Review: titanium and titanium alloy applications in medicine

Balažic, M.; Kopač, Janez; Jackson, Mark J.; Ahmed, Waqar

doi:10.1504/ijnbm.2007.016517

Cited by 215 publications

(121 citation statements)

References 98 publications

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“…The research field of bone tissue engineering applies the principles of biology and engineering to develop functional substitutes for damaged bone tissue (1). To restore, maintain and improve bone tissue function, three key elements are required: (1) a scaffold or carrier material combined with (2) cells and/or (3) bone stimulating molecules (e.g.…”

Section: Introductionmentioning

confidence: 99%

“…For these implants, the ultimate goal is to obtain a life-long secure anchoring of the implant in the native surrounding bone. Commercially pure titanium (cpTi) and Ti-6Al-4V alloys are the most commonly used metallic implant materials, as they are highly biocompatible materials with excellent mechanical properties and corrosion resistance (1)(2)(3)(4). The biocompatibility of titanium implants is attributed to the stable oxide layer (with a thickness of 3-10 nm) that spontaneously forms when titanium is exposed to oxygen (5,6).…”

Section: Introductionmentioning

confidence: 99%

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Organic–Inorganic Surface Modifications for Titanium Implant Surfaces

et al. 2008

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Abstract. This paper reviews current physicochemical and biochemical coating techniques that are investigated to enhance bone regeneration at the interface of titanium implant materials. By applying coatings onto titanium surfaces that mimic the organic and inorganic components of living bone tissue, a physiological transition between the non-physiological titanium surface and surrounding bone tissue can be established. In this way, the coated titanium implants stimulate bone formation from the implant surface, thereby enhancing early and strong fixation of bone-substituting implants. As such, a continuous transition from bone tissue to implant surface is induced. This review presents an overview of various techniques that can be used to this end, and that are inspired by either inorganic (calcium phosphate) or organic (extracellular matrix components, growth factors, enzymes, etc.) components of natural bone tissue. The combination, however, of both organic and inorganic constituents is expected to result into truly bone-resembling coatings, and as such to a new generation of surface-modified titanium implants with improved functionality and biological efficacy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Organic–Inorganic Surface Modifications for Titanium Implant Surfaces

et al. 2008

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“…Other challenges such as diffi culty in machining of titanium alloys due to high strength, low modulus of elasticity, and low thermal conductivity compared to steel makes it more expensive to manufacture patient-specifi c implants from these materials. 25 Finally, CM technologies can be energy intensive, producing signifi cant amounts of materials waste, and are not capable of easily producing implants with functional gradation.…”

Section: Advantages Of 3d Printing Toward Biomedical Devicesmentioning

confidence: 99%

3D printing of biomaterials

2015

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Three-dimensional (3D) printing represents the direct fabrication of parts layer-by-layer, guided by digital information from a computer-aided design fi le without any part-specifi c tooling. Over the past three decades, a variety of 3D printing technologies have evolved that have transformed the idea of direct printing of parts for numerous applications. Threedimensional printing technology offers signifi cant advantages for biomedical devices and tissue engineering due to its ability to manufacture low-volume or one-of-a-kind parts on-demand based on patient-specifi c needs, at no additional cost for different designs that can vary from patient to patient, while also offering fl exibility in the starting materials. However, many concerns remain for widespread applications of 3D-printed biomaterials, including regulatory issues, a sterile environment for part fabrication, and the achievement of target material properties with the desired architecture. This article offers a broad overview of the fi eld of 3D-printed biomaterials along with a few specifi c applications to assist the reader in obtaining an understanding of the current state of the art and to encourage future scientifi c and technical contributions toward expanding the frontiers of 3D-printed biomaterials.

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“…The choice of materials for medical implants is also based on properties such as corrosion resistance, biocompatibility, genotoxicity, carcinogenicity and cytotoxicity. 1,2 The variety of materials and alloys used for the manufacture of implants is enormous. The most commonly used metal biomaterials are stainless steel 316 L, Cr-Co alloys, commercially pure titanium and Ti-6Al-4V alloy.…”

Section: Introductionmentioning

confidence: 99%

Investigation Of Chromium-Cobalt Coated Scaffolds On Cell Cultures In Vitro

Kiradzhiyska¹,

Mantcheva²,

Mileva³

et al. 2014

Folia Medica

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IntroductIon:The use of diverse materials for medical purposes is continuously expanding. The modifcation of materials which are routinely applied in medical practice as well as the development and introduction of new materials require studies on their biological activity. The frst steps in this process are the preliminary short-term screening tests for cytotoxicity and biocompatibility performed on cell cultures. Methods: Coating of stainless steel (316 L) scaffolds with chromium-cobalt was performed by electroplating using the non-standard electrolyte Chromispel. The process was carried through at different cathode current densities and deposition times. The modifed surface of the metal scaffolds was studied for cytoxicity and cell vitality on the serum-free McCoyPlovdiv and the immortalized PDL cell cultures. results: Our results indicate no cytotoxic effect of the coated metal scaffolds. Even more, three of the samples stimulated the proliferation and growth of McCoy-Plovdiv cells. conclusIon: We have strong reasons to believe that chromium-cobalt coatings are promising for future studies and reliable for medical purposes. Key words: Cr-Co alloy, biocompatibility, cell cultures, McCoy-Plovdiv, PDL cell line Folia Medica 2014; 56(4): 275-281 Copyright © 2014 Medical University, Plovdiv РЕЗЮМЕ ВВедение: В последнее время всё более широко распространяется применение разнообразных материалов в медицинских целях. Модификация материалов, традиционно применяемых в медицинской практике, а также разработка и внедрение новых таковых требуют проведения исследований их биологической активности. Первыми шагами в этом процессе являются предварительные краткосрочные скрининг тесты на цитотоксичность и биосовместимость, которые проводятся на клеточных культурах. Методы: Покрытие пластинок из нержавеющей стали (316 L) хром-кобальтом было осуществлено посредством электролиза с применением нестандартного хлоридного электролита типа Chromispel. Процесс осуществлялся при различной катодной плотности тока и различной продолжительности депонирования покрытия. Модифицированная поверхность металлических пластинок была исследована на цитотоксичность и на клеточную витальность в среде бессывороточных McCoy-Plovdiv и иммортализованных PDL клеточных культур. Результаты: Полученные нами результаты показывают отсутствие цитотоксического эффекта металлических пластинок. Тем более, в трёх из проб было установлено стимулирование пролиферации и увеличение количества клеток McCoy-Plovdiv. заключение: Налицо серьёзные основания считать, что хром-кобальтовые покрытия являются перспективными для будущих исследований и надёжными для применения в медицинских целях. Ключевые слова: Cr-Co сплав, биосовместимость, клеточные куьлтуры, McCoy-Plovdiv, клеточная линия PDL Folia Medica 2014; 56(4): 275-281

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Review: titanium and titanium alloy applications in medicine

Cited by 215 publications

References 98 publications

Organic–Inorganic Surface Modifications for Titanium Implant Surfaces

Organic–Inorganic Surface Modifications for Titanium Implant Surfaces

3D printing of biomaterials

Investigation Of Chromium-Cobalt Coated Scaffolds On Cell Cultures In Vitro

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