Rhamnan sulphate from Monostroma nitidum attenuates hepatic steatosis by suppressing lipogenesis in a diet-induced obesity zebrafish model

Zang, Liqing; Tanaka, Toshio

doi:10.1016/j.jff.2015.05.041

Cited by 38 publications

(32 citation statements)

References 32 publications

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“…Due to the high similarity to mammals in organ physiology and metabolism along with the less labor intensity, zebrafish (Danio rerio) has been considered to be favorable animal to explore diabetes and its related diseases, being a favorable alternative to rodent. 23,24 Recently Zang et al developed a novel zebrafish model for type 2 diabetes mellitus, which was considered to be a promising platform for mechanic and therapeutic studies of diet-induced glucose intolerance and insulin resistance. 25 In the present work, the omics analysis for phospholipids and oxidized phospholipids was performed to investigate the characteristics in the plasma from diabetic zebrafish.…”

Section: Introductionmentioning

confidence: 99%

Lipidomic Profiling on Oxidized Phospholipids in Type 2 Diabetes Mellitus Model Zebrafish

Chen

Zang

et al. 2018

ANAL. SCI.

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Type 2 diabetes mellitus is a serious metabolic disorder in the world. Oxidative stress, as a key role on the pathogenesis of diabetes, also results in the oxidation of phospholipids. However, studies on phospholipid oxidation in diabetes, especially directly focusing on oxidized and degraded phospholipid species, are quite limited. In this study, phospholipid profiles of diabetic zebrafish plasma were characterized by LC-HRMS and MS/MS, and the total amounts of each lipid class were compared. Furthermore, the key molecular species as biomarkers in distinguishing control and diabetic samples were investigated by orthogonal partial least squares discriminant analysis. Among the identified 114 phospholipid species in total, there were 11 hydroperoxides, 7 aldehydes, and 19 lysophospholipids found significantly elevated along with the increasing blood glucose, which were known as oxidation or degradation products. Furthermore, lysophosphatidylcholine 20:5 and lysophosphatidylcholine 22:6 were assessed as potential biomarkers in diabetic zebrafish. The current work would not only help to gain further insights into diabetes, but also contribute to find new clinical parameters for the screening of the promising antioxidant agents for its therapies.

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Section: Introductionmentioning

confidence: 99%

Lipidomic Profiling on Oxidized Phospholipids in Type 2 Diabetes Mellitus Model Zebrafish

Chen

Zang

et al. 2018

ANAL. SCI.

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“…RS has been reported to have biological activities such as antiviral [6,[9][10][11][12][13], anticoagulant [14][15][16][17][18][19][20][21], and antitumor [22] activities. It also induces hyaluronidase inhibition [23], exhibits anti-hypercholesterolemic effect [24,25] suppresses blood glucose elevation [26], and helps with weight control [25]; thus, M. nitidum-derived RS is considered to be involved in many activities in host defense of humans. Table 1 is a summary of the biological activities of RS reported to date.…”

Section: Biological Activities Of Rsmentioning

confidence: 99%

“…Anti-hyaluronidase in vitro study [23] Antitumor in vitro study [22] Anti-obesity in vivo study [25] Anti-thrombosis in vitro study [14][15][16][17][18][19][20][21], in vivo study [16,17] Antivirus in vitro study [6,[9][10][11]13], in vivo study [12,13] Anti-hypercholesterolemia in vivo study [25], human trial [24] Anti-hyperglycemia in vivo study [26], human trial [26] In what follows, we describe some of the biological activities of M. nitidum-derived RS that we have studied and reported, especially its antiviral, anti-obesity, anti-hypercholesterolemic, anti-glycemia, antithrombotic, and anti-inflammation effects.…”

Section: Biological Activity Of Rs Referencesmentioning

confidence: 99%

Biological Activities of Rhamnan Sulfate Extract from the Green Algae Monostroma nitidum (Hitoegusa)

Suzuki

Terasawa

2020

Marine Drugs

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Monostroma nitidum is a green single-cell layered algae that grows on the southwest coast of Japan. It is often used for salad ingredients, boiled tsukudani, soups, etc., due to its health benefits. M. nitidum is composed of many cell aggregates, and the various substances that fill the intercellular space are dietary fibers, vitamins, and minerals. Rhamnan sulfate (RS), a sulfated polysaccharide, is main the component of the fiber extracted from M. nitidum. Recently, some biological properties of RS have been demonstrated by in vitro and in vivo studies that probably protect human subjects from viruses and ameliorate vascular dysfunction caused by metabolic disorders, especially lifestyle-related diseases. In this review, we focus on the antithrombotic effects of RS and introduce its antiviral and other biological activities.

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“…Monostroma nitidum (M. nitidum) is a green alga that grows in shallow waters along the coasts of Japan. Rhamnan sulfate (RS) is another sulfated polysaccharide found in green seaweed [8], and it has recently been identified as a main component of M. nitidum [8,9]. The main repeating unit of RS consists of rhamnose with a sulfate-group substituent that forms long linear chains with branched side chains [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

“…The main repeating unit of RS consists of rhamnose with a sulfate-group substituent that forms long linear chains with branched side chains [10][11][12]. Several in vitro and in vivo studies have reported that RS has anticoagulative [12][13][14][15][16][17], antiviral [10,[18][19][20], anti-inflammatory [21], and anti-obesity properties [9].…”

Section: Introductionmentioning

confidence: 99%

Anti-Influenza A Virus Activity of Rhamnan Sulfate from Green Algae Monostroma nitidum in Mice with Normal and Compromised Immunity

et al. 2020

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Influenza viruses cause a significant public health burden each year despite the availability of anti-influenza drugs and vaccines. Therefore, new anti-influenza virus agents are needed. Rhamnan sulfate (RS) is a sulfated polysaccharide derived from the green alga Monostroma nitidum. Here, we aimed to demonstrate the antiviral activity of RS, especially against influenza A virus (IFV) infection, in vitro and in vivo. RS showed inhibitory effects on viral proliferation of enveloped viruses in vitro. Evaluation of the anti-IFV activity of RS in vitro showed that it inhibited both virus adsorption and entry steps. The oral administration of RS in IFV-infected immunocompetent and immunocompromised mice suppressed viral proliferation in both mouse types. The oral administration of RS also had stimulatory effects on neutralizing antibody production. Fluorescent analysis showed that RS colocalized with M cells in Peyer's patches, suggesting that RS bound to the M cells and may be incorporated into the Peyer's patches, which are essential to intestinal immunity. In summary, RS inhibits influenza virus infection and promotes antibody production, suggesting that RS is a potential candidate for the treatment of influenza virus infections.

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Rhamnan sulphate from Monostroma nitidum attenuates hepatic steatosis by suppressing lipogenesis in a diet-induced obesity zebrafish model

Cited by 38 publications

References 32 publications

Lipidomic Profiling on Oxidized Phospholipids in Type 2 Diabetes Mellitus Model Zebrafish

Lipidomic Profiling on Oxidized Phospholipids in Type 2 Diabetes Mellitus Model Zebrafish

Biological Activities of Rhamnan Sulfate Extract from the Green Algae Monostroma nitidum (Hitoegusa)

Anti-Influenza A Virus Activity of Rhamnan Sulfate from Green Algae Monostroma nitidum in Mice with Normal and Compromised Immunity

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