Revival, modernization and integration of Indian traditional herbal medicine in clinical practice: Importance, challenges and future

Sen, Saikat; Chakraborty, Raja

doi:10.1016/j.jtcme.2016.05.006

Cited by 371 publications

(197 citation statements)

References 29 publications

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“…Indian traditional medicinal system like Siddha, Ayurveda and Unani has a very rich history of their effectiveness; modern research also acknowledged the importance of such medicine. Indian traditional medicine or medicinal plants are also considered as a vital source of new drug [18].…”

Section: Discussionmentioning

confidence: 99%

International Journal of Current Research in Biology and Medicine

Anitha¹,

Mustafa²

2017

Int. J. Curr. Res. Biol. Med.

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Psoriasis is an autoimmune skin disorder, which affects approximately 2-3% of the population worldwide. The current conventional therapy cannot offer satisfactory clinical results for most of the patients, largely due to the fact that many antipsoriatic drugs have serious side effects and psoriasis is prone to developing drug resistance after long term exposure. Natural products are used extensively throughout the world, at least in 70% of drugs available in the global market. However, there is a great threat to biodiversity due to overharvesting raw materials for herbal medicines and health care products. Since many medicinal plants are also in the extinct herb list, it is better to adapt mineral-based medicine practiced traditionally in India. An ancient system of traditional Indian medicine 'Siddha' uses herbs, metals, and minerals. Siddha system of medicine is one of the ancient traditional healing therapies known to the mankind since several centuries. It has numerous novel formulations which benefit the society for various ailments. SwarnaPushpa Rasa Chendhuram (SPRC) is kind of novel herbomineral preparation consist of mercury, sulfur, Stannum, Ammonium chloride and Benincasahispida. HaCaT cells are the immortalized human keratinocytes and have been extensively used to study the epidermal homeostasis and its pathophysiology. The main aim of the present investigation is to evaluate the anti-psoriatic and cytotoxic potential of the formulation SPRC using standard optimized HaCaT cell lines. The result obtained from the study reveals that the percentage of HaCaT cell viability decrease with increase in concentration of the siddha formulation SPRC. Least viability of cell was observed at the concentration of 100µg/ml shows 14.92%. Further the highest percentage inhibition of about 85.07% observed at 100µg/ml of SPRC. It was concluded from the present investigation that the siddha formulation SPRC possess significant anti-psoriatic and cytotoxic activity further actual active compounds responsible for potential cytotoxic has to be studied in detail with different models which exactly simulate the cell biology and actual pathophysiology of the psoriasis in humans.

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Section: Discussionmentioning

confidence: 99%

International Journal of Current Research in Biology and Medicine

Anitha¹,

Mustafa²

2017

Int. J. Curr. Res. Biol. Med.

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“…The available therapies or pharmacological drugs for the treatment of fatigue are very limited (Uthayathas et al, 2007), which necessitate potential alternatives from the extracts of traditional herbs and their respective performance of action are worth investigating (Tharakan et al, 2005). Herbs or other botanicals and their extracts or concentrates mentioned in literature as dietary supplements (Sen and Chakraborty, 2016) have the potential to mitigate fatigue, accelerate the elimination of fatigue-related metabolites and improve exercise performance (Tharakan et al, 2005, Lee et al, 2012and Zink 2016 (Radha and Laxmipriya, 2015;Bopana and Saxena, 2007;Kenjale et al, 2007;Shirolkar et al, 2013;Lamba et al, 2011;Mukhopadhya et al, 2001). In this context, the diversity of nutritional constituents from these herbs could be investigated for their possible role in alleviating fatigue generated during exercise performance.…”

