2012
DOI: 10.1016/j.mod.2012.07.004
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Rgs19 regulates mouse palatal fusion by modulating cell proliferation and apoptosis in the MEE

Abstract: Palatal development is one of the critical events in craniofacial morphogenesis. During fusion of the palatal shelves, removal of the midline epithelial seam (MES) is a fundamental process for achieving proper morphogenesis of the palate. The reported mechanisms for removing the MES are the processes of apoptosis, migration or general epithelial-to-mesenchymal transition (EMT) through modulations of various signaling molecules including Wnt signaling. RGS19, a regulator of the G protein signaling (RGS) family,… Show more

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Cited by 13 publications
(10 citation statements)
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References 41 publications
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“…Histochemical staining was carried out as described (Sohn et al ., 2012). Adjacent sections were used for immunohistochemistry.…”
Section: Methodsmentioning
confidence: 99%
“…Histochemical staining was carried out as described (Sohn et al ., 2012). Adjacent sections were used for immunohistochemistry.…”
Section: Methodsmentioning
confidence: 99%
“…This would tend to suppress Gα i3 activity, but potentiate Gβγ signaling. The results of targeting Rgs19 in mice have not been reported, however knocking down Rgs19 expression during mouse development suggested that Rgs19 functions to limit the expression of Wnt-responsive genes, which are needed for proper midline fusion of the mouse palate (144). …”
Section: G-protein Regulatory Proteinsmentioning
confidence: 99%
“…The eventual result of this morphogenetic movement and tissue fusion is the formation of an oral cavity below the palate and a nasal cavity above the palate. Epithelial cells in the regions of contact between the paired palatal processes (the MEE) are removed through a combination of processes primarily involving apoptosis (Cuervo et al, 2002; Sohn et al, 2012), and cell migration (Martinez-Alvarez et al, 2000). A more recent study, using a combination of live imaging, genetic fate mapping, and gene ablation studies posited a “convergence and extrusion” mechanism to delineate the critical events occurring during MES dissolution (Kim et al, 2015).…”
Section: Introductionmentioning
confidence: 99%