Rho (Du) Testing with Anti‐Rho‘“(CDE) Reagents

Schmidt, Paul; Morrison, Eleanor; Solomon, Joel

doi:10.1111/j.1423-0410.1963.tb03300.x

Vox Sanguinis

1963

DOI: 10.1111/j.1423-0410.1963.tb03300.x

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Rh_o (D^u) Testing with Anti‐Rh_o‘“(CDE) Reagents

Paul Schmidt

Eleanor Morrison

Joel Solomon

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Cited by 3 publications

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The Rh_o Variant — D^u

Sturgeon

1962

Transfusion

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In a survey of 18,365 bloods for the incidence of the Du factor, in a population comprised approximately of 72 per cent Caucasoids, 15 per cent Negroids, 10 per cent Mexicans and 3 per cent Orientals, 78 Du bloods were found of which seven were type ccDuee. Of the latter, five came from Negroids and two from Caucasoids; the frequency among the two populations approximates respectively one in 6,000 and one in 500. In the general population of this region it is one in 2,500. The degree of reactivity of the type ccDuee found in this study was that of the “low grade” variety. However, from the remaining 71 “low grade” Du bloods, substantially weaker examples were found among type CcDuee and ccDuEe. The indirect antiglobulin and ficinized cell method readily detected type ccDuee; however, among the weaker variants, the antiglobulin method gave the more consistent results. It is concluded, therefore, that type ccDuee does occur in this area with a frequency that is considered significant and that its detection rests on the antiglobulin or other equally sensitive methods.

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The Rh_o Variant — D^u

Sturgeon

1962

Transfusion

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Sources of Error in a Hospital Blood Bank

Schmidt

Kevy

1963

Transfusion

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An analysis has been made 0.' the 12 technical and 52 clerical errors occurring in a hospital blood bank over a 21-month period during which 5,806 transfusions were given. All but four of these errors were discovered before blood was transfused and no clinical complications resulted. In some cases, discovery of the error was quite fortuitous but the role of clinically oriented laboratory persmnel in recognizing unusual situations is stressed. Specific corrective measures are described and it is urged that a workable plan of reducing errors can only be achieved in each blood bank by an analysis based on past experience of the clinical effects oC its own operation.

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The Rh_o Variant‐D^u

et al. 1964

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A simplified test for the Du factor employing a reagent containing 25 per cent serum albumin, the “stick” technic to introduce cells and forceful cen‐trifugation has been given an extensive trial in a routine blood bank operation. A routine preliminary test with anti‐D gave 5,051 negative reactions among 26,753 bloods tested. The Du tube test was then performed on the former with an anti‐CDE reagent in parallel with the indirect antiglobulin test done with anti‐D. All bloods positive by one or both tests were tested further for D antigens by an anti‐D elution technic; they were also tested for Rh‐Hr factors. Among the 126 bloods positive by elution for the Dufactor, 122 and 126 were positive respectively by the antiglobulin and the Du tube tests. The two tests were in agreement on all eight of the type ccDuee bloods found in the study. The Dutube test, as done with anti‐CDE, gave no false negative reactions. It is, thus, concluded that bloods which are negative with this test will be type ccddee and can be labeled “Rh negative tested for Du. Serological factors which might account for sensitivity of the Du tube test's being the equal of the antiglobulin test are considered, as are the probabilities of the existence of D variants so weak that they could not be detected by either test.

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Rh_o (D^u) Testing with Anti‐Rh_o‘“(CDE) Reagents

Cited by 3 publications

References 5 publications

The Rh_o Variant — D^u

The Rh_o Variant — D^u

Sources of Error in a Hospital Blood Bank

The Rh_o Variant‐D^u

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Rho (Du) Testing with Anti‐Rho‘“(CDE) Reagents

Cited by 3 publications

References 5 publications

The Rho Variant — Du

The Rho Variant — Du

Sources of Error in a Hospital Blood Bank

The Rho Variant‐Du

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Product

Resources

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Rh_o (D^u) Testing with Anti‐Rh_o‘“(CDE) Reagents

The Rh_o Variant — D^u

The Rh_o Variant — D^u

The Rh_o Variant‐D^u