Rheological characteristics and diffusion processes in mixed cellulose hydrogel matrices

Michailova, Victoria; Titeva, St; Kotsilkova, Rumiana

doi:10.1016/s1773-2247(05)50086-8

Cited by 8 publications

(6 citation statements)

References 15 publications

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“…The hydrogels have been found to be suitable materials for controlled release drug delivery and tissue scaffolds. 42 The authors' earlier study of in situ crosslinked cellulose nanowhiskers with a hydrophilic matrix resulted in a hydrogel capable of taking up moisture as high as 900% of its original weight. These materials are potential applications for burn healing or controlled release of drugs.…”

Section: Medical Applicationsmentioning

confidence: 99%

Novel bionanocomposites: processing, properties and potential applications

Oksman

Mathew

Sain

2009

Plastics, Rubber and Composites

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The demand for environmental sustainability has resulted in a great interest in finding new materials that are biodegradable and environmentally friendly. Therefore, materials derived from natural resources are now being extensively studied. Preparation of novel biocomposites based on nanocelluloses has drawn specific attention. It is expected that cellulose nanocomposites will open new areas for applications in medicine, packaging, electronics, the automotive sector, construction and other areas. This article presents a new research field of bionanocomposites where different types of nanocelluloses are used as reinforcements in biopolymers. Isolation of cellulose nanofibres and nanowhiskers from different sources, and processing technologies for the composites, are described and discussed. The main difficulty when producing cellulose based nanocomposites is to disperse the reinforcement in the polymer matrix without degradation of the biopolymer or the reinforcing phase. This can be addressed by improving the interaction (compatibility) between nanofibres and the matrix and by using suitable processing methods. The study of alignment of the nanocelluloses by using magnetic field is discussed and the nanocomposites' mechanical properties, based on the findings from different studies, are presented. Finally, some examples of future nanocomposites are discussed.

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Section: Medical Applicationsmentioning

confidence: 99%

Novel bionanocomposites: processing, properties and potential applications

Oksman

Mathew

Sain

2009

Plastics, Rubber and Composites

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“…In the cited study, PVA (poly(vinyl) alcohol) and MC (methyl cellulose) were combined to make an interpenetrating polymeric network through crosslinking with epichlorohydrin. This spongy material can also serve as a way to host a drug and later release it (see Michailova et al 2005). In the cited study a mixed hydroxypropylmethyl cellulose and carboxymethyl cellulose hydrogel were used to measure the water penetration and drug release rates.…”

Section: Medical Applicationsmentioning

confidence: 99%

Cellulosic nanocomposites. A review

Hubbe

Rojas²,

Lucia³

et al. 2008

BioRes

680

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Because of their wide abundance, their renewable and environmentally benign nature, and their outstanding mechanical properties, a great deal of attention has been paid recently to cellulosic nanofibrillar structures as components in nanocomposites. A first major challenge has been to find efficient ways to liberate cellulosic fibrils from different source materials, including wood, agricultural residues, or bacterial cellulose. A second major challenge has involved the lack of compatibility of cellulosic surfaces with a variety of plastic materials. The water-swellable nature of cellulose, especially in its non-crystalline regions, also can be a concern in various composite materials. This review of recent work shows that considerable progress has been achieved in addressing these issues and that there is potential to use cellulosic nano-components in a wide range of high-tech applications.

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“…12 The study and measurement of variable rheological moduli can predict drug diffusion from the entangled polymeric matrix. 13 The approach is aimed at investigating and studying the stability of polymers under the linear visco-elastic regime that greatly impacts drug release from the systems. and reagents were purchased from commercial sources.…”

Section: Introductionmentioning

confidence: 99%

Impact of Carboxymethylation of Albizia procera Gum on Rheological Changes and Drug Release from Matrix Tablets

Mukherjee¹,

Sa²,

Khanam³

et al. 2022

IJDDT

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The use of carbohydrate polymers in pharmaceutical formulations as drug delivery carriers has gained significant interest from many perspectives. As an exudate of the Albizia tree, Albizia procera (Mimosaceae), a carbohydrate polymer, is used as an excipient to develop sustained-release drug delivery systems, owing to its biocompatibility and biodegradability. This study was conducted to investigate the influence of carboxymethylation of A. procera gum on rheological properties and drug release from the matrix tablet formulations. The study also revealed the comparative characterization of the native form of A. procera (NAP) as well as the carboxymethylated A. procera (CMAP). The rheological assessments of both polymers under different pH divulged the flow behavior, linear viscoelasticity (LVE), structural deformation, and gel network formation. The drug release from NAP and CMAP matrices of various formulations were evaluated and established correlations with rheology.

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Rheological characteristics and diffusion processes in mixed cellulose hydrogel matrices

Cited by 8 publications

References 15 publications

Novel bionanocomposites: processing, properties and potential applications

Novel bionanocomposites: processing, properties and potential applications

Cellulosic nanocomposites. A review

Impact of Carboxymethylation of Albizia procera Gum on Rheological Changes and Drug Release from Matrix Tablets

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