Rhabdomyolysis in Earthquake Victims in Nepal

Nepali, Rabin; Sigdel, Mahesh Raj; Shah, Dibya Singh

doi:10.1016/j.ekir.2016.11.009

Cited by 5 publications

(3 citation statements)

References 17 publications

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“…In humans crush injury often results from earthquakes, exposure to explosions, e.g. bombing campaigns, and it can also be a consequence of drug overuse, intensive exercise, etc ( Atef-Zafarmand and Fadem, 2003 ; Hampel et al, 1983 ; Nepali et al, 2017 ; Sinert et al, 1994 ; Su et al, 2009 ). A distinctive feature of rhabdomyolysis is that patients who survive the initial mechanical trauma and begin to heal then succumb to kidney failure some days later.…”

Section: Evidence That the Oxyferryl Radical Cation Is Formed ...mentioning

confidence: 99%

The peroxidatic activities of Myoglobin and Hemoglobin, their pathological consequences and possible medical interventions

Wilson

Reeder

2022

Molecular Aspects of Medicine

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Section: Evidence That the Oxyferryl Radical Cation Is Formed ...mentioning

confidence: 99%

The peroxidatic activities of Myoglobin and Hemoglobin, their pathological consequences and possible medical interventions

Wilson

Reeder

2022

Molecular Aspects of Medicine

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“…AKI can occur not solely through rhabdomyolysis, but also by means of sepsis, dehydration, and nephrotoxic agents. Mortality in rhabdomyolysis is generally associated with hyperkalemia in the acute period but with kidney failure and sepsis in subsequent periods [2]. Various electrolyte disturbances are observed post-rhabdomyolysis, such as hyperkalemia, hyperpotassemia, and hypokalemia.…”

Section: Introductionmentioning

confidence: 99%

Traumatic rhabdomyolysis: Electrolyte changes

Bicakcioglu

2023

Med-Science

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Severe electrolyte disturbances occur in traumatic rhabdomyolysis (crush syndrome) developing after disasters such as earthquakes. The purpose of this study is to examine the long-term course of these electrolyte abnormalities. Patients followed up in intensive care for at least 10 days due to post-earthquake crush syndrome were included in the study. Their demographic data and sodium, potassium, calcium, and phosphorus levels over the course of 10 days were retrieved retrospectively and recorded. Fifteen out of 23 patients with crush syndrome were enrolled in the study. The dominant electrolyte abnormalities in the first three days of hospitalization were normonatremia, hyperpotassemia, hypocalcemia, and hyperphosphatemia. No change in normonatremia was observed at the end of the 10th day, but hyperpotassemia gave way to normo- and hypokalemia, and hyperphosphatemia to normophosphatemia. Although hypocalcemia was less prevalent and not as deep as in the first five days, it was still the dominant calcium disorder at the end of the 10th day. Crush syndrome can be linked to severe electrolyte abnormalities. These electrolytes may be hypo or hyper in form at the onset of crush syndrome but can reverse in the opposite direction, or an existing abnormality may become more profound during follow-up. Knowing the direction assumed by electrolyte abnormalities, and on which days, will therefore be more beneficial for patient management.

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“…17 It has been documented that the requirement of dialysis supports due to septic AKI can reach as high as 20%. 18 Although there are few studies done in Nepal on septic AKI 19,20 and few case series and reports of rhabdomyolysis induced AKI, 21,22 there is a paucity of information on comparison between the clinical manifestations and outcomes of rhabdomyolysis induced acute kidney injury and septic AKI. So, this study was conducted with an aim to find out the etiologies, severity, biochemical changes, clinical course and prognosis of rhabdomyolysis induced AKI (RM-AKI) and compare it with sepsis associated AKI (SA-AKI) among hospitalized patients.…”

Section: Introductionmentioning

confidence: 99%

Comparison between Rhabdomyolysis Induced and Septic Acute Kidney Injury in Central Nepal

et al. 2019

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Background: Acute kidney injury (AKI) is one of the most serious complications of rhabdomyolysis (RM). We studied the clinical manifestations and prognosis of rhabdomyolysis induced AKI and compared it with septic AKI among hospitalized patients. Methods: A prospective study was conducted at Chitwan Medical College between January 2017 to June 2018 to compare AKI secondary to rhabdomyolysis (RM-AKI) and sepsis (SA-AKI). AKI was diagnosed as per Kidney Disease Improving Global Outcomes (KDIGO) 2012 guidelines. Rhabdomyolysis was diagnosed if serum creatinine phosphokinase raised >5 times the upper limit of normal level and sepsis as an increase of two or more points in the Sequential Organ failure Assessment (SOFA) score with the evidence of infection. Results: A total of 145 patients with AKI (21 with RM and 124 with sepsis) were included in the study. Mean age of the patients was 43.7 years with majority (54%) being males. Wasp bite and bee sting combined together (47.6%) were the most common causes for RM-AKI whereas pneumonia accounted for 46.6% of the septic AKI. Serum creatinine (SCr) at admission and at discharge were 3.8 and 1.4 mg/dL respectively in RM-AKI group; and 2.4 and 1.6 mg/dL in septic AKI group. Duration of stays in the hospital (9.2 versus 6.4 days) and ICU (4.2 versus 3.7 days) were longer in RM than in septic AKI. In hospital mortality was 4.8% in RM and 8.9% in septic AKI. Conclusions: This study has found that, despite a longer duration of hospital stay, RM-AKI had a lower in-hospital mortality than septic AKI.

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Rhabdomyolysis in Earthquake Victims in Nepal

Cited by 5 publications

References 17 publications

The peroxidatic activities of Myoglobin and Hemoglobin, their pathological consequences and possible medical interventions

The peroxidatic activities of Myoglobin and Hemoglobin, their pathological consequences and possible medical interventions

Traumatic rhabdomyolysis: Electrolyte changes

Comparison between Rhabdomyolysis Induced and Septic Acute Kidney Injury in Central Nepal

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