Revised incidence of leptospirosis in Trinidad and Tobago, West Indies

Chadee, Dave D.; Mohan, Andrea; Cumberbatch, Anton; Adesiyun, Abiodun A.

doi:10.1016/j.actatropica.2009.12.004

Cited by 5 publications

(2 citation statements)

References 3 publications

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“…The annual incidence of human leptospirosis in Colombia during the last decade ranged from 1.1 to 5.4 cases per 100,000 inhabitants. This result is similar to that calculated by Costa et al 2 from passive surveillance systems and from epidemiological surveillance in Trinidad and Tobago (1.8 per 100,000 inhabitants) 27 . However, when compared to reports from other surveillance systems, this number is approximately ten times greater than that of Chile between 2003 and 2009 28 , but smaller than that of Malaysia between 2012 and 2013 (29.0 per 100,000) 29 .…”

Section: Discussionsupporting

confidence: 91%

Environmental and socioeconomic determinants of leptospirosis incidence in Colombia

et al. 2019

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Human leptospirosis is an infection that most often affects tropical countries. Since 2007, Colombia requires the notification of disease cases, enabling the observation of an increase in cases in recent years. The objectives of this article were to analyze environmental and socioeconomic variables and to evaluate their relationship with human leptospirosis cases. This is an ecological study on human leptospirosis cases aggregated by municipality and reported between 2007 and 2016. Spatial aggregation assessment was made using the Getis-Ord Gi method, and negative binomial regression was used to evaluate the relationship between environmental and socioeconomic variables with human leptospirosis. During the study period, 9,928 cases of human leptospirosis were reported, and 58.9% of municipalities reported at least one case. Four hotspots of human leptospirosis, including 18 municipalities, were identified. The results of the negative binomial model confirmed the importance of the effects of education, poverty and some climatic variables on the decadal incidence rate of human leptospirosis. Our results confirm the importance of socioeconomic determinants such as social marginality associated with violence and education, as well as ecological variables such as rainfall, height above sea level and forest coverage on the incidence rate of human leptospirosis at municipal scale.

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Section: Discussionsupporting

confidence: 91%

Environmental and socioeconomic determinants of leptospirosis incidence in Colombia

et al. 2019

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“…Over the last five years (2007–2011), the annual incidence of leptospirosis has ranged from <12 per 100,000 inhabitants in Martinique (2007) to >41 per 100,000 inhabitants in Guadeloupe (2011) (data from the NRC for Leptospirosis, Institut Pasteur, France), which is among the highest reported in the Caribbean (<2 per 100,000 inhabitants in Trinidad and Tobago [25], [26] and <13/100,000 inhabitants in Barbados [27]). …”

Section: Resultsmentioning

confidence: 99%

Serovar Diversity of Pathogenic Leptospira Circulating in the French West Indies

Bourhy

Storck²,

Théodose

et al. 2013

PLoS Negl Trop Dis

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BackgroundLeptospirosis is one of the most important neglected tropical bacterial diseases in Latin America and the Caribbean. However, very little is known about the circulating etiological agents of leptospirosis in this region. In this study, we describe the serological and molecular features of leptospires isolated from 104 leptospirosis patients in Guadeloupe (n = 85) and Martinique (n = 19) and six rats captured in Guadeloupe, between 2004 and 2012.Methods and FindingsStrains were studied by serogrouping, PFGE, MLVA, and sequencing 16SrRNA and secY. DNA extracts from blood samples collected from 36 patients in Martinique were also used for molecular typing of leptospires via PCR. Phylogenetic analyses revealed thirteen different genotypes clustered into five main clades that corresponded to the species: L. interrogans, L. kirschneri, L. borgpetersenii, L. noguchi, and L. santarosai. We also identified L. kmetyi in at least two patients with acute leptospirosis. This is the first time, to our knowledge, that this species has been identified in humans. The most prevalent genotypes were associated with L. interrogans serovars Icterohaemorrhagiae and Copenhageni, L. kirschneri serovar Bogvere, and L. borgpetersenii serovar Arborea. We were unable to identify nine strains at the serovar level and comparison of genotyping results to the MLST database revealed new secY alleles.ConclusionsThe overall serovar distribution in the French West Indies was unique compared to the neighboring islands. Typing of leptospiral isolates also suggested the existence of previously undescribed serovars.

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Epidemiology of Leptospirosis in Mesoamerica: Historical Perspectives on One Health Transmission

Erickson

2017

Curr Trop Med Rep

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Revised incidence of leptospirosis in Trinidad and Tobago, West Indies

Cited by 5 publications

References 3 publications

Environmental and socioeconomic determinants of leptospirosis incidence in Colombia

Environmental and socioeconomic determinants of leptospirosis incidence in Colombia

Serovar Diversity of Pathogenic Leptospira Circulating in the French West Indies

Epidemiology of Leptospirosis in Mesoamerica: Historical Perspectives on One Health Transmission

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