Rheological properties of synovial fluid due to viscosupplements: A review for osteoarthritis remedy

More, S.; Kotiya, Akhilesh A.; Kotia, Ankit; Ghosh, S.K.; Spyrou, Leonidas A.; Sarris, Ioannis E.

doi:10.1016/j.cmpb.2020.105644

Cited by 39 publications

(23 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Plasma is richer in bridging molecules, particularly fibrinogen, fibronectin, and albumin [ 21 ], but has lower viscosity. BSF is more viscous, particularly due to the abundance of hyaluronic acid (HA) [ 23 ], absent in plasma. Implementing these observations in our mathematical model, we were able to reproduce all the qualitative differences observed in planktonic aggregation and sessile biofilm formation in the three different media.…”

Section: Discussionmentioning

confidence: 99%

Host Environment Shapes S. aureus Social Behavior as Revealed by Microscopy Pattern Formation and Dynamic Aggregation Analysis

et al. 2022

View full text Add to dashboard Cite

Understanding how bacteria adapt their social behavior to environmental changes is of crucial importance from both biological and clinical perspectives. Staphylococcus aureus is among the most common infecting agents in orthopedics, but its recalcitrance to the immune system and to antimicrobial treatments in the physiological microenvironment are still poorly understood. By means of optical and confocal microscopy, image pattern analysis, and mathematical modeling, we show that planktonic biofilm-like aggregates and sessile biofilm lifestyles are two co-existing and interacting phases of the same environmentally adaptive developmental process and that they exhibit substantial differences when S. aureus is grown in physiological fluids instead of common lab media. Physicochemical properties of the physiological microenvironment are proposed to be the key determinants of these differences. Besides providing a new tool for biofilm phenotypic analysis, our results suggest new insights into the social behavior of S. aureus in physiological conditions and highlight the inadequacy of commonly used lab media for both biological and clinical studies of bacterial development.

show abstract

Section: Discussionmentioning

confidence: 99%

Host Environment Shapes S. aureus Social Behavior as Revealed by Microscopy Pattern Formation and Dynamic Aggregation Analysis

et al. 2022

View full text Add to dashboard Cite

show abstract

“…It is likely that the lamina splendens consists of precisely these macromolecules, precipitated onto the cartilage surface and compacted by the functional load; lubricin at least is reported to bind avidly to the underlying collagen fibrils (Majd et al, 2014; Chang, Guilak, Jay & Zauscher, 2014). The extraordinary low coefficient of friction of the cartilage surface has been attributed to a synergistic interaction of hyaluronic acid either with lubricin (Ye et al, 2019; More et al, 2020), or with phospholipids (Lin et al, 2019), or both (Majd et al, 2014; Seror, Zhu, Goldberg, Day & Klein, 2015). Lubricin can readily self‐assemble into dense, stable polymer brushes (Greene et al, 2015), a description consistent with the bodies shown in our Figure 4.…”

Section: Discussionmentioning

confidence: 99%

“…Lubricin can readily self‐assemble into dense, stable polymer brushes (Greene et al, 2015), a description consistent with the bodies shown in our Figure 4. Lubricin supplementation has been attempted as a chondroprotective measure in animal models of osteoarthritis, always with measurably beneficial effects (Watkins & Reesink, 2020), while intra‐articular application of hyaluronic acid is widely used to relieve arthropathies in the clinical practice, where its effectiveness is incontestable and lasts for several months (More et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Slippery when wet: The free surface of the articular cartilage

Raspanti

Protasoni

Zecca

et al. 2020

Microscopy Res & Technique

View full text Add to dashboard Cite

The free surface of the articular cartilage must withstand compressive and shearing forces, maintain a low friction coefficient and allow oxygen and metabolites to reach the underlying matrix. In many ways it is critical to the physiology of the whole tissue and its disruption always involves deep pathological alterations and loss of the joint integrity. Being very difficult to image with section-based conventional techniques, it was often described by previous research in conflicting terms or entirely overlooked.

show abstract

“…This behavior of synovial fluid is attributed to its viscoelastic-shear thinning fluid, which is mainly due to the presence of hyaluronic acid (HA), lubricin, serum albumin, and globulin [3]. The interaction between these molecules results in synovial fluid's boundary layer formation during less shear and elasto-hydrodynamic behavior during high shear [4]. The presence of synovial fluid between cartilages and bones ensures smooth operation of the joint.…”

Section: Introductionmentioning

confidence: 99%

“…Osteoarthritis is quite a common problem in older age, especially in the hip joint and the knee joints due to heavy loading [4]. In this disease, there is significant alteration of the properties and concentration of synovial fluid.…”

Section: Introductionmentioning

confidence: 99%

Rheological Properties and Its Effect on the Lubrication Mechanism of PVP K30 and PVP 40-50 G as Artificial Synovial Fluids

Kotia

Yadav

et al. 2021

Inventions

View full text Add to dashboard Cite

The effect of polyvinylpyrrolidone (PVP) on the rheological properties of joint prostheses is still unclear, despite its good lubricity and biocompatibility. In the present work, PVP K30 and PVP 40-50 G solutions at different concentrations were analyzed for rheological and lubrication properties. The rheological properties of the samples were measured at a shear rate range of 0–1800 s−1 (advanced air bearing rheometer Bohlin Gemini 2 and Plate MCR 72/92 rheometer for PVP30 and PVP 40-50 G, respectively). It was found that both the viscosity and shear stress of the samples reduced with a shear rate increase. PVP 40-50 G/sterile water showed higher viscosity as compared to the PVP K30/sterile water sample at a lower shear rate. However, at a higher shear rate, the PVP K30 sample produced better results. Further numerical study results showed the pressure and molecular viscosity distributions. The inclusion of PVP improved the load caring capacity and hence, it is a promising lubrication additive for artificial joints.

show abstract

Rheological properties of synovial fluid due to viscosupplements: A review for osteoarthritis remedy

Cited by 39 publications

References 61 publications

Host Environment Shapes S. aureus Social Behavior as Revealed by Microscopy Pattern Formation and Dynamic Aggregation Analysis

Host Environment Shapes S. aureus Social Behavior as Revealed by Microscopy Pattern Formation and Dynamic Aggregation Analysis

Slippery when wet: The free surface of the articular cartilage

Rheological Properties and Its Effect on the Lubrication Mechanism of PVP K30 and PVP 40-50 G as Artificial Synovial Fluids

Contact Info

Product

Resources

About