Revisiting the essential role of oxygen in wound healing

Gordillo, Gayle M.; Sen, Chandan K.

doi:10.1016/s0002-9610(03)00211-3

Cited by 311 publications

(291 citation statements)

References 38 publications

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“…In this study, for mathematical simplicity, the angiogenic response was estimated by the density of endothelial cells lining the capillary walls and was referred to as the capillary sprouts. Finally, oxygen is centrally essential for wound disinfection and to support the metabolism and signaling underlying wound repair (5,33).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Wound angiogenesis as a function of tissue oxygen tension: A mathematical model

Schugart

Friedman

Zhao

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

165

188

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Section: Resultsmentioning

confidence: 99%

“…Disruption of the vasculature at the wound site is responsible for wound-site hypoxia (5,6). Although hypoxia is generally recognized as a physiological cue to induce angiogenesis (7-10), severe hypoxia cannot sustain the growth of functional blood vessels (2,(11)(12)(13)(14).…”

mentioning

confidence: 99%

Wound angiogenesis as a function of tissue oxygen tension: A mathematical model

Schugart

Friedman

Zhao

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

165

188

View full text Add to dashboard Cite

show abstract

“…Oxygen partial pressure in wounds also has a regulatory component [55,56]. For example, it has been known since the 1980's that oxygen regulates angiogenesis [57,58].…”

Section: Supplemental Oxygen Tissue Oxygenationmentioning

confidence: 99%

Non-pharmacologic Prevention of Surgical Wound Infection

Sessler

2006

Anesthesiology Clinics of North America

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Wound infections are serious and relatively common postoperative complications. They are generally detected five to nine days after surgery and are usually attributed, even by surgeons, to poor surgical technique or failure to maintain sterility. However, it has been known for decades that all wounds become contaminated, often by bacteria from the skin or within the patient, and that it is host defense mechanisms that prevent most contamination from developing into clinical infections. Host defense is especially important during the initial hours following contamination, i.e., the immediate perioperative period.As might thus be expected, factors that improve host defense reduce infection risk. Many of these are under the direct control of anesthesiologists and are at least as important as appropriate use of prophylactic antibiotics, which halve infection risk [1]. This article will review nonpharmacologic methods of reducing infection risk, with special emphasis on methods available to anesthesiologists.

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“…These events will not be described in length here, since they have been comprehensively reviewed elsewhere. [6][7][8][9][10][11][12][13] Briefly however, a prolonged inflammatory phase is associated with a pathological state and often results in a 14 In particular, chronic venous ulcers remain within a sustained flux of inflammation and repair, with excessive host tissue damage, degradation and leukocyte infiltration delaying healing (Fig. 1b).…”

Section: Introductionmentioning

confidence: 99%