Reward sensitivity in Parkinson's patients with binge eating

Terenzi, Damiano; Rumiati, Raffaella I.; Catalan, Mauro; Antonutti, Lucia; Furlanis, Giovanni; Garlasco, Paolo; Polverino, Paola; Bertolotti, Claudio; Manganotti, Paolo; Aiello, Marilena

doi:10.1016/j.parkreldis.2018.03.007

Cited by 12 publications

(10 citation statements)

References 29 publications

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“…Choice impulsivity refers to maladaptive decision-making in which smaller-sooner rewards could be favored in comparison with larger-later ones, following a function in which the temporal variable became crucial: the so-called temporal discounting (Rung et al, 2019 ). However, there are only few studies aimed at deepening both of these domains and only a few bodies of evidence exist about exacerbated incentive motivation (Terenzi et al, 2018 ) and choice impulsivity (Martini et al, 2018 ) in PD + ICBs patients (Dawson et al, 2018 ). We seek to clarify the role of incentive motivation and choice impulsivity by comparing the performance of PD + ICBs and PD patients without ICBs (PD-ICBs) on objective and subjective measures of these processes.…”

Section: Introductionmentioning

confidence: 99%

Motivational and myopic mechanisms underlying dopamine medication-induced impulsive-compulsive behaviors in Parkinson's disease

Dawson

Ortelli

Carter

et al. 2023

Front. Behav. Neurosci.

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IntroductionDopaminergic medications can trigger impulsive-compulsive behaviors (ICBs) in pre-disposed patients with Parkinson's disease (PD), but what this implies on a neurocognitive level is unclear. Previous findings highlighted potentially exacerbated incentive motivation (willingness to work for rewards) and choice impulsivity (preferring smaller, immediate rewards over larger, delayed rewards) in PD patients with ICBs (PD + ICBs).MethodsTo deeply understand this evidence, we studied 24 PD + ICBs and 28 PD patients without ICBs (PD-ICBs). First of all, patients underwent the assessment of impulsivity traits, mood, anxiety, and addiction condition. We further administered robust objective and subjective measures of specific aspects of motivation. Finally, we explored whether these processes might link to any heightened antisocial behavior (aggression and risky driving) in PD + ICBs.ResultsHigh levels of positive urgency trait characterized PD + ICBs. They choose to exert more effort for rewards under the conditions of low and medium reward probability and as reward magnitude increases. Findings on choice impulsivity show a great tendency to delay discounting in PD + ICBs, other than a high correlation between delay and probability discounting. In addition, we found what appears to be the first evidence of heightened reactive aggression in PD patients with ICBs. Exacerbated incentive motivation and delay discounting trended toward positively predicting reactive aggression in PD + ICBs.DiscussionOur promising results suggest that there might be immense value in future large-scale studies adopting a transdiagnostic neurocognitive endophenotype approach to understanding and predicting the addictive and aggressive behaviors that can arise from dopaminergic medication in PD.

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Section: Introductionmentioning

confidence: 99%

Motivational and myopic mechanisms underlying dopamine medication-induced impulsive-compulsive behaviors in Parkinson's disease

Dawson

Ortelli

Carter

et al. 2023

Front. Behav. Neurosci.

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“…Therefore, understanding the relationship between neural circuits underpinning eating behaviour and brain mechanisms related to implicit attitudes, which are measures of automatic affective evaluation of food or body ( Greenwald and Farnham, 2003 ; De Houwer et al , 2009 ), is of great interest. The low number of studies prevents to delineate clear conclusions on this aspect, but it is worth noting that one paper assessing reward sensitivity for food in patients with PD in dopamine replacement treatment reported discrepancies between implicit and explicit food attitudes in patients with PD and binge eating, in line with findings with other samples of disordered eating ( Papies et al , 2009 ; Terenzi et al , 2018 ). One ERP study showed task-related differences in the N400 component only in patients with BN, supporting the hypothesis that implicit attitudes in EDs could be associated to anomalous brain response at an early stage ( Blechert et al , 2011 ).…”

Section: Discussionmentioning

confidence: 80%

“…Six studies investigated the neurobiological underpinnings of implicit attitudes toward food or body images ( Table 2 ). Three studies were carried out with healthy participants ( Mattavelli et al , 2015 ; Cazzato et al , 2017 ; Hall et al , 2018a ), two involved patients with EDs ( Blechert et al , 2011 ; Mattavelli et al , 2019 ) and one study assessed patients with Parkinson’s disease (PD) treated with dopaminergic replacement ( Terenzi et al , 2018 ). Four of these studies investigated the possibility to modulate IAT performances with non-invasive brain stimulation techniques applied to different cortical regions ( Mattavelli et al , 2015 , 2019 ; Cazzato et al , 2017 ; Hall et al , 2018a ).…”

Section: Resultsmentioning

confidence: 99%

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A systematic review of implicit attitudes and their neural correlates in eating behaviour

Gallucci

Mauro

Pisoni

et al. 2020

Social Cognitive and Affective Neuroscience

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An increasing number of studies suggests that implicit attitudes toward food and body shape predict eating behaviour and characterize patients with eating disorders (EDs). However, literature has not been previously analysed, thus differences between patients with EDs and healthy controls and the level of automaticity of the processes involved in implicit attitudes are still matters of debate. The present systematic review aimed to synthetize current evidence from papers investigating implicit attitudes towards food and body in healthy and EDs populations. PubMed, EMBASE (Ovid), PsycINFO, Web of Science and Scopus were systematically screened and 183 studies using different indirect paradigms were included in the qualitative analysis. The majority of studies reported negative attitudes towards overweight/obese body images in healthy and EDs samples and weight bias as a diffuse stereotypical evaluation. Implicit food attitudes are consistently reported as valid predictors of eating behaviour. Few studies on the neurobiological correlates showed neurostimulation effects on implicit attitudes, but the automaticity at brain level of implicit evaluations remains an open area of research. In conclusion, implicit attitudes are relevant measures of eating behaviour in healthy and clinical settings, although evidence about their neural correlates is limited.

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“…Clinically, PD is defined as a progressive movement disorder, including bradykinesia, rigidity, and rest tremor [ 7 , 8 ]. Furthermore, PD is often characterized by different nonmotor symptoms affecting sensory perception, cognition, mood, motivation, autonomic functions, and sleep, among others [ 9 , 10 , 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Nutrition and Gut–Brain Pathways Impacting the Onset of Parkinson’s Disease

2022

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An emerging body of literature suggests that long-term gut inflammation may be a silent driver of Parkinson’s disease (PD) pathogenesis. Importantly, specific nutritive patterns might improve gut health for PD risk reduction. Here, we review the current literature on the nutritive patterns and inflammatory markers as a predictor for early detection of PD. This knowledge might be used to foster the detection of early nutritive patterns and preclinical biomarkers to potentially alter PD development and progression.

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Reward sensitivity in Parkinson's patients with binge eating

Cited by 12 publications

References 29 publications

Motivational and myopic mechanisms underlying dopamine medication-induced impulsive-compulsive behaviors in Parkinson's disease

Motivational and myopic mechanisms underlying dopamine medication-induced impulsive-compulsive behaviors in Parkinson's disease

A systematic review of implicit attitudes and their neural correlates in eating behaviour

Nutrition and Gut–Brain Pathways Impacting the Onset of Parkinson’s Disease

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