We present a liquid refractive index sensor based on a photonic crystal waveguide slab structure. Sensing mechanism employed in this study is based on the shift in cut-o wavelength as the lattice holes are selectively in ltrated. Three-dimensional plane-wave expansion and nite-di erence time-domain methods are used to determine the band structure and transmission spectra, respectively. First, the sensitivity of the device is analyzed for the structure where only the rst rows of holes adjacent to the line-defect are in ltrated. In addition, this analysis is repeated for a range of hole diameters. Second, the e ects of in ltrated holes which are placed in the line-defect are investigated. As these in ltrated central holes are introduced, the proposed device exhibits 5.3 times improved sensitivity.