Rhadinovirus Pathogenesis

Ensser, Armin; Neipel, Frank; Fickenscher, Helmut

doi:10.1007/0-306-47650-9_13

Cited by 3 publications

(4 citation statements)

References 409 publications

(519 reference statements)

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“…The HVS-transformed T cell lines resemble activated mature CD4 + or CD8 + T cells, and mostly remain dependent on exogenous IL-2. Remarkably, HVS-transformed human T cells retain the antigen specificity of their parental cell clones (reviewed in Ensser et al, 2002). The strain C488 has been used most frequently for this application, and a few other subgroup C strains such as C484 and C139 have also been reported to be capable of transforming primary human T cells, although apparently less efficiently (Medveczky et al, 1993;Fickenscher et al, 1997).…”

Section: Commentary Background Informationmentioning

confidence: 99%

“…Remarkably, HVS-transformed human T cells retain the antigen specificity of their parental cell clones (reviewed in Ensser et al, 2002).…”

Section: Commentary Background Informationmentioning

confidence: 99%

“…Although some lines may display morphologic and cellsurface changes, they generally respond to stimulation via the specific antigen, anti-CD3, anti-CD2, or mitogens Furthermore, they become constitutive producers of certain lymphokines. Additional information concerning HVS-transformed T cells can be found in the detailed reviews of HVS by Fickenscher and Fleckenstein (2001) and Ensser et al (2002).…”

Section: Commentary Background Informationmentioning

confidence: 99%

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Herpesvirus saimiri Transformation of Human T Lymphocytes

Fleckenstein

Ensser

2004

CP in Immunology

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Viral transformation of T cells is an effective method for obtaining large numbers of T cells that are easily maintained in the laboratory. This unit describes a method for generating antigen-independent, virally-transformed T cells using a T-lymphotropic primate gamma-2 herpesvirus, Herpesvirus saimiri (HVS; strain C488). Support protocols for preparing and titrating HSV C488 stocks and testing the functional status of transformed T cells are also included.

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Section: Commentary Background Informationmentioning

confidence: 99%

“…Remarkably, HVS-transformed human T cells retain the antigen specificity of their parental cell clones (reviewed in Ensser et al, 2002).…”

Section: Commentary Background Informationmentioning

confidence: 99%

Section: Commentary Background Informationmentioning

confidence: 99%

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Herpesvirus saimiri Transformation of Human T Lymphocytes

Fleckenstein

Ensser

2004

CP in Immunology

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“…Therefore, our finding indicates the possibility of cross-species transmission from other deer reservoirs to the Formosan sambar deer. Like other herpesviruses, it is possible that RuRvs could be pathogenic to certain species or under certain conditions [ 2 ]. The Formosan sambar deer is currently the only endemic Cervinae species in the region where the infected deer was discovered ( Fig.…”

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confidence: 99%

Encephalitis induced by a newly discovered ruminant rhadinovirus in a free-living Formosan sambar deer (<i>Rusa unicolor swinhoei</i>)

Chang

Chen

Chang

et al. 2018

The Journal of Veterinary Medical Science

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We documented a case of a free-living Formosan sambar deer (Rusa unicolor swinhoei) infected with a newly discovered ruminant Rhadinovirus (RuRv). Non-purulent encephalitis was the primary histological lesion of the sambar deer. We conducted nested PCR to screen for herpesvirus using generic primers targeting the DNA polymerase gene. In addition, we found that DNA polymerase gene of the sambar deer RuRv was present in the macrophage distributed in the Virchow Robin space with histopathologic lesions by chromogenic in-situ hybridization (CISH). The phylogenetic analysis indicated a high similarity between the viral sequence isolated from fallow deer and our case. This result suggests the possibility of cross-species transmission from other exotic Cervidae reservoir to the Formosan sambar deer.

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Transformation by Herpesviruses: Focus on T Cells

Ensser

2005

Future Virol.

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Acute T-lymphoproliferative syndromes are caused by herpesvirus saimiri (HVS) and ateles in neotropical primates; by alcelaphine herpesvirus-1 and ovine herpesvirus-2 strains in domestic cattle and other ungulates; and by the α-herpesvirus of Marek's disease in chickens. T-cell lymphoproliferation caused by these herpesviruses has short incubation periods and a rapid course when compared with retroviral disease. The B-lymphotropic Epstein–Barr virus (EBV) is also associated with some human T-cell malignancies. Analogous to EBV in B cells, HVS isolates of the subgroup C are uniquely capable of transforming human and Old World primate T lymphocytes to continuous growth in cell culture and can provide useful tools for T-cell immunology or gene transfer. Signal transduction pathways stimulated by the viral oncoproteins seem to converge at related cellular effector proteins, in total providing a proproliferative signal. However, the viral oncoproteins most likely evolved to evade immune recognition and to support persistent infection in the natural host, where these viruses are frequently apathogenic.

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Rhadinovirus Pathogenesis

Cited by 3 publications

References 409 publications

Herpesvirus saimiri Transformation of Human T Lymphocytes

Herpesvirus saimiri Transformation of Human T Lymphocytes

Encephalitis induced by a newly discovered ruminant rhadinovirus in a free-living Formosan sambar deer (<i>Rusa unicolor swinhoei</i>)

Transformation by Herpesviruses: Focus on T Cells

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