Revisiting the ‘sterilising cure’ terminology: a call for more patient-centred perspectives on HIV cure-related research

Newton, Luke; Necochea, Raúl; Palm, David; Taylor, Jeff; Barr, Liz; Patel, Hursch; Nathan, Anshula; Gerrard, Jo; Sylla, Laurie; Brown, Brandon; Dubé, Karine

doi:10.1016/s2055-6640(20)30054-6

Cited by 6 publications

(4 citation statements)

References 33 publications

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Section: Methodsmentioning

confidence: 99%

“…Recognising the nuances of defining cure with regards to HIV, 8,9 this definition was selected because it encompasses both the concept of a sterilising cure and a functional cure while communicating the primary outcomes for patients using easy to understand language. 10 We intentionally avoided using language that could be misconstrued, such as eradication or sterilising cure, 11,12 or terms that are currently not well defined in the HIV community, such as remission. 13,14 Ultimately, it was agreed that dividing the HIV cure target product profile into three modalities (combination therapies, exvivo gene therapies, and invivo gene therapies; figure 1, table 1) would ensure global appli cability while also recognising the distinct scientific and implementation challenges to delivery of such distinct interventions to certain populations through the mini mum and optimum goals.…”

Section: Initial Drafting Phasementioning

confidence: 99%

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Multi-stakeholder consensus on a target product profile for an HIV cure

et al. 2021

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Developing a cure for HIV is a global priority. Target product profiles are a tool commonly used throughout the drug development process to align interested parties around a clear set of goals or requirements for a potential product. Three distinct therapeutic modalities (combination therapies, ex-vivo gene therapy, and in-vivo gene therapy) for a target product profile for an HIV cure were identified. Using a process of expert face-to-face consultation and an online Delphi consultation, we found a high degree of agreement regarding the criteria for the optimum target product profile. Although the minimum attributes for a cure were debated, the broad consensus was that an acceptable cure need not be as safe and effective as optimally delivered antiretroviral therapy. An intervention that successfully cured a reasonable fraction of adults would be sufficient to advance to the clinic. These target product profiles will require further discussion and ongoing revisions as the field matures.

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Section: Methodsmentioning

confidence: 99%

Section: Initial Drafting Phasementioning

confidence: 99%

Multi-stakeholder consensus on a target product profile for an HIV cure

et al. 2021

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“…The first, termed ‘eradication cure’ or ‘sterilizing cure’ involves complete eradication of all replication-competent provirus from the infected person, including removal of viruses in cellular and anatomical reservoirs [ 2 , 3 ▪ , 10 , 25 , 26 ]. The second form is termed ‘functional cure’ or long-term remission whereby the viral reservoir is depleted to the extent that cessation of ART will not result in immediate viral rebound [ 2 , 3 ▪ , 10 , 25 , 26 ]. The gold standard of infectious disease cure is elimination of the pathogen; therefore, everyone will take eradication cure as the ideal.…”

Section: Acceptability Of a Functional Curementioning

confidence: 99%

HIV cure: an acceptability scientific agenda

Bonney

Lamptey

Kyei

2022

Current Opinion in HIV and AIDS

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Purpose of review Recent years have seen major investments into HIV cure research, seeking a permanent cure or remission. The purpose of this review is to consider how this important research agenda could be broadened to include issues of acceptability and appropriateness for different populations. Recent findings We discuss how the definitions of cure such as functional cure (remission) or complete cure (viral elimination) could be interpreted differently by various populations. We also discuss the different methods of cure and the importance of including Africa in cure research to ensure that emerging remedies could be trialled and utilized on the continent that bears the brunt of the AIDS pandemic. Summary We propose that the social science research of HIV cure acceptability should be done concurrently with the basic and clinical sciences, to ensure that cure methods consider stakeholder preferences.

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“…The other one is a functional cure or long-term remission: In that scenario, the reservoir size in patients will be dramatically reduced and be able to stop ART. 8 , 9 However, the virus will not be completely eliminated and patients will require regular monitoring.…”

Section: Introductionmentioning

confidence: 99%