Heavy-duty diesel trucks (HDDTs), the majority of which are used for freight movement, are major contributors of nitrogen oxides (NO x) and fine particulate matter (PM2.5) emissions. As a result, communities close to freight hubs such as ports, railyards, and distribution centers are disproportionately affected by diesel-related air pollution. This study evaluates the potential for emission-based access restriction and pricing strategy to reduce HDDT emissions in one such community in Southern California, U.S. Using a regional travel demand model with a dedicated heavy-duty truck submodel, it is assumed that a $10 emission fee is collected from HDDTs that do not meet the 2007 emission standards (i.e., model years 2009 and older) when they enter the community, which is considered to be a low emission zone (LEZ). The modeling results show that the emission fee diverts 60% of the pass-through trips made by HDDTs that do not meet the required emission standards away from the LEZ. The emission fee is found to reduce NO x, PM2.5, and carbon dioxide (CO2) emissions from HDDTs inside the LEZ by 37%, 38%, and 25%, respectively. Also, it is found that the emission fee has minimal impacts on the total emissions in the modeling area. The total NO x and CO2 emissions remain unchanged, while the total PM2.5 emission increases by 1%. These results demonstrate that emission-based access restriction and pricing can be an effective strategy for reducing truck emissions in communities heavily affected by truck traffic without resulting in adverse impacts on the regional emission inventory.