Section: Issn: 2319-7706 Volume 6 Number 4 (2017) Pp 2164-2178mentioning

confidence: 99%

Development of Poly Herbal Granules and its Anti-Fatigue Efficacy in Swiss Mice

Devi¹,

Nalwade²,

Rajurkar³

2017

Int.J.Curr.Microbiol.App.Sci

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The current study sought to investigate the anti-fatigue efficacy of poly herbal granule (PHG) formulations of the extracts of Asparagus racemosus, Chlorophytum borivilianum, Tinospora cordifolia, Tribulus terrestris and Withania somnifera enriched with general tonic and health promoting properties based on Aloe vera gel and soyabean whey in Swiss mice. The nutrient compositions of the selected PHG exhibited that the carbohydrates were the major constituents in both AVII and SBWII, followed by protein and total ash. Fat contents were 0.96 and 1.18 g100g -1 in AVII and SBWII, respectively. The energy levels of AVII and SBWII were 378 and 377 kcal100g -1 , correspondingly. Higher contents of Ca (70.20 mg100g -1 ), Mg (85.27mg100g -1 ) and P (61.55 mg100g -1 ) were observed in SBWII. The trace elements revealed that, Zn and Fe content were 1.84 and 8.63mg100g-1 in AVII and 1.85 and 7.85mg100g -1 in SBWII, respectively. The retention and stability of Vitamin C, total sugar, reducing sugar and non-reducing sugar for 270 days illustrated the storage life of the product in ambient condition. The body weight of mice, swimming time and corresponding biochemical parameters including haemoglobin, serum protein and blood glucose level were measured by standard method. The oral administration with PHG supplement for 30 days markedly increased the body weight (11.40-11.80%), haemoglobin (11.82-12.46%), serum protein (3.77-6.02%) of the mice. Following forced swimming test (FST), prolonged exhaustive exercise time of 231.02 (AVII), 237.50 (SBWII) minutes were recorded for PHG supplemented groups which were 36.23 (AVII) and 37.97 (SBWII) per cent longer than that of the control group. The minute increase of blood glucose levels (4.51-4.37%) in PHG supplemented Swiss mice after FST as compared to tremendous increase in blood glucose level (40.07%) in the control group illustrated the anti-fatigue activity of PHG. K e y w o r d s

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“…Due to these enormous medicinal properties, plants are exclusively used to discover drug-like molecules in the current era of drug discovery [13,14]. Phytomedicines are playing a crucial role in the health management systems in developing countries including India [15][16][17]. In recent decades, medicinal plants have been getting wide attention and recognition in the global biotechnology market [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Uttarakhand Medicinal Plants Database (UMPDB): A Platform for Exploring Genomic, Chemical, and Traditional Knowledge

Kumar

Sharma

et al. 2018

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Abstract:Medicinal plants are the main natural pools for the primary health care system, ethno-medicine, as well as traditional Indian system of several medicines. Uttarakhand also known as 'Herbal State', is a rich source of medicinal plants and traditional medicinal knowledge. A great deal of information about medicinal plants of Uttarakhand is scattered in different forms. Although many medicinal plant databases are available, currently there is no cohesive manually curated database of medicinal plants widely distributed in Uttarakhand state. A comprehensive database has been developed, known as the Uttarakhand Medicinal Plants Database (UMPDB). UMPDB provides extensive information on botanical name, common name, taxonomy, genomic taxonomy id, habit, habitat, location in Uttarakhand, part use, medicinal use, genomic information (including number of nucleotides, proteins, ESTs), chemical information, and scientific literature. Annotated medicinal plants integrated in the current version of the database were collected from the existing books, databases, and available literature. The current version of UMPDB contains the 1127 records of medicinal plants which belong to 153 plant families distributed across 13 districts of Uttarakhand. The primary goal of developing this database is to provide traditional, genomic, and chemical descriptions of the medicinal plants exclusively found in various regions of Uttarakhand. We anticipate that embedded information in the database would help users to readily obtain desired information.

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Revival, modernization and integration of Indian traditional herbal medicine in clinical practice: Importance, challenges and future

Cited by 371 publications

References 29 publications

International Journal of Current Research in Biology and Medicine

International Journal of Current Research in Biology and Medicine

Development of Poly Herbal Granules and its Anti-Fatigue Efficacy in Swiss Mice

Uttarakhand Medicinal Plants Database (UMPDB): A Platform for Exploring Genomic, Chemical, and Traditional Knowledge

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