Reward Sensitivity, Cognitive Response Style, and Inflammatory Response to an Acute Stressor in Adolescents

Moriarity, Daniel P.; Ng, Tommy H.; Curley, Erin; McArthur, Brae Anne; Ellman, Lauren M.; Coe, Christopher L.; Abramson, Lyn Y.; Alloy, Lauren B.

doi:10.1007/s10964-020-01216-y

Cited by 15 publications

(13 citation statements)

References 45 publications

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“…Alternatively, appropriate use of composite variables can reduce the error-to-signal ratio by aggregating theoretically-relevant shared variance. In light of these considerations, some researchers have used inflammatory composite variables created using the sum of a set of standardized proteins (e.g., Moriarity et al., 2020a , Moriarity et al., 2020b , Moriarity et al., 2020c ). However, the use of composites uninformed by first investigating dimensionality is problematic.…”

Section: Methodsmentioning

confidence: 99%

“…Immunopsychiatry is a subfield of psychoneuroimmunology that integrates immunological and psychopathological processes with promise for improving the classification, identification, and treatment of psychopathology. Inflammation, part of the immune system's response to illness and injury, is gaining evidence as a transdiagnostic risk factor for psychopathology ( Michopoulos et al., 2016 ; Moriarity et al., 2020a , Moriarity et al., 2020b , Moriarity et al., 2020c ; Rosenblat et al., 2014 ). In particular, much work has studied the relationship between inflammation and depression, which will be the focus of this mini-review to provide focus, although the future directions described herein are broadly generalizable.…”

Section: Introductionmentioning

confidence: 99%

“…There is converging evidence from experimentally-administered endotoxin ( Dantzer and Kelley, 2007 ; Watkins and Maier, 1999 ), behavioral reactions to immunotherapy and vaccinations ( Capuron et al., 2001 , 2002 ; Kuhlman et al., 2018 ), and natural fluctuations in inflammatory proteins ( Moriarity et al., 2020a ) that inflammation could play a causal role in the pathogenesis of depression. In fact, the relationship might be bidirectional ( Huang et al., 2019 ; Moriarity et al., 2020a , Moriarity et al., 2020b , Moriarity et al., 2020c ). Additionally, inflammation might be a viable adjunctive treatment target ( Nettis et al., 2021 ).…”

Section: Introductionmentioning

confidence: 99%

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Building a replicable and clinically-impactful immunopsychiatry: Methods, phenotyping, and theory integration

Moriarity

2021

Brain, Behavior, & Immunity - Health

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Immunopsychiatry is a subfield of psychoneuroimmunology that integrates immunological and psychopathological processes with promise for improving the classification, identification, and treatment of psychopathology. Using research on the relationship between inflammation and depression as a running example, this mini-review will discuss three areas of work that should be emphasized in future research to maximize the replicability and clinical impact of the field: 1) methodology with respect to planning data collection and statistical analyses with measurement properties and conceptually important sources of variance in mind, 2) characterizing inflammatory phenotypes of psychopathology, and 3) the integration of inflammatory processes into robust, extant psychosocial theoretical frameworks of psychopathology risk. Consistent, parallel growth in all three areas will ensure immunopsychiatry research is replicable, contributes to understanding of how (and for whom) the immune system is associated with psychiatric symptoms, and increases the flexibility and power of personalized treatment planning.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Building a replicable and clinically-impactful immunopsychiatry: Methods, phenotyping, and theory integration

Moriarity

2021

Brain, Behavior, & Immunity - Health

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“…In addition to the actual method of data collection (e.g., specific self-report measure, particular imaging scanner model), some biological variables can be measured from different sources. For example, inflammatory proteins most frequently are measured via assaying blood samples (Moriarity et al, 2020a;Muscatell et al, 2016), but salivary measures have been increasing in popularity because they are less expensive and invasive than blood-based methods. However, the utility and comparability of these methods has been questioned as salivary markers of inflammation might reflect local, rather than systemic, immune function (Riis et al, 2015).…”

Section: Temporal Stabilitymentioning

confidence: 99%

Back to Basics: The Importance of Measurement Properties in Biological Psychiatry

