Reward Circuitry and Motivational Deficits in Social Anxiety Disorder: What Can Be Learned From Mouse Models?

Carlton, Corinne N.; Sullivan-Toole, Holly; Ghane, Merage; Richey, J. Anthony

doi:10.3389/fnins.2020.00154

Cited by 16 publications

(10 citation statements)

References 92 publications

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“…Here, social avoidance reflects anxiety-like behaviour under social circumstances, as social approach is also directed by motivation [ 68 , 69 , 70 ]. Reduced motivational salience associated with natural rewarding stimuli is specifically reported in social anxiety disorders and substance abuse, suggesting an involvement of DA-driven reward circuitry [ 71 ]. Accordingly, at WD10, rats appeared to suffer from a higher conflict between the anxiogenic novel environment and hunger-induced behaviour in the NSFT as shown by an increase in latency to eat with respect to BD and controls.…”

Section: Discussionmentioning

confidence: 99%

Binge-like Alcohol Exposure in Adolescence: Behavioural, Neuroendocrine and Molecular Evidence of Abnormal Neuroplasticity… and Return

et al. 2021

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Binge alcohol consumption among adolescents affects the developing neural networks underpinning reward and stress processing in the nucleus accumbens (NAc). This study explores in rats the long-lasting effects of early intermittent exposure to intoxicating alcohol levels at adolescence, on: (1) the response to natural positive stimuli and inescapable stress; (2) stress-axis functionality; and (3) dopaminergic and glutamatergic neuroadaptation in the NAc. We also assess the potential effects of the non-intoxicating phytocannabinoid cannabidiol, to counteract (or reverse) the development of detrimental consequences of binge-like alcohol exposuredimensions. Our results show that adolescent binge-like alcohol exposure alters the sensitivity to positive stimuli, exerts social and novelty-triggered anxiety-like behaviour, and passive stress-coping during early and prolonged withdrawal. In addition, serum corticosterone and hypothalamic and NAc corticotropin-releasing hormone levels progressively increase during withdrawal. Besides, NAc tyrosine hydroxylase levels increase at late withdrawal, while the expression of dopamine transporter, D1 and D2 receptors xpression is dynamically altered during binge and withdrawal. Furthermore, the expression of markers of excitatory postsynaptic signaling —PSD95; Homer-1 and -2 and the activity-regulated spine-morphing proteins Arc, LIM Kinase 1 and FOXP1—increase at late withdrawal. Notably, subchronic cannabidiol, during withdrawal, attenuates social- and novelty-induced aversion and passive stress-coping and rectifies the hyper-responsive stress axis and NAc dopamine and glutamate-related neuroplasticity. Overall, the exposure to binge-like alcohol levels in adolescent rats makes the NAc, during withdrawal, a locus minoris resistentiae as a result of perturbations in neuroplasticity and in stress-axis homeostasis. Cannabidiol holds a promising potential for increasing behavioural, neuroendocrine and molecular resilience against binge-like alcohol level’s harmful effects.

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Section: Discussionmentioning

confidence: 99%

Binge-like Alcohol Exposure in Adolescence: Behavioural, Neuroendocrine and Molecular Evidence of Abnormal Neuroplasticity… and Return

et al. 2021

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“…Indeed, alterations in reward processing underlie psychopathology associated with adverse childhood experiences. Specifically, depressive symptomatology (anhedonia) is marked by blunted neural response to reward ( Der-Avakian and Markou, 2012 , Wiggins et al, 2017 ), whereas substance use ( Tanabe et al, 2019 ), irritability ( Dougherty et al, 2018 ), and, to a lesser extent, anxiety symptoms ( Carlton et al, 2020 ) are associated with outsized neural sensitivity to reward and, in the case of irritability, outsized sensitivity to non-reward (i.e., loss, failing to receive a reward) as well ( Deveney et al, 2013 , Hodgdon et al, 2021 , submitted).…”

Section: Introductionmentioning

confidence: 99%

Contributions of childhood abuse and neglect to reward neural substrates in adolescence

Yang

Owen

et al. 2021

NeuroImage: Clinical

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“…Supporting the notion of reward-relevant PA states having an impact on social anxiety symptoms and social functioning, previous work has indicated that specific activated PA facets (e.g., self-assurance) are linked to reward seeking and to the dopaminergic system, which governs motivational and approach-related behaviors (see DeYoung, 2013). This is of particular relevance here, in that prior work has established that reward neurobiology and its behavioral correlates are functionally suppressed in SAD (Cremers, Veer, Spinhoven, Rombouts, & Roelofs, 2015;Richey et al, 2017) and dysfunction in reward circuitry has been linked to motivational deficits exhibited in SAD (for review see Carlton, Sullivan-Toole, Ghane, & Richey, 2020). Together, predictions posited by the Broaden and Build theory, combined with results from previous work demonstrating the relationship between blunted reward functioning and social anxiety, suggest that there may be a distinct linkage between motivational states contained within the PA construct and social anxiety symptoms.…”

Section: Motivationally-relevant Domains Of Pa Are Related To Social Anxietymentioning

confidence: 86%

Motivationally-relevant domains of positive affectivity are differentially related to social anxiety symptoms

et al. 2021

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Background: This study investigated the extent to which specific facets of positive affectivity (PA) demonstrate differential relationships with social anxiety symptomatology as well as social functioning. Following the conceptual framework of the Broaden and Build theory, as well as prior work demonstrating reward-based linkages to specific PA subdomains, we hypothesized that motivationally-valenced PA facets would show distinct associations with social anxiety and social functioning measures. Methods:Two samples (N = 446 and N = 375) completed self-report measures of PA, social anxiety, internalizing symptoms, and social functioning. Correlational, multiple and logistic regression, and contrast analyses of correlated correlation coefficients were used to identify the presence and magnitude of relationships between PA facets and symptom measures.Results: Relationships between social anxiety and specific subdomains of PA appeared to depend on the motivational relevance of each facet. Specifically, self-assurance was associated with social anxiety symptoms above and beyond other PA facets and negative affect.Additionally, contrast analyses indicated that motivationally-valenced PA facets were stronger predictors than non-motivationally-valenced PA facets for social anxiety symptoms. Conclusions:These results demonstrate a statistically significant divergence between motivationally-valenced subdomains of PA and non-motivationally-valenced subdomains of PA, as they relate to social anxiety symptom severity.

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Reward Circuitry and Motivational Deficits in Social Anxiety Disorder: What Can Be Learned From Mouse Models?

Cited by 16 publications

References 92 publications

Binge-like Alcohol Exposure in Adolescence: Behavioural, Neuroendocrine and Molecular Evidence of Abnormal Neuroplasticity… and Return

Binge-like Alcohol Exposure in Adolescence: Behavioural, Neuroendocrine and Molecular Evidence of Abnormal Neuroplasticity… and Return

Contributions of childhood abuse and neglect to reward neural substrates in adolescence

Motivationally-relevant domains of positive affectivity are differentially related to social anxiety symptoms

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