2012
DOI: 10.2174/157015912804499456
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Revolutionary Impact of Nanodrug Delivery on Neuroscience

Abstract: Brain research is the most expanding interdisciplinary research that is using the state of the art techniques to overcome limitations in order to conduct more accurate and effective experiments. Drug delivery to the target site in the central nervous system (CNS) is one of the most difficult steps in neuroscience researches and therapies. Taking advantage of the nanoscale structure of neural cells (both neurons and glia); nanodrug delivery (second generation of biotechnological products) has a potential revolu… Show more

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Cited by 43 publications
(11 citation statements)
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“…Principally, nanostructures have the ability to preserve, target and bypass first-pass metabolism; thus, it increases the bioavailability. [36,37] The improvement in histological architecture was also evident through cauda epididymal sperm count, which reflected better count every passing observation day.…”
Section: Discussionmentioning
confidence: 85%
“…Principally, nanostructures have the ability to preserve, target and bypass first-pass metabolism; thus, it increases the bioavailability. [36,37] The improvement in histological architecture was also evident through cauda epididymal sperm count, which reflected better count every passing observation day.…”
Section: Discussionmentioning
confidence: 85%
“…Cellular uptake of 100-nm nanoparticles was found to be 2.5-fold higher in comparison to particles of 1-ÎŒm diameter [56]. Similarly, surface-curvature is important to detect aggregation and receptor-binding ability [57]. A perfect integrin-targeted nanoparticulate system should reach its target at ease, get recognized by the receptor, bind to the integrins and deliver its payload to the tumor site with minimum drug loss to the healthy tissues.…”
Section: Integrin-selective Drug/gene Delivery Platformsmentioning
confidence: 99%
“…As nanocarriers can be used polymerparticles, nanobeads, nanotubes, and quantumdots. Nanodrugs [26] can be produced in various forms such as nanosuspension, nanoemulsion, nanogels, and nanospheres. It is believed that the nanopharmaceutical research may be very beneficial for improving drug stability and delivery.…”
Section: Gene Silencing Techniques Via Trans-acting Ribozymesmentioning
confidence: 99%