Revised National Tuberculosis Control Program regimens with and without directly observed treatment, short-course: A comparative study of therapeutic cure rate and adverse reactions

Sivaraj, Rajeshwari; Umarani, S.; Parasuraman, Subramani; Muralidhar, P

doi:10.4103/2229-3485.124557

Cited by 9 publications

(10 citation statements)

References 3 publications

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“…The TB is an important health problem in Iran and the issue has become even more and therefore, as a result of increasing drug-resistant strains, drug resistance complicates efforts to control TB. Moreover, the problem of extensively drug-resistant strains has recently been introduced ( 14 , 15 ). Despite effective drugs and diagnostic methods, TB is one of the main killers of humanity throughout history and is still growing ( 16 , 17 ).…”

Section: Introductionmentioning

confidence: 99%

Patients’ Experience of Tuberculosis Treatment Using Directly Observed Treatment, Short-Course (DOTS): A Qualitative Study

Behzadifar¹,

Mirzaei²,

Behzadifar³

et al. 2015

Iran Red Crescent Med J

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Background:Despite effective diagnosis and treatment, prevalence of tuberculosis (TB) is still growing. The directly observed treatment, short-course (DOTS) strategy to treat TB was introduced by the World Health Organization more than a decade ago. Little is known about patients’ experience of TB treatment, according to DOTS, in Iran.Objectives:This study aimed to understand the patients’ experience of tuberculosis treatment according to DOTS in Iran.Patients and Methods:This study is a qualitative study, using content analysis to examine patients’ experience of TB treatment and to understand their compliance during DOTS. In this study, a semi-structured interview with open questions was answered by 40 patients, who had a diagnosis of pulmonary and extrapulmonary tuberculosis, and improved during the course of their treatment. The method of sampling was purposive sample and the interview process lasted until data saturation.Results:Data analysis resulted in the extraction of six themes, which reflect the experiences of the study participants. The themes are: 1) individual factors; 2) change of the attitudes and beliefs of patients on TB treatment; 3) support terms of patients with tuberculosis; 4) the role of health care professionals; 5) social factors and 6) the financial burden.Conclusions:Successful completion of TB treatment requires an effective partnership between the patient and health care professionals, and a harmony between the cultural context, attitude of the patient, family support and health literacy. Future health policies should address these issues to improve patients’ adherence to DOTS.

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Section: Introductionmentioning

confidence: 99%

Patients’ Experience of Tuberculosis Treatment Using Directly Observed Treatment, Short-Course (DOTS): A Qualitative Study

Behzadifar¹,

Mirzaei²,

Behzadifar³

et al. 2015

Iran Red Crescent Med J

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“…The overall prevalence of ADRs with first-line anti-tuberculosis drugs is estimated to vary from 2.3% to 17% in various Indian studies. 10,12,15,20,[22][23][24]26,27 A study conducted by Mehrotra et al observed that the prevalence of ADRs in the initial intensive phase was 17.39%. 34 Another study conducted at a tertiary institute in Calcutta observed that the overall toxicity was found in 35% cases in the daily regimen group, whereas it was found to be 27.9% in the intermittent regimen group.…”

mentioning

confidence: 99%

Prevalence of adverse drug reaction with first-line drugs among patients treated for pulmonary tuberculosis

Singh

Prasad

Balasubramanian

et al. 2015

Clinical Epidemiology and Global Health

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Adverse drug reactions (ADRs) to first-line anti-tuberculosis drugs are common and may cause associated morbidity and even mortality if not recognized early. 1-3 The overall prevalence of ADRs with first-line anti-tuberculosis drugs is estimated to vary from 8.0% to 85%. They are observed more commonly in the intensive phase and do not differ with intermittent or daily intake of anti-tuberculosis drugs. The occurrence of ADRs may be influenced by multiple factors and may range from mild gastrointestinal disturbances to serious hepatotoxicity, peripheral neuropathy, cutaneous adverse effects, etc. Early recognition and appropriate management of these adverse effects might determine adherence and treatment success.

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“…Directly Observed Treatment Short course (DOTS) is one of the most cost-effective approaches to TB treatment [3,4]. The cure rate of TB was 82% among patients participating in the DOTS strategy worldwide, significantly higher than among those who did not take part in tDOTS (68%), in 2002 [5].…”

Section: Introductionmentioning

confidence: 99%

Enhanced directly-observed treatment short-course for tuberculosis control program in mountain areas of Taiwan

Huang

Tsao

Chen³

et al. 2019

J Infect Dev Ctries

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Introduction: Directly Observed Treatment Short course (DOTS) is one of the most cost-effective approaches for TB treatment. However, TB incidence rates remain high in the mountain areas of Taiwan. A lay health advisor (LHA) strategy is integrated into DOTS as an Enhanced-DOTS (E-DOTS) to provide trustworthy, culturally-specific services in mountain areas that consider the characteristics of local ethnic groups. Methodology: We recruited two Taiwanese indigenes as LHAs (one for each county) to screen close contacts in five townships of Hualien and Nantou counties from January 1, 2011 to December 31, 2013. Incidence and active finding rates of TB during the E-DOTS periods (2011-2013 for Hualien and 2012-2013 for Nantou) were compared with data when traditional DOTS was implemented (2006-2010 for Hualien and 2006-2011 for Nantou) to evaluate the effectiveness of E-DOTS using the before-and-after study design. Results: Incidence rate in Hualien decreased from 393.3 in 2011 to 235.7 in 2013 per 100,000 population and from 338 in 2012 to 235.5 in 2013 in Nantou mountain area. Furthermore, the active case finding rate increased from 15.42% in 2012 to 27.38% in 2013 as compared to an average of 6.5% for CDC, Taiwan, for the specified years. TB treatment success rates were significantly improved from an average of less than 80% to an average of higher than 90% after E-DOTS was implemented. Conclusions: Our findings highlighted that the use of LHAs in E-DOTS is an effective and applicable strategy for controlling tuberculosis in the mountain areas of Taiwan.

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Revised National Tuberculosis Control Program regimens with and without directly observed treatment, short-course: A comparative study of therapeutic cure rate and adverse reactions

Cited by 9 publications

References 3 publications

Patients’ Experience of Tuberculosis Treatment Using Directly Observed Treatment, Short-Course (DOTS): A Qualitative Study

Patients’ Experience of Tuberculosis Treatment Using Directly Observed Treatment, Short-Course (DOTS): A Qualitative Study

Prevalence of adverse drug reaction with first-line drugs among patients treated for pulmonary tuberculosis

Enhanced directly-observed treatment short-course for tuberculosis control program in mountain areas of Taiwan

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