Rhapontigenin Converted from Rhapontin Purified from<i>Rheum undulatum</i>Enhances the Inhibition of Melanin Synthesis

Lee, Hyun Sun; Kim, Jeong Keun; Park, Keun Tae; Lim, Young Hee

doi:10.1271/bbb.120229

Cited by 5 publications

(1 citation statement)

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“…Rheum undulatum L. (R. undulatum), also known as rhubarb, is a well-established East-Asian traditional medicine for the treatment of inflammation (6,7), allergies (8), dental diseases (6) and blood stagnation (7,9). Previous studies also revealed that R. undulatum has numerous pharmacological effects, including hepatocyte protective (10), anti-obesity and hypolipidemic (7,11), anti-cariogenic (12), anti-allergic (8,9), tyrosinase inhibition (13), anti-diabetic (14), anti-platelet aggregation (15), anti-atherosclerotic (16) and anticancer (6,(17)(18)(19)(20) effects. Among the natural compounds of R. undulatum, stilbenes, a group of non-flavonoid phenolic compounds, are potential candidates for cancer chemoprevention (21).…”

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confidence: 99%

Stilbenes contribute to the anticancer effects of Rheum�undulatum L. through activation of apoptosis

et al. 2019

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Rheum undulatum L. (R. undulatum) is a medicinal plant used for the treatment of inflammatory diseases in East Asian countries. Numerous stilbenes isolated from R. undulatum have been revealed to possess anticancer effects. The aim of the present study was to evaluate the effect of extracts and compounds isolated from R. undulatum on human gastric cancer cell viability and to elucidate their molecular mechanism of action on the apoptosis pathway. The results demonstrated that aloe-emodin and chrysophanol 1-O-β-D-glucopyranoside, isolated from the methanolic extract of dried rhizomes of R. undulatum, exhibited anti-proliferative effects on the human gastric carcinoma cell line AGS, with IC 50 values of 84.66±0.44 and 68.28±0.29 µM, respectively. The percentage of apoptotic cells increased significantly following treatment with each compound at a concentration of 100 µM, compared with that in the non-treated group in the image-based cytometry assay. Western blot analysis revealed that these compounds activated the caspase cascade and inhibited B-cell lymphoma-2, an anti-apoptotic protein.

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