RF magnetron sputtering mediated NiTi/Ag coating on Ti-alloy substrate with enhanced biocompatibility and durability

Elangovan, T.; Dhandapani, Vishnu Shankar; Dharmalingam, Karthigaimuthu; Marimuthu, Mohana; Veerapandian, Murugan; Arumugam, M.; Kim, Sang-Hyo; Kim, Byungki; Ramasundaram, Subramaniyan; Kim, Dae Eun

doi:10.1016/j.msec.2019.01.099

Cited by 22 publications

(12 citation statements)

References 44 publications

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“…Besides, Otsuka et al (2016) clarified that due to the acceleration of dissolution at the interface, the delamination life of the HA coating immersed in the simulated body fluid (SBF) is shortened. Therefore, the delamination behavior of FIGURE 1 | Surface treatment methods with their advantages, disadvantages, and applications (Vahabzadeh et al, 2015;Asri et al, 2017;Azari et al, 2019;Chouirfa et al, 2019;Kaur and Singh, 2019;Souza et al, 2019;Thangavel et al, 2019;Youn et al, 2019;Xia et al, 2020). extracorporeal circulation should be considered to extend the service life of HA coatings.…”

Section: Plasma Spray Technologymentioning

confidence: 99%

See 1 more Smart Citation

Surface Modification Techniques of Titanium and its Alloys to Functionally Optimize Their Biomedical Properties: Thematic Review

Xue

Attarilar

Liu

et al. 2020

Front. Bioeng. Biotechnol.

145

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Depending on the requirements of specific applications, implanted materials including metals, ceramics, and polymers have been used in various disciplines of medicine. Titanium and its alloys as implant materials play a critical role in the orthopedic and dental procedures. However, they still require the utilization of surface modification technologies to not only achieve the robust osteointegration but also to increase the antibacterial properties, which can avoid the implant-related infections. This article aims to provide a summary of the latest advances in surface modification techniques, of titanium and its alloys, specifically in biomedical applications. These surface techniques include plasma spray, physical vapor deposition, sol-gel, micro-arc oxidation, etc. Moreover, the microstructure evolution is comprehensively discussed, which is followed by enhanced mechanical properties, osseointegration, antibacterial properties, and clinical outcomes. Future researches should focus on the combination of multiple methods or improving the structure and composition of the composite coating to further enhance the coating performance.

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Section: Plasma Spray Technologymentioning

confidence: 99%

“…Besides, Hauschild et al (2015) put the Ag-coated cementless stem into the canine model and showed osseous integration in vivo, where toxic side effects did not appear. Afterward, Ag-doped NiTi (NiTi/Ag) coatings were prepared on pure Ti substrates by Thangavel et al (2019). The NiTi/Ag coating with 3 at.…”

Section: Physical Vapor Depositionmentioning

confidence: 99%

Surface Modification Techniques of Titanium and its Alloys to Functionally Optimize Their Biomedical Properties: Thematic Review

Xue

Attarilar

Liu

et al. 2020

Front. Bioeng. Biotechnol.

145

View full text Add to dashboard Cite

show abstract

“…In addition to the antibacterial, antitumor, and osseointegration capabilities of titanium implants—which are the most important in the field of orthopedics—the better biocompatibility of titanium implants is also an indispensable characteristic. RF magnetron sputtering, plasma spraying, and other technologies also play an important role in the preparation of titanium implants; in some reports, achievements have also been made in enhancing the biocompatibility of titanium implants [ 123 , 124 , 125 , 126 ]. In summary, in orthopedic clinics, in order to meet the needs of orthopedics, the processed titanium-based implants should have good physical properties, including elastic modulus, fatigue resistance, etc.…”

Section: Discussionmentioning

confidence: 99%

Titanium Implants and Local Drug Delivery Systems Become Mutual Promoters in Orthopedic Clinics

Gao

Zhao

et al. 2021

Nanomaterials

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Titanium implants have always been regarded as one of the gold standard treatments for orthopedic applications, but they still face challenges such as pain, bacterial infections, insufficient osseointegration, immune rejection, and difficulty in personalizing treatment in the clinic. These challenges may lead to the patients having to undergo a painful second operation, along with increased economic burden, but the use of drugs is actively solving these problems. The use of systemic drug delivery systems through oral, intravenous, and intramuscular injection of various drugs with different pharmacological properties has effectively reduced the levels of inflammation, lowered the risk of endophytic bacterial infection, and regulated the progress of bone tumor cells, processing and regulating the balance of bone metabolism around the titanium implants. However, due to the limitations of systemic drug delivery systems—such as pharmacokinetics, and the characteristics of bone tissue in the event of different forms of trauma or disease—sometimes the expected effect cannot be achieved. Meanwhile, titanium implants loaded with drugs for local administration have gradually attracted the attention of many researchers. This article reviews the latest developments in local drug delivery systems in recent years, detailing how various types of drugs cooperate with titanium implants to enhance antibacterial, antitumor, and osseointegration effects. Additionally, we summarize the improved technology of titanium implants for drug loading and the control of drug release, along with molecular mechanisms of bone regeneration and vascularization. Finally, we lay out some future prospects in this field.

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“…In terms of using TiNi–Ag materials in the medical industry, alloying TiNi with Ag provides the alloy with new attributes suitable for biomedical applications, improving its cytocompatibility and antibacterial capacity [ 11 ], while increasing yield and tensile strengths [ 16 , 17 ]. TiNi composite surface films doped with silver (4–10 at.%) enhance mechanical strength, biocompatibility, and corrosion resistance to implants [ 18 , 19 , 20 ]. However, as the silver concentration exceeds 5 at.%, the antibacterial properties of the alloy deteriorate.…”

Section: Introductionmentioning

confidence: 99%

Influence of Silver Addition on Structure, Martensite Transformations and Mechanical Properties of TiNi–Ag Alloy Wires for Biomedical Application

et al. 2020

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The microstructural and functional behavior of TiNi-based wires with a silver content of 0–1.5 at.% was evaluated. The concentration range for Ag doping determined for the TiNi wires with potential for the medical industry was 0–0.2 at.%. Microstructure analysis of TiNi wires with different silver contents at room temperature indicated a multiphase structural state. Various internal structures with tangled grain boundaries were formed by intense plastic deformation. The nanocrystalline structure and phase state of wire with the minimum silver content (0.1 at.% Ag) provide full shape recovery, the greatest reversible strain, and optimal strength and ductility. TiNi ingots with a high Ag content (0.5–1.5 at.%) cracked under minimum load due to excess silver that crystallized along the grain boundaries and broke cohesion bonds between the TiNi grains.

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RF magnetron sputtering mediated NiTi/Ag coating on Ti-alloy substrate with enhanced biocompatibility and durability

Cited by 22 publications

References 44 publications

Surface Modification Techniques of Titanium and its Alloys to Functionally Optimize Their Biomedical Properties: Thematic Review

Surface Modification Techniques of Titanium and its Alloys to Functionally Optimize Their Biomedical Properties: Thematic Review

Titanium Implants and Local Drug Delivery Systems Become Mutual Promoters in Orthopedic Clinics

Influence of Silver Addition on Structure, Martensite Transformations and Mechanical Properties of TiNi–Ag Alloy Wires for Biomedical Application

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