Rheological properties of concentrated aqueous injectable calcium phosphate cement slurry

Liu, Changsheng; Shao, Huifang; Chen, Feiyue; Zheng, Hongming

doi:10.1016/j.biomaterials.2006.05.043

Cited by 111 publications

(70 citation statements)

References 35 publications

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“…The profiles we detected are also comparable to those presented by others, 46 particularly the similar values of G′ and G″ for PMMA bone cement. 47 …”

Section: Materials Properties Of Bone Cementsmentioning

confidence: 99%

Antimicrobial activity of bone cements embedded with organic nanoparticles

Perni¹,

Thenault²,

Abdo³

et al. 2015

IJN

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Infections after orthopedic surgery are a very unwelcome outcome; despite the widespread use of antibiotics, their incidence can be as high as 10%. This risk is likely to increase as antibiotics are gradually losing efficacy as a result of bacterial resistance; therefore, novel antimicrobial approaches are required. Parabens are a class of compounds whose antimicrobial activity is employed in many cosmetic and pharmaceutical products. We developed propylparaben nanoparticles that are hydrophilic, thus expanding the applicability of parabens to aqueous systems. In this paper we assess the possibility of employing paraben nanoparticles as antimicrobial compound in bone cements. The nanoparticles were embedded in various types of bone cement (poly(methyl methacrylate) [PMMA], hydroxyapatite, and brushite) and the antimicrobial activity was determined against common causes of postorthopedic surgery infections such as: Staphylococcus aureus , methicillin-resistant S. aureus , Staphylococcus epidermidis , and Acinetobacter baumannii . Nanoparticles at concentrations as low as 1% w/w in brushite bone cement were capable of preventing pathogens growth, 5% w/w was needed for hydroxyapatite bone cement, while 7% w/w was required for PMMA bone cement. No detrimental effect was determined by the addition of paraben nanoparticles on bone cement compression strength and cytocompatibility. Our results demonstrate that paraben nanoparticles can be encapsulated in bone cement, providing concentration-dependent antimicrobial activity; furthermore, lower concentrations are needed in calcium phosphate (brushite and hydroxyapatite) than in acrylic (PMMA) bone cements. These nanoparticles are effective against a wide spectrum of bacteria, including those already resistant to the antibiotics routinely employed in orthopedic applications, such as gentamicin.

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“…The profiles we detected are also comparable to those presented by others, 46 particularly the similar values of G′ and G″ for PMMA bone cement. 47 …”

Section: Materials Properties Of Bone Cementsmentioning

confidence: 99%

Antimicrobial activity of bone cements embedded with organic nanoparticles

Perni¹,

Thenault²,

Abdo³

et al. 2015

IJN

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“…4,9,17,18 Although neither a specific explanation of their existence nor a definite mathematical method to analyze their influence has been proposed, 19 the spurs have generally been attributed to the breakdown of structure within the systems. It has been shown that a spur developed when montmorillonite suspensions underwent a sol-gel transition because of the addition of sodium chloride.…”

Section: Resultsmentioning

confidence: 99%

Effect of selected non-ionic surfactants on the flow behavior of aqueous veegum suspensions

Kennedy

2007

AAPS PharmSciTech

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The aim of this work was to investigate the influence of some non-ionic surfactants, Tween 80 and Brij 98, on the viscosity and flow behavior of a commercial montmorillonite clay, Veegum Granules. The effect of different concentrations of the surfactants on the shear stress-shear rate rheograms of hydrated concentrated clay suspensions was determined by shear viscometry. The addition of either surfactant increased the plastic viscosity and the yield stress of the suspensions. Furthermore, both surfactants altered the thixotropy of the suspensions to an extent that depended on both the surfactant concentration and the time of equilibration of the surfactant and Veegum. Brij 98 had a greater and more rapid effect. It is proposed that the surfactant polar head-groups anchor at the tetrahedral sheet surface, leaving the alkyl chains extending away from the edges and faces. Consequently, the alkyl chains undergo hydrophobic interactions that facilitate the association between the platelets and increase the physical structure within the suspension. Stereochemical differences between the polar groups may lead to differences in the way the surfactants associate with the tetrahedral sheet and hence their ultimate effect on the rheological behavior. There is a significant interaction between these surfactants and montmorillonite clays, and the rheological changes that occur could have a major impact on any pharmaceutical formulation that uses these ingredients.

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“…18 Briefly, TECP was synthesized by a solid-to-solid reaction between Ca phosphate and Ca carbonate at a temperature of 1500°C for 8 hours. Dicalcium phosphate dihydrate was prepared from ammonium hydrogen phosphate and Ca nitrate in the acidic environment.…”

Section: Preparation and Characterization Of Wnf-cpcmentioning

confidence: 99%

Wollastonite nanofiber–doped self-setting calcium phosphate bioactive cement for bone tissue regeneration

Guo¹,

Wei²,

Song³

et al. 2012

IJN

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Abstract:The purpose of this study was to synthesize a self-setting bioactive cement by incorporation of wollastonite nanofibers (WNFs) into calcium phosphate cement (CPC). The composition, morphology, setting time, compressive strength, hydrophilicity, and degradation of WNF-doped CPC (wnf-CPC) were investigated. Scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, and inductively coupled plasma atomic emission spectroscopy were utilized. Additionally, methyl-thiazolyl-tetrazolium bromide assay, scanning electron microscopy, inductively coupled plasma atomic emission spectroscopy, and histological evaluation were used to study the cell and tissue responses to wnf-CPC, both in vitro and in vivo. The results confirmed that the addition of WNFs into CPC had no obvious effect on the setting time or the compressive strength of wnf-CPC, provided the WNF amount was not more than 10 wt%. However, the hydrophilicity and degradability of wnf-CPC were significantly improved by the addition of WNFs -this was because of the change of microstructure caused by the WNFs. The preferred dissolution of WNFs caused the formation of microporosity in wnf-CPC when soaked in tris hydrochloride solution. The microporosity enlarged the surface area of the wnf-CPC and so promoted degradation of the wnf-CPC when in contact with liquid. In addition, MG-63 cell attachment and proliferation on the wnf-CPC were superior to that on the CPC, indicating that incorporation of WNFs into CPC improved the biological properties for wnf-CPC. Following the implantation of wnf-CPC into bone defects of rabbits, histological evaluation showed that wnf-CPC enhanced the efficiency of new bone formation in comparison with CPC, indicating excellent biocompatibility and osteogenesis of wnf-CPC. In conclusion, wnf-CPC exhibited promising prospects in bone regeneration.

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Rheological properties of concentrated aqueous injectable calcium phosphate cement slurry

Cited by 111 publications

References 35 publications

Antimicrobial activity of bone cements embedded with organic nanoparticles

Antimicrobial activity of bone cements embedded with organic nanoparticles

Effect of selected non-ionic surfactants on the flow behavior of aqueous veegum suspensions

Wollastonite nanofiber–doped self-setting calcium phosphate bioactive cement for bone tissue regeneration

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Rheological properties of concentrated aqueous injectable calcium phosphate cement slurry

Cited by 111 publications

References 35 publications

Antimicrobial activity of bone cements embedded with organic nanoparticles

Antimicrobial activity of bone cements embedded with organic nanoparticles

Effect of selected non-ionic surfactants on the flow behavior of aqueous veegum suspensions

Wollastonite nanofiber&ndash;doped self-setting calcium phosphate bioactive cement for bone tissue regeneration

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Product

Resources

About

Wollastonite nanofiber–doped self-setting calcium phosphate bioactive cement for bone tissue regeneration