Moriarity

Alloy

2021

Neuroscience & Biobehavioral Reviews

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Biological psychiatry is a major funding priority for organizations that fund mental health research (e.g., National Institutes of Health). Despite this, some have argued that the field has fallen short of its considerable promise to meaningfully impact the classification, diagnosis, and treatment of psychopathology. This may be attributable in part to a paucity of research about key measurement properties ("physiometrics") of biological variables as they are commonly used in biological psychiatry research. Specifically, study designs informed by physiometrics are more likely to be replicable, avoid poor measurement that results in misestimation, and maximize efficiency in terms of time, money, and the number of analyses conducted. This review describes five key physiometric principles (internal consistency, dimensionality, method-specific variance, temporal stability, and temporal specificity), illustrates how lack of understanding about these characteristics imposes meaningful limitations on research, and reviews examples of physiometric studies featuring a variety of popular biological variables to illustrate how this research can be done and substantive conclusions drawn about the variables of interest.

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“…Specifically, psychoneuroimmunology studies heavily feature variations of the Trier Social Stress Task (TSST; Kirschbaum et al, 1993), which involves participants preparing and delivering a public presentation. Given evidence that inflammation and reward sensitivity/processing are related (Chat et al, 2021;Felger et al, 2016;Moriarity, Ng, Curley, et al, 2020;Moriarity, Ng, Titone, et al, 2020), the development of a reward-salient stressor is an important step forward for immunopsychiatry and stress research at large. Specifically, a validated reward-salient stress task would facilitate research in which theories about reward sensitivity, processing, and/or goal frustration can be tested experimentally with a complementary stressor.…”

Section: Introductionmentioning

confidence: 99%

Protocol for Project MIME: Motivation, Inflammation, and Mood in Emerging Adults

Moriarity¹

2022

Preprint

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Background: Atypical inflammatory biology is gaining evidence as a risk factor for mood psychopathology; however, little work has attempted to integrate inflammation into extant psychosocial frameworks of risk. Recent work using secondary data analysis has investigated the possibility of an immunocognitive model of mood disorders, in which cognitive vulnerabilities (i.e., rumination on positive or negative affect) increase the effect that arousal-related characteristics (e.g., reward sensitivity) have on inflammatory biology in ways that may confer risk for depression and hypo/mania symptoms. Project MIME (Motivation, Inflammation, and Mood in Emerging Adults) was designed to test this model in the context of a novel, reward-salient stressor (the Anger Incentive Delay Task, AIDT). Methods: This NIMH-funded study will result in a dataset of approximately 100 college undergraduates from a large university in Pennsylvania, United States of America. Eligible participants are recruited from an online screener, have to be 18-22 years old, fluent in English, and successfully answer several items designed to test whether participants randomly answer questions on the screener. Eligible participants are invited to an in-person visit in which they completed the AIDT, blood draws pre- and 50 minutes post-AIDT, and self-report questionnaires. Participants also complete a set of online questionnaires two weeks after the in-person visit.Discussion: Consistent with calls from the NIH director, this study seeks to diversify the tools used in stress research by validating a novel reward-salient stressor (in contrast to the field’s reliance on social stressors) with respect to affective and immunological stress reactivity. In addition to this methodological goal, Project MIME is the first study specifically designed to test the immunocognitive model of mood psychopathology. Given the integration of several malleable treatment targets (approach behavior, emotion regulation, inflammation) into this model, results from this study could inform comprehensive, flexible intervention strategies for mood disorder prevention and treatment.

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Reward Sensitivity, Cognitive Response Style, and Inflammatory Response to an Acute Stressor in Adolescents

Cited by 15 publications

References 45 publications

Building a replicable and clinically-impactful immunopsychiatry: Methods, phenotyping, and theory integration

Building a replicable and clinically-impactful immunopsychiatry: Methods, phenotyping, and theory integration

Back to Basics: The Importance of Measurement Properties in Biological Psychiatry

Protocol for Project MIME: Motivation, Inflammation, and Mood in Emerging Adults

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