 6000 and several methods showed the same results, namely an increase in solubility and dissolution rate.

Solid Dispersion Incorporated into Dissolving Microneedles for Improved Antifungal Activity of Amphotericin B: In Vivo Study in a Fungal Keratitis Model

“…SD is the dispersion of one or more hydrophobic drug substances in an inert carrier that is hydrophilic in the solid state . The SD formulation has the advantage of increasing drug solubility, thereby increasing dissolution rates, better bioavailability, and lower production costs compared to lipid-based formulations. , The types of polymers of the SD-AMB formulation are poly­(ethylene glycol) (PEG) and poly­(vinylpyrrolidone) (PVP), which can increase the solubility of drug substances while maintaining their activities. , PEG and PVP are inert polymers, stable, and significantly increase drug solubility as well as the drug release profile, which have been described previously . Although SD-AMB is considered capable of increasing the solubility of AMB, it is also necessary to overcome the low penetration ability and bioavailability of the drug, which is part of the problem with conventional AMB preparations.…”

“…20,21 PEG and PVP are inert polymers, stable, and significantly increase drug solubility as well as the drug release profile, which have been described previously. 22 Although SD-AMB is considered capable of increasing the solubility of AMB, it is also necessary to overcome the low penetration ability and bioavailability of the drug, which is part of the problem with conventional AMB preparations. Therefore, the development of dissolving microneedle (DMN) preparations is also needed to overcome this problem.…”

Pembentukan dan Karakterisasi Dispersi Padat Kandesartan Sileksetil-HPMC dengan Teknik Solvent Co-Evaporation

“…Terdapat beberapa metode yang dapat digunakan dalam preparasi sistem dispersi padat, beberapa yang paling umum dilakukan adalah metode peleburan dan solvent co-evaporation [16]. Pada metode peleburan, tahap pencampuran yang tidak sempurna antara obat dan pembawa dapat terjadi karena viskositas yang tinggi dari pembawa polimer.…”

“…Pada metode peleburan, tahap pencampuran yang tidak sempurna antara obat dan pembawa dapat terjadi karena viskositas yang tinggi dari pembawa polimer. Selain itu, obat yang tidak stabil secara termal dapat terdegradasi karena metode ini menggunakan suhu yang relatif tinggi pada saat preparasi [16].…”