Rheological behavior of regenerated silk fibroin/polyvinyl alcohol blended solutions in steady and dynamic state and the effect of temperature

Zhang, Xin; Pan, Zhijuan

doi:10.1007/s10853-020-05086-4

Cited by 8 publications

(7 citation statements)

References 37 publications

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“…As expected, upon blending respective viscosities were falling in between that of pure components. Zhang and Pan also reported similar results in aqueous solutions of mulberry silk and PVA blend [11].…”

Section: Constant Shear Rheological Studies Of Silk Fibroin and Gelatin Blend Solutionssupporting

confidence: 53%

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Multifunctional Properties of Non-mulberry Silk Fibroin and Gelatin Blend Solutions: Rheological Study

Priti

Batra

Purwar

2021

Springer Proceedings in Materials

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In this work, we have studied the influence of blending Antheraea mylitta silk fibroin solution (concentration 10% w/v) with solution of gelatin (concentration 20% w/v) by using 99% pure formic acid as a solvent. Various blends with desired ratios namely G0S10, G8S2, G7S3, G5S5, and G10S0 were prepared and studied for their viscoelastic behavior. The time dependent analysis with respect to change in viscosity which is also termed as constant shear rate viscosity study was performed for all the blend solutions. Behavior of the pure and blend solutions in the applied range of shear rates viz., 0.01-500 s −1 were also studied. Under dynamic rheological tests, amplitude sweep and frequency sweep were executed. In viscosity test results, a decrease in viscosity was observed in blends of gelatin and silk fibroin as compared to pure silk fibroin solution. Shear thinning behavior was observed in all the blend solutions in the applied shear range. Through amplitude sweep analysis of the blend solutions further, frequency sweep study was carried out by applying a definite percent strain. It can be confirmed through these rheological studies by changing the operating parameters like shear rate, angular frequency, and blend ratios, etc., the properties of blend solutions can be tuned according to the desired end use applications such as medical, textile, tissue engineering, and packaging, etc.

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Section: Constant Shear Rheological Studies Of Silk Fibroin and Gelatin Blend Solutionssupporting

confidence: 53%

“…However, the properties of blend solutions which can impact the final product properties have not been emphasized much. A hand full of reports are available on rheological studies of silk fibroin blend solutions, and majorly mulberry silk is the variety used for the study [10,11].…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Properties of Non-mulberry Silk Fibroin and Gelatin Blend Solutions: Rheological Study

Priti

Batra

Purwar

2021

Springer Proceedings in Materials

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“…Figure 3 shows the steady-state and dynamic-state rheological test results of RRSF/PVA/TiO 2 blended solutions. In previous studies, the rheological behavior and spinnability of RRSF/PVA blended spinning solutions have been thoroughly studied, 41 and RRSF/PVA fibers have been prepared continuously and stably. 38 Therefore, rheological data of RRSF/PVA solutions have been used as a standard to explore the influence of TiO 2 on the rheological behavior of solutions.…”

Section: Resultsmentioning

confidence: 99%

Sustainable Antibacterial Surgical Suture Based on Recycled Silk Resource by an Internal Combination of Inorganic Nanomaterials

Zhang

Yang

et al. 2023

ACS Appl. Mater. Interfaces

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The current antibacterial treatment methods of silk sutures can only be finished by surface modification, leading to problems of short antibacterial effects, easy slow-release consumption, prominent toxicity, and susceptibility to drug resistance. Speculatively, surgical sutures combining antibacterial material internally will possess a more promising efficacy. Hence, we extracted recycled regenerated silk fibroin (RRSF) from waste silk resources to make RRSF solutions. Internally combining with inorganic titanium dioxide (TiO2) nanoparticles, we fabricated antibacterial RRSF-based surgical sutures. The morphologies, mechanical and antibacterial properties, biocompatibility tests, and in vivo experiments were carried out. The results showed that the surgical sutures with 1.25 wt % TiO2 acquired 2.40 N knot strength (143 μm diameter) and achieved a sustainable antibacterial effect of 93.58%. Surprisingly, the sutures significantly reduced inflammatory reactions and promoted wound healing. Surgical sutures in this paper realize high-value recovery of waste silk fibers and provide a novel approach to preparing multifunctional sutures.

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“…The dependence of viscosity on frequency dramatically decreases until the solutions display a Newtonian behavior in a high-shear rate regime, indicating a flowing alignment of the underlying microstructure . The rheological behavior of PVA aqueous solutions is determined by the concentration of PVA and the strength and number of hydrogen bonds, including intrachain, interchain, and PVA–H 2 O hydrogen bonds …”

Section: Results and Discussionmentioning

confidence: 99%

“…45 The rheological behavior of PVA aqueous solutions is determined by the concentration of PVA and the strength and number of hydrogen bonds, including intrachain, interchain, and PVA− H 2 O hydrogen bonds. 46 The SF and PVA Microneedles' Preparation and Characterization. The microneedles obtained from PVA and SF blend solutions (SF methanol, SF, SF 7:3 PVA, SF 1:1 PVA, SF 3:7 PVA, and PVA) were prepared by a straightforward two-step casting method.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Silk Fibroin/Poly(vinyl Alcohol) Microneedles as Carriers for the Delivery of Singlet Oxygen Photosensitizers

Rojas

Oliveira

Araújo

et al. 2021

ACS Biomater. Sci. Eng.

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Photodynamic therapy (PDT) is a medical treatment in which a combination of a photosensitizing drug and visible light produces highly cytotoxic reactive oxygen species (ROS) that leads to cell death. One of the main drawbacks of PDT for topical treatments is the limited skin penetration of some photosensitizers commonly used in this therapy. In this study, we propose the use of polymeric microneedles (MNs) prepared from silk fibroin and poly(vinyl alcohol) (PVA) to increase the penetration efficiency of porphyrin as possible applications in photodynamic therapy. The microneedle arrays were fabricated from mixtures in different proportions (1:0, 7:3, 1:1, 3:7, and 0:1) of silk fibroin and PVA solutions (7%); the polymer solutions were cast in polydimethylsiloxane (PDMS) molds and dried overnight. Patches containing grids of 10 × 10 microneedles with a square-based pyramidal shape were successfully produced through this approach. The polymer microneedle arrays showed good mechanical strength under compression force and sufficient insertion depth in both Parafilm M and excised porcine skin at different application forces (5, 20, 30, and 40 N) using a commercial applicator. We observe an increase in the cumulative permeation of 5-[4-(2-carboxyethanoyl) aminophenyl]-10,15,20-tris-(4-sulphonatophenyl) porphyrin trisodium through porcine skin treated with the polymer microneedles after 24 h. MNs may be a promising carrier for the transdermal delivery of photosensitizers for PDT, improving the permeation of photosensitizer molecules through the skin, thus improving the efficiency of this therapy for topical applications.

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Rheological behavior of regenerated silk fibroin/polyvinyl alcohol blended solutions in steady and dynamic state and the effect of temperature

Cited by 8 publications

References 37 publications

Multifunctional Properties of Non-mulberry Silk Fibroin and Gelatin Blend Solutions: Rheological Study

Multifunctional Properties of Non-mulberry Silk Fibroin and Gelatin Blend Solutions: Rheological Study

Sustainable Antibacterial Surgical Suture Based on Recycled Silk Resource by an Internal Combination of Inorganic Nanomaterials

Silk Fibroin/Poly(vinyl Alcohol) Microneedles as Carriers for the Delivery of Singlet Oxygen Photosensitizers